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Review: could Humira cause Guillain-barre syndrome?





Summary: Guillain-barre syndrome is found among people who take Humira, especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months, also take medication Methotrexate, and have Rheumatoid arthritis.

We study 135,973 people who have side effects while taking Humira from FDA and social media. Among them, 100 have Guillain-barre syndrome. Find out below who they are, when they have Guillain-barre syndrome and more.

You are not alone: join a mobile support group for people who take Humira and have Guillain-barre syndrome >>>

Humira

Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. (latest outcomes from Humira 136,693 users)

Guillain-barre syndrome

On Dec, 13, 2014: 135,973 people reported to have side effects when taking Humira. Among them, 100 people (0.07%) have Guillain-barre Syndrome.

Trend of Guillain-barre syndrome in Humira reports

Time on Humira when people have Guillain-barre syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Guillain-barre syndrome24.14%37.93%13.79%8.62%15.52%0.00%0.00%

Gender of people who have Guillain-barre syndrome when taking Humira * :

FemaleMale
Guillain-barre syndrome56.44%43.56%

Age of people who have Guillain-barre syndrome when taking Humira * :

0-12-910-1920-2930-3940-4950-5960+
Guillain-barre syndrome0.00%0.00%1.28%5.13%12.82%20.51%46.15%14.10%

Severity of Guillain-barre syndrome when taking Humira ** :

n/a

How people recovered from Guillain-barre syndrome ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (52 people, 52.00%)
  2. Psoriasis (22 people, 22.00%)
  3. Crohn's disease (13 people, 13.00%)
  4. Hypertension (9 people, 9.00%)
  5. Pain (6 people, 6.00%)

Top co-used drugs for these people * :

  1. Methotrexate (22 people, 22.00%)
  2. Prednisone (9 people, 9.00%)
  3. Leflunomide (7 people, 7.00%)
  4. Aspirin (7 people, 7.00%)
  5. Prednisone tab (7 people, 7.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Guillain-barre Syndrome while taking Humira?

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- support group for people who take Humira and have Guillain-barre Syndrome
- support group for people who take Humira

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More questions for: Humira, Guillain-barre syndrome

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    My friend said she didn't feel good but was still active until about 20 hours before her death in the ICU on a ventilator from sepsis. She was just 55. This is a horror story. People are devastated.
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  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
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  • Transient global amnesia
    Having been on Humira for 12 months with full clearing of all symptoms of severe plaque psoriasis, I am a little unnerved by this episode. I was out clearing a substantial amount of snow from one of our decks. I remember being at the half way mark, and the next thing I remember is being on the way to emerge with my husband. Apparently we were in for lunch, and I lost focus when I went to the kitchen to make apot of tea. I commented on something I had taken out for dinner, but thought he had done so. He started to question me About the previous two days in which we had had a house full of company, and I didn't recall any of it. I now recall all of the weekend, but have no recollection of about a two and a half hour period prior to the arrival at emerg. Now, one day later, that memory is still non existent.
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