Review: could Hydroxyurea cause Fatigue?


Fatigue is found among people who take Hydroxyurea, especially for people who are male, 60+ old , have been taking the drug for 1 - 6 months, also take medication Folic Acid, and have Chronic myeloid leukaemia . We study 3,659 people who have side effects while taking Hydroxyurea from FDA and social media. Among them, 224 have Fatigue. Find out below who they are, when they have Fatigue and more.

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Hydroxyurea has active ingredients of hydroxyurea. It is often used in essential thrombocythaemia. (latest outcomes from Hydroxyurea 3,660 users)


Fatigue (feeling of tiredness) has been reported by people with breathing difficulty, pain, weakness, insomnia, stress and anxiety (latest reports from 231,716 Fatigue patients).

On Aug, 22, 2016

3,659 people reported to have side effects when taking Hydroxyurea.
Among them, 224 people (6.12%) have Fatigue

Number of reports submitted per year:

Could Hydroxyurea cause Fatigue?

Time on Hydroxyurea when people have Fatigue *:

  • < 1 month: 18.75 %
  • 1 - 6 months: 45.83 %
  • 6 - 12 months: 8.33 %
  • 1 - 2 years: 2.08 %
  • 2 - 5 years: 16.67 %
  • 5 - 10 years: 6.25 %
  • 10+ years: 2.08 %

Gender of people who have Fatigue when taking Hydroxyurea *:

  • female: 47.89 %
  • male: 52.11 %

Age of people who have Fatigue when taking Hydroxyurea *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 1.1 %
  • 20-29: 2.21 %
  • 30-39: 8.84 %
  • 40-49: 16.02 %
  • 50-59: 12.71 %
  • 60+: 59.12 %

Severity if Fatigue when taking Hydroxyurea **:

  • least: 0.0 %
  • moderate: 60 %
  • severe: 20 %
  • most severe: 20 %

Top conditions involved for these people *:

  • Hypertension (38 people)
  • Chronic Myeloid Leukaemia (38 people)
  • Pain (22 people)
  • Depression (19 people)
  • Pain Management (16 people)

Top co-used drugs for these people *:

  • Folic Acid (41 people)
  • Acetaminophen (31 people)
  • Norvasc (27 people)
  • Protonix (26 people)
  • Lisinopril (26 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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