Review: could Letrozole cause Osteoporosis?


Osteoporosis is found among people who take Letrozole, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Zometa, and have Breast cancer . We study 2,329 people who have side effects while taking Letrozole from FDA and social media. Among them, 48 have Osteoporosis. Find out below who they are, when they have Osteoporosis and more.

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Letrozole has active ingredients of letrozole. It is often used in breast cancer. (latest outcomes from Letrozole 2,525 users)


Osteoporosis (bones weak and more likely to break) has been reported by people with pain, weakness, back pain, joint pain, pain in extremity (latest reports from 121,438 Osteoporosis patients).

On Aug, 28, 2016

2,329 people reported to have side effects when taking Letrozole.
Among them, 48 people (2.06%) have Osteoporosis

Number of reports submitted per year:

Could Letrozole cause Osteoporosis?

Time on Letrozole when people have Osteoporosis *:

  • < 1 month: 20 %
  • 1 - 6 months: 20 %
  • 6 - 12 months: 20 %
  • 1 - 2 years: 20 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 20 %
  • 10+ years: 0.0 %

Gender of people who have Osteoporosis when taking Letrozole *:

  • female: 97.92 %
  • male: 2.08 %

Age of people who have Osteoporosis when taking Letrozole *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 18.18 %
  • 50-59: 39.39 %
  • 60+: 42.42 %

Severity if Osteoporosis when taking Letrozole **:

  • least: 50 %
  • moderate: 50 %
  • severe: 0.0 %
  • most severe: 0.0 %

Top conditions involved for these people *:

  • Breast Cancer (32 people)
  • Anaemia (12 people)
  • Breast Cancer Female (3 people)
  • Osteoporosis (2 people)
  • Hypertension (2 people)

Top co-used drugs for these people *:

  • Zometa (20 people)
  • Chemotherapeutics Nos (19 people)
  • Red Blood Cells (18 people)
  • Radiation Therapy (18 people)
  • Aloxi (18 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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