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Review: could Lisinopril cause Restless leg syndrome?

Summary: Restless leg syndrome is found among people who take Lisinopril, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months, also take medication Aspirin, and have High blood pressure.

We study 93,797 people who have side effects while taking Lisinopril from FDA and social media. Among them, 228 have Restless leg syndrome. Find out below who they are, when they have Restless leg syndrome and more.

You are not alone: join a support group for people who take Lisinopril and have Restless leg syndrome >>>



Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. (latest outcomes from 99,275 Lisinopril users)

Restless leg syndrome

Restless leg syndrome (a powerful urge to move your legs) has been reported by people with osteoporosis, depression, pain, high blood pressure, stress and anxiety. (latest reports from 17,498 Restless leg syndrome patients)

On Mar, 16, 2015: 93,797 people reported to have side effects when taking Lisinopril. Among them, 228 people (0.24%) have Restless Leg Syndrome.

Trend of Restless leg syndrome in Lisinopril reports

Time on Lisinopril when people have Restless leg syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless leg syndrome0.00%9.52%33.33%14.29%28.57%9.52%4.76%

Gender of people who have Restless leg syndrome when taking Lisinopril * :

Restless leg syndrome54.87%45.13%

Age of people who have Restless leg syndrome when taking Lisinopril * :

Restless leg syndrome0.00%0.00%0.00%0.53%7.49%8.02%34.76%49.20%

Severity of Restless leg syndrome when taking Lisinopril ** :

leastmoderateseveremost severe
Restless leg syndrome6.67%40.00%33.33%20.00%

How people recovered from Restless leg syndrome ** :

while on the drugafter off the drugnot yet
Restless leg syndrome0.00%50.00%50.00%

Top conditions involved for these people * :

  1. Hypertension (38 people, 16.67%)
  2. Restless legs syndrome (37 people, 16.23%)
  3. Depression (36 people, 15.79%)
  4. Sleep disorder (33 people, 14.47%)
  5. Anxiety (21 people, 9.21%)

Top co-used drugs for these people * :

  1. Aspirin (73 people, 32.02%)
  2. Ambien (64 people, 28.07%)
  3. Hydrochlorothiazide (62 people, 27.19%)
  4. Lipitor (55 people, 24.12%)
  5. Neurontin (55 people, 24.12%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

Comments for this study:

Dr. Pamela Hamilton-Stubbs (1 year ago):

Very interesting. As a member of the International Willis Ekbom Disease Study Group (formerly the RLS Study Group) I was not familiar with this association. I am passing this on to other members of the study group.
Reply the comment

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you have Restless Leg Syndrome while taking Lisinopril?




You are not alone! Join a mobile support group on :
- support group for people who take Lisinopril and have Restless Leg Syndrome
- support group for people who take Lisinopril
- support group for people who have Restless Leg Syndrome

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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