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Review: could Hydrochlorothiazide cause Diabetes mellitus?

Summary: Diabetes mellitus could be caused by Hydrochlorothiazide, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take Seroquel, and have Depression.

We study 59,875 people who have side effects while taking Hydrochlorothiazide from FDA and social media. Among them, 983 have Diabetes mellitus. Find out below who they are, when they have Diabetes mellitus and more.

On Apr, 10, 2014: 59,875 people reported to have side effects when taking Hydrochlorothiazide. Among them, 1,107 people (1.85%) have Diabetes Mellitus. They amount to 0.29% of all the 381,551 people who have Diabetes Mellitus on eHealthMe.

Trend of Diabetes mellitus in Hydrochlorothiazide reports

Time on Hydrochlorothiazide when people have Diabetes mellitus * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Diabetes mellitus14.29%28.57%0.00%0.00%28.57%21.43%7.14%

Gender of people who have Diabetes mellitus when taking Hydrochlorothiazide * :

FemaleMale
Diabetes mellitus63.60%36.40%

Age of people who have Diabetes mellitus when taking Hydrochlorothiazide * :

0-12-910-1920-2930-3940-4950-5960+
Diabetes mellitus0.00%0.00%0.00%2.71%9.08%29.23%27.35%31.63%

Severity of Diabetes mellitus when taking Hydrochlorothiazide ** :

leastmoderateseveremost severe
Diabetes mellitus0.00%66.67%33.33%0.00%

How people recovered from Diabetes mellitus ** :

while on the drugafter off the drugnot yet
Diabetes mellitus0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (256 people, 23.13%)
  2. Hypertension (221 people, 19.96%)
  3. Anxiety (124 people, 11.20%)
  4. Bipolar disorder (117 people, 10.57%)
  5. Pain (104 people, 9.39%)

Top co-used drugs for these people * :

  1. Seroquel (385 people, 34.78%)
  2. Aspirin (272 people, 24.57%)
  3. Lipitor (216 people, 19.51%)
  4. Lisinopril (212 people, 19.15%)
  5. Zyprexa (203 people, 18.34%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Hydrochlorothiazide, Diabetes mellitus

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On eHealthMe, Hydrochlorothiazide (hydrochlorothiazide) is often used for high blood pressure. Find out below the conditions Hydrochlorothiazide is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Hydrochlorothiazide used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (13 months ago):

  • I started on chlorthalidone is 2011 after realizing HCTZ had caused me to become diabetic and in general not very effective in lowering my BP. I initially had started out with Hyzaar 100-25. So I went on Cozaar(generic) 100 mg and chlorthalidone 25 mg. After having a year of K+ <3.1,decided to abruptly stop chlorthalidone. Didn't think would rebound,as this is a diuretic. Rebounding started day 4-5. I am going to see if by day 10 the rebound effect stops. If it doesn't I will restart 12.5 and then wean of after a week. I am type 2 DM and my fasting blood sugars have dropped 30 mg/dl. Cozaar is totally ineffective. I also have had terrible knee pain since being Losartin, HCTZ/or chlorthalidone.

    Reply

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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