Review: could Isoniazid cause Hepatotoxicity?


Summary

Hepatotoxicity is found among people who take Isoniazid, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Pyrazinamide, and have Tuberculosis . We study 8,284 people who have side effects while taking Isoniazid from FDA and social media. Among them, 128 have Hepatotoxicity. Find out below who they are, when they have Hepatotoxicity and more.

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Isoniazid

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. (latest outcomes from Isoniazid 10,069 users)

Hepatotoxicity

Hepatotoxicity (chemical-driven liver damage) has been reported by people with breathing difficulty, fever, posterior reversible encephalopathy syndrome, c-reactive protein increased, febrile neutropenia (latest reports from 7,951 Hepatotoxicity patients).

On Sep, 30, 2016

8,284 people reported to have side effects when taking Isoniazid.
Among them, 128 people (1.55%) have Hepatotoxicity


Number of reports submitted per year:

Could Isoniazid cause Hepatotoxicity?

Time on Isoniazid when people have Hepatotoxicity *:

  • < 1 month: 11.76 %
  • 1 - 6 months: 79.41 %
  • 6 - 12 months: 5.88 %
  • 1 - 2 years: 2.94 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hepatotoxicity when taking Isoniazid *:

  • female: 66.13 %
  • male: 33.87 %

Age of people who have Hepatotoxicity when taking Isoniazid *:

  • 0-1: 6.09 %
  • 2-9: 6.96 %
  • 10-19: 5.22 %
  • 20-29: 11.3 %
  • 30-39: 18.26 %
  • 40-49: 11.3 %
  • 50-59: 17.39 %
  • 60+: 23.48 %

Top conditions involved for these people *:

  • Tuberculosis (56 people, 43.75%)
  • Hiv Infection (33 people, 25.78%)
  • Prophylaxis (15 people, 11.72%)
  • Pulmonary Tuberculosis (11 people, 8.59%)
  • Renal Transplant (6 people, 4.69%)

Top co-used drugs for these people *:

  • Pyrazinamide (60 people, 46.88%)
  • Rifampicin (57 people, 44.53%)
  • Ethambutol Hydrochloride (32 people, 25.00%)
  • Rifampin (25 people, 19.53%)
  • Lamivudine (17 people, 13.28%)

Top other side effects for these people *:

  • Vomiting (16 people, 12.50%)
  • Jaundice (16 people, 12.50%)
  • Aspartate Aminotransferase Increased (16 people, 12.50%)
  • Alanine Aminotransferase Increased (16 people, 12.50%)
  • Blood Bilirubin Increased (15 people, 11.72%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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