Could Isoniazid cause Hepatotoxicity - from FDA reports


Summary

Hepatotoxicity is found among people who take Isoniazid, especially for people who are male, 60+ old , have been taking the drug for 1 - 6 months, also take medication Pyrazinamide, and have Tuberculosis . We study 9,998 people who have side effects while taking Isoniazid from FDA. Among them, 221 have Hepatotoxicity. Find out below who they are, when they have Hepatotoxicity and more.

What to expect?

If you take Isoniazid and have Hepatotoxicity, find out what symptoms you could have in 1 year or longer.

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Isoniazid

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. (latest outcomes from Isoniazid 10,295 users)

Hepatotoxicity

Hepatotoxicity (chemical-driven liver damage) has been reported by people with hiv infection, pain, high blood pressure, preventive health care, rheumatoid arthritis (latest reports from 8,173 Hepatotoxicity patients).

On Dec, 31, 2016

9,998 people reported to have side effects when taking Isoniazid.
Among them, 221 people (2.21%) have Hepatotoxicity


Number of reports submitted per year:

Could Isoniazid cause Hepatotoxicity?

Time on Isoniazid when people have Hepatotoxicity *:

  • < 1 month: 15.79 %
  • 1 - 6 months: 76.32 %
  • 6 - 12 months: 5.26 %
  • 1 - 2 years: 2.63 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hepatotoxicity when taking Isoniazid *:

  • female: 49.52 %
  • male: 50.48 %

Age of people who have Hepatotoxicity when taking Isoniazid *:

  • 0-1: 3.52 %
  • 2-9: 4.52 %
  • 10-19: 4.52 %
  • 20-29: 10.55 %
  • 30-39: 15.08 %
  • 40-49: 11.06 %
  • 50-59: 18.59 %
  • 60+: 32.16 %

Top conditions involved for these people *:

  • Tuberculosis (116 people, 52.49%)
  • Hiv Infection (35 people, 15.84%)
  • Pulmonary Tuberculosis (18 people, 8.14%)
  • Preventive Health Care (15 people, 6.79%)
  • Latent Tuberculosis (8 people, 3.62%)

Top co-used drugs for these people *:

  • Pyrazinamide (59 people, 26.70%)
  • Ethambutol Hydrochloride (31 people, 14.03%)
  • Rifampin (24 people, 10.86%)
  • Lamivudine (17 people, 7.69%)
  • Cotrim (16 people, 7.24%)

Top other side effects for these people *:

  • Jaundice - Yellow Skin (63 people, 28.51%)
  • Hepatic Failure (54 people, 24.43%)
  • Liver Function Test Abnormal (49 people, 22.17%)
  • Nausea And Vomiting (19 people, 8.60%)
  • Acute Hepatic Failure (17 people, 7.69%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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