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Review: could Herceptin cause Peripheral sensory neuropathy?

We study 10,352 people who have side effects while taking Herceptin from FDA and social media. Among them, 15 have Peripheral sensory neuropathy. Find out below who they are, when they have Peripheral sensory neuropathy and more.

Get connected: join a mobile support group for people who take Herceptin and have Peripheral sensory neuropathy >>>

Herceptin

Herceptin (latest outcomes from 10,447 users) has active ingredients of trastuzumab. It is often used in breast cancer.

Peripheral sensory neuropathy

Peripheral sensory neuropathy (damage to one or more of your peripheral nerves) (latest reports from 11,023 patients) has been reported by people with multiple myeloma, breast cancer, rheumatoid arthritis, high blood pressure, osteoporosis.

On Oct, 13, 2014: 10,350 people reported to have side effects when taking Herceptin. Among them, 15 people (0.14%) have Peripheral Sensory Neuropathy.

Trend of Peripheral sensory neuropathy in Herceptin reports

Time on Herceptin when people have Peripheral sensory neuropathy * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Peripheral sensory neuropathy75.00%12.50%0.00%12.50%0.00%0.00%0.00%

Gender of people who have Peripheral sensory neuropathy when taking Herceptin * :

FemaleMale
Peripheral sensory neuropathy87.50%12.50%

Age of people who have Peripheral sensory neuropathy when taking Herceptin * :

0-12-910-1920-2930-3940-4950-5960+
Peripheral sensory neuropathy0.00%0.00%0.00%0.00%21.05%21.05%36.84%21.05%

Severity of Peripheral sensory neuropathy when taking Herceptin ** :

n/a

How people recovered from Peripheral sensory neuropathy ** :

n/a

Top conditions involved for these people * :

  1. Breast cancer (11 people, 73.33%)
  2. Breast cancer metastatic (5 people, 33.33%)
  3. Gastric cancer (2 people, 13.33%)
  4. Neoplasm malignant (1 people, 6.67%)

Top co-used drugs for these people * :

  1. Paclitaxel (12 people, 80.00%)
  2. Cyclophosphamide (7 people, 46.67%)
  3. Doxorubicin hcl (6 people, 40.00%)
  4. Tamoxifen citrate (4 people, 26.67%)
  5. Leucovorin calcium (3 people, 20.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Citations of the study:
- http://www.kup.at/kup/pdf/10376.pdf

Do you have Peripheral Sensory Neuropathy while taking Herceptin?

Get connected! Join a mobile support group:
- support group for people who take Herceptin and have Peripheral Sensory Neuropathy
- support group for people who take Herceptin
- support group for people who have Peripheral Sensory Neuropathy

Comments from related studies:

  • From this study (3 weeks ago):

  • Still getting Herceptin after 7 months. Will be finished in March 2015. Began taking the Anastrozole in June of 2014 and will be taking this medication for five years. Two weeks ago started waking up in the middle of the night with numbness and tingling sensation in hands and fingers. It is uncomfortable and disturbing sleep. I began wearing gloves to bed which is helping somewhat.

    Reply

  • From this study (1 month ago):

  • Also take a liver tonic, kidney tonic, dandelion, Vitamin B, Calcium tablet, vitamin E, vitamin, multivitamin, fish oil, curcumin and selenium. Drink green tea and dandelion tea and liver detox tea.

    Reply

  • From this study (1 month ago):

  • I've been on Herceptin 10 months. About 2 months ago, I started having sudden bouts of intense itchy skin that I cannot tolerate. It affects different places on my body; arms, chest, neck, back, legs, just about anywhere, and usually more than one place at same time. I generally wipe with a cool washcloth, and lotion up. That helps reduce the intensity of itching, but it's not complete relief.

    Now, for 2 days, I've had a painful rash on my ribs, below the left breast. It is NOT in a fold where an infection could occur. If it matters, the rash is on the same side as the breast cancer.

    I called the cancer center, where a nurse said it was likely shingles. I have been a medical professional in the past, and this does not look like shingles. There is no weeping, no vesicles, it is completely smooth. I take benadryl 50mg 3x daily, and Acyclovir 400mg x2 daily (prophylactically). I'd be surprised if it turns out to be shingles.

    Nothing has explained the itching bouts that I have everywhere else. I've read that Herceptin can cause itching in a small percentage of people. The nurse said that this only occurs as a possible reaction at the beginning of treatment, which is not my case. What do think about the itching? What about the rash?

    Reply

    Kelly on Sep, 11, 2014:

    Hi- I was diagnosed with breast cancer 1 year ago. Had a mastectomy, and chemo (Adriamycin & Cytoxan) then Taxol &Herceptin. Chemo lasted 5months, and I have been on Herceptin for 10 months total so far. I began having sudden almost painful itching on my arms, neck, chest and back anytime I get hot. This started after the chemo stopped, but while still on Herceptin . I asked my oncologist about it, and all he could come up with was to try a good lotion (Aquaphor). I don't use it everyday, but I probably should, to see if it makes a difference. I still get the itching, but not quite as often now. It's an awful feeling, almost like pins sticking me. Hopefully after all of this gets out of my system in a few more months things will get back to normal.

    Reply

    carpa on Sep, 3, 2014:

    I just turned 50 have been on Herceptin for one year (part of TCH-which ended 1/14) my last three infusions of Herceptin only I have had skin rash that is itchy-they keep telling me it is contact dermatitis but I am not convinced. They are a lot of tiny dots-like you took a pin and made little holes in something-they are red-not very raised and itchy. The last rash I had turned into welts and was extremely itchy-traveled along my radiation fields up to my face-I had it on my eyelids and nose before they would give me steroids-I hope this rash does not progress to that stage. I keep being told that Herceptin does not produce a rash this late into the treatment time.

    Reply

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