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Review: could Isoniazid cause Mental disorder?

Summary: Mental disorder could be caused by Isoniazid, especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months, also take Pyrazinamide, and have Hiv infection.

We study 7,369 people who have side effects while taking Isoniazid from FDA and social media. Among them, 24 have Mental disorder. Find out below who they are, when they have Mental disorder and more.

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On Apr, 10, 2014: 7,369 people reported to have side effects when taking Isoniazid. Among them, 24 people (0.33%) have Mental Disorder. They amount to 0.02% of all the 103,432 people who have Mental Disorder on eHealthMe.

Trend of Mental disorder in Isoniazid reports

Time on Isoniazid when people have Mental disorder * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Mental disorder14.29%57.14%0.00%0.00%28.57%0.00%0.00%

Gender of people who have Mental disorder when taking Isoniazid * :

FemaleMale
Mental disorder73.91%26.09%

Age of people who have Mental disorder when taking Isoniazid * :

0-12-910-1920-2930-3940-4950-5960+
Mental disorder0.00%9.52%0.00%0.00%57.14%14.29%19.05%0.00%

Severity of Mental disorder when taking Isoniazid ** :

n/a

How people recovered from Mental disorder ** :

n/a

Top conditions involved for these people * :

  1. Hiv infection (16 people, 66.67%)
  2. Pulmonary tuberculosis (4 people, 16.67%)
  3. Tuberculosis (4 people, 16.67%)
  4. Prophylaxis (4 people, 16.67%)
  5. Hypertension (2 people, 8.33%)

Top co-used drugs for these people * :

  1. Pyrazinamide (17 people, 70.83%)
  2. Rifampicin (15 people, 62.50%)
  3. Lamivudine (11 people, 45.83%)
  4. Zidovudine (10 people, 41.67%)
  5. Nevirapine (9 people, 37.50%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Isoniazid, Mental disorder

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On eHealthMe, Isoniazid (isoniazid) is often used for tuberculosis. Find out below the conditions Isoniazid is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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Other drugs that are used to treat the same conditions:

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Could your condition cause it?

Comments from related studies:

  • From this study (3 weeks ago):

  • I have taken metformin on and off for several years but never for long periods of time, recently I took it for 3 months consistently, i HEARD REPORTS THAT SOME PEOPLE WERE HAVING TROUBLE WITH THEIR MEMORY AFTER TAKING METFORMIN. i HAVE ADHD SO MY MEMORY IS POOR TO BEGIN WITH. BUT RECENTLY i NOTICED A STEEP DECLINE AFTER HEARING THAT METFORMIN COULD CAUSE THIS PROBLEM. COULD IT JUST BE THE POWER OF SUGGESTION?

    Reply

  • From this study (4 weeks ago):

  • I have only been on the drugs for 9 days.
    Have noticed the symptoms have increased in frequency since the beginning.
    While I know you are supposed to avoid alcohol, I had a cocktail and a glass of wine with dinner last night and felt intoxicated (i.e., clumsiness in walking, very tired). Those symptoms wore off and I am fine today.

    Reply

  • From this study (2 months ago):

  • Misdiagnosed as TB and treated with isoniazid for a month. Now stopped isoniazid. Radiologist diagnosed problem as early small airway obstruction. Now there is feet swelling (it was there before also) and eyes are getting red very often.

    Reply

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