Review: could Levothyroxine Sodium cause Heartburn?


Heartburn is found among people who take Levothyroxine Sodium, especially for people who are female, 50-59 old , have been taking the drug for 10+ years, also take medication Omeprazole, and have Hypothyroidism . We study 65,372 people who have side effects while taking Levothyroxine sodium from FDA and social media. Among them, 91 have Heartburn. Find out below who they are, when they have Heartburn and more.

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Levothyroxine Sodium

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Levothyroxine sodium 68,990 users)


Heartburn has been reported by people with breathing difficulty, abdominal pain, diarrhea, memory loss, fatigue (latest reports from 17,083 Heartburn patients).

On Aug, 29, 2016

65,372 people reported to have side effects when taking Levothyroxine Sodium.
Among them, 91 people (0.14%) have Heartburn

Number of reports submitted per year:

Could Levothyroxine sodium cause Heartburn?

Time on Levothyroxine Sodium when people have Heartburn *:

  • < 1 month: 4.55 %
  • 1 - 6 months: 4.55 %
  • 6 - 12 months: 9.09 %
  • 1 - 2 years: 9.09 %
  • 2 - 5 years: 4.55 %
  • 5 - 10 years: 31.82 %
  • 10+ years: 36.36 %

Gender of people who have Heartburn when taking Levothyroxine Sodium *:

  • female: 84.27 %
  • male: 15.73 %

Age of people who have Heartburn when taking Levothyroxine Sodium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 2.53 %
  • 30-39: 12.66 %
  • 40-49: 22.78 %
  • 50-59: 36.71 %
  • 60+: 25.32 %

Severity if Heartburn when taking Levothyroxine Sodium **:

  • least: 5 %
  • moderate: 60 %
  • severe: 30 %
  • most severe: 5 %

How people recovered from Heartburn **:

  • while on drug: 0.0 %
  • after off the drug: 33.33 %
  • not yet: 66.67 %

Top conditions involved for these people *:

  • Hypothyroidism (25 people)
  • Hypertension (15 people)
  • Depression (13 people)
  • Thyroid Disorder (10 people)
  • Uterine Leiomyoma (8 people)

Top co-used drugs for these people *:

  • Omeprazole (12 people)
  • Synthroid (11 people)
  • Protonix (11 people)
  • Premarin (10 people)
  • Advair Diskus 100/50 (10 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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