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Review: could Isoniazid cause Hepatotoxicity?

We study 7,411 people who have side effects while taking Isoniazid from FDA and social media. Among them, 120 have Hepatotoxicity. Find out below who they are, when they have Hepatotoxicity and more.

Get connected: join a mobile support group for people who take Isoniazid and have Hepatotoxicity >>>


Isoniazid (latest outcomes from 7,570 users) has active ingredients of isoniazid. It is often used in tuberculosis.


Hepatotoxicity (chemical-driven liver damage) (latest reports from 33,199 patients) has been reported by people with hiv infection, pain, depression, high blood pressure, rheumatoid arthritis.

On Oct, 25, 2014: 7,411 people reported to have side effects when taking Isoniazid. Among them, 120 people (1.62%) have Hepatotoxicity.

Trend of Hepatotoxicity in Isoniazid reports

Time on Isoniazid when people have Hepatotoxicity * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Hepatotoxicity when taking Isoniazid * :


Age of people who have Hepatotoxicity when taking Isoniazid * :


Severity of Hepatotoxicity when taking Isoniazid ** :


How people recovered from Hepatotoxicity ** :


Top conditions involved for these people * :

  1. Tuberculosis (43 people, 35.83%)
  2. Hiv infection (31 people, 25.83%)
  3. Prophylaxis (15 people, 12.50%)
  4. Pulmonary tuberculosis (10 people, 8.33%)
  5. Renal transplant (6 people, 5.00%)

Top co-used drugs for these people * :

  1. Rifampicin (56 people, 46.67%)
  2. Pyrazinamide (55 people, 45.83%)
  3. Ethambutol hydrochloride (33 people, 27.50%)
  4. Rifampin (24 people, 20.00%)
  5. Cotrim (16 people, 13.33%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Hepatotoxicity while taking Isoniazid?

Get connected! Join a mobile support group:
- support group for people who take Isoniazid and have Hepatotoxicity
- support group for people who take Isoniazid
- support group for people who have Hepatotoxicity

Comments from related studies:

  • From this study (5 months ago):

  • Got ulcerative colitis after taking isoniazid


  • From this study (6 months ago):

  • I have been taking Isoniazid for 6 months now and I have 3 more months to go. After a month 1 1/2 of taking this medication I began to have alot of palpitations and then to PVCs. I have been diagnosed with Paroxysmal A-Fib since 2000 but it is Sinus. I recently stopped the Flecainide because I thought that was causing me to have this problem. But I have been taking Flecainide since 2003.

    I don't have Tuberculosis. I will always be positive with TB test because of BCG Vaccine that they did in Asia.


  • From this study (8 months ago):

  • I have only been on the drugs for 9 days.
    Have noticed the symptoms have increased in frequency since the beginning.
    While I know you are supposed to avoid alcohol, I had a cocktail and a glass of wine with dinner last night and felt intoxicated (i.e., clumsiness in walking, very tired). Those symptoms wore off and I am fine today.


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More reviews for: Isoniazid, Hepatotoxicity

On eHealthMe, Isoniazid (isoniazid) is often used for tuberculosis. Find out below the conditions Isoniazid is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Isoniazid used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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