Could Isoniazid cause Hepatotoxicity - from FDA reports


Summary

Hepatotoxicity is found among people who take Isoniazid, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Pyrazinamide, and have Tuberculosis . We study 8,285 people who have side effects while taking Isoniazid from FDA. Among them, 128 have Hepatotoxicity. Find out below who they are, when they have Hepatotoxicity and more.

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Isoniazid

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. (latest outcomes from Isoniazid 10,293 users)

Hepatotoxicity

Hepatotoxicity (chemical-driven liver damage) has been reported by people with hiv infection, pain, high blood pressure, preventive health care, rheumatoid arthritis (latest reports from 8,173 Hepatotoxicity patients).

On Nov, 30, 2016

8,285 people reported to have side effects when taking Isoniazid.
Among them, 128 people (1.54%) have Hepatotoxicity


Number of reports submitted per year:

Could Isoniazid cause Hepatotoxicity?

Time on Isoniazid when people have Hepatotoxicity *:

  • < 1 month: 11.76 %
  • 1 - 6 months: 79.41 %
  • 6 - 12 months: 5.88 %
  • 1 - 2 years: 2.94 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hepatotoxicity when taking Isoniazid *:

  • female: 66.13 %
  • male: 33.87 %

Age of people who have Hepatotoxicity when taking Isoniazid *:

  • 0-1: 6.09 %
  • 2-9: 6.96 %
  • 10-19: 5.22 %
  • 20-29: 11.3 %
  • 30-39: 18.26 %
  • 40-49: 11.3 %
  • 50-59: 17.39 %
  • 60+: 23.48 %

Top conditions involved for these people *:

  • Tuberculosis (56 people, 43.75%)
  • Hiv Infection (33 people, 25.78%)
  • Preventive Health Care (15 people, 11.72%)
  • Pulmonary Tuberculosis (12 people, 9.38%)
  • Kidney Transplant (6 people, 4.69%)

Top co-used drugs for these people *:

  • Pyrazinamide (60 people, 46.88%)
  • Ethambutol Hydrochloride (32 people, 25.00%)
  • Rifampin (25 people, 19.53%)
  • Lamivudine (17 people, 13.28%)
  • Cotrim (16 people, 12.50%)

Top other side effects for these people *:

  • Nausea And Vomiting (16 people, 12.50%)
  • Jaundice - Yellow Skin (16 people, 12.50%)
  • Aspartate Aminotransferase Increased (16 people, 12.50%)
  • Alanine Aminotransferase Increased (16 people, 12.50%)
  • Blood Bilirubin Increased (15 people, 11.72%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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