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Review: could Lisinopril cause Restless leg syndrome?

Summary: Restless leg syndrome could be caused by Lisinopril, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months, also take Aspirin, and have Hypertension.

We study 93,292 people who have side effects while taking Lisinopril from FDA and social media. Among them, 228 have Restless leg syndrome. Find out below who they are, when they have Restless leg syndrome and more.

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Lisinopril

Lisinopril (latest outcomes from 98,719 users) has active ingredients of lisinopril. It is often used in high blood pressure.

Restless leg syndrome

Restless leg syndrome (a powerful urge to move your legs) (latest reports from 67,446 patients) has been reported by people with osteoporosis, depression, high blood pressure, pain, stress and anxiety.

On Apr, 10, 2014: 93,323 people reported to have side effects when taking Lisinopril. Among them, 228 people (0.24%) have Restless Leg Syndrome. They amount to 0.34% of all the 67,313 people who have Restless Leg Syndrome on eHealthMe.

Trend of Restless leg syndrome in Lisinopril reports

Time on Lisinopril when people have Restless leg syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless leg syndrome0.00%9.52%33.33%14.29%28.57%9.52%4.76%

Gender of people who have Restless leg syndrome when taking Lisinopril * :

FemaleMale
Restless leg syndrome54.87%45.13%

Age of people who have Restless leg syndrome when taking Lisinopril * :

0-12-910-1920-2930-3940-4950-5960+
Restless leg syndrome0.00%0.00%0.00%0.53%7.49%8.02%34.76%49.20%

Severity of Restless leg syndrome when taking Lisinopril ** :

leastmoderateseveremost severe
Restless leg syndrome6.67%40.00%33.33%20.00%

How people recovered from Restless leg syndrome ** :

while on the drugafter off the drugnot yet
Restless leg syndrome0.00%50.00%50.00%

Top conditions involved for these people * :

  1. Hypertension (38 people, 16.67%)
  2. Restless legs syndrome (37 people, 16.23%)
  3. Depression (36 people, 15.79%)
  4. Sleep disorder (33 people, 14.47%)
  5. Anxiety (21 people, 9.21%)

Top co-used drugs for these people * :

  1. Aspirin (73 people, 32.02%)
  2. Ambien (64 people, 28.07%)
  3. Hydrochlorothiazide (62 people, 27.19%)
  4. Neurontin (55 people, 24.12%)
  5. Lipitor (55 people, 24.12%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

Comments for this study:

Dr. Pamela Hamilton-Stubbs (6 months ago):

Very interesting. As a member of the International Willis Ekbom Disease Study Group (formerly the RLS Study Group) I was not familiar with this association. I am passing this on to other members of the study group.
Reply the comment

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Related topic: Lisinopril, Restless leg syndrome

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On eHealthMe, Lisinopril (lisinopril) is often used for high blood pressure. Find out below the conditions Lisinopril is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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Comments from related studies:

  • From this study (1 month ago):

  • It's uncomfortable for me to sleep at night and what can I do about it

    Reply

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

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