Review: could Isoniazid cause Hepatotoxicity?


Summary

Hepatotoxicity is found among people who take Isoniazid, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Pyrazinamide, and have Tuberculosis . We study 8,107 people who have side effects while taking Isoniazid from FDA and social media. Among them, 126 have Hepatotoxicity. Find out below who they are, when they have Hepatotoxicity and more.

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Isoniazid

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. (latest outcomes from Isoniazid 8,394 users)

Hepatotoxicity

Hepatotoxicity (chemical-driven liver damage) has been reported by people with red blood cell sedimentation rate increased, fever, jaundice cholestatic, acute kidney failure, febrile neutropenia (latest reports from 6,319 Hepatotoxicity patients).

On Aug, 29, 2016

8,107 people reported to have side effects when taking Isoniazid.
Among them, 126 people (1.55%) have Hepatotoxicity


Number of reports submitted per year:

Could Isoniazid cause Hepatotoxicity?

Time on Isoniazid when people have Hepatotoxicity *:

  • < 1 month: 12.12 %
  • 1 - 6 months: 78.79 %
  • 6 - 12 months: 6.06 %
  • 1 - 2 years: 3.03 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hepatotoxicity when taking Isoniazid *:

  • female: 65.57 %
  • male: 34.43 %

Age of people who have Hepatotoxicity when taking Isoniazid *:

  • 0-1: 6.14 %
  • 2-9: 7.02 %
  • 10-19: 4.39 %
  • 20-29: 11.4 %
  • 30-39: 18.42 %
  • 40-49: 11.4 %
  • 50-59: 17.54 %
  • 60+: 23.68 %

Top conditions involved for these people *:

  • Tuberculosis (56 people)
  • Hiv Infection (33 people)
  • Prophylaxis (15 people)
  • Pulmonary Tuberculosis (10 people)
  • Renal Transplant (6 people)

Top co-used drugs for these people *:

  • Pyrazinamide (59 people)
  • Rifampicin (56 people)
  • Ethambutol Hydrochloride (32 people)
  • Rifampin (25 people)
  • Lamivudine (17 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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