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Review: could Lortab cause Rls (Restless leg syndrome)?

Summary: Rls is found among people who take Lortab, especially for people who are female, 60+ old, also take medication Zometa, and have Neoplasm malignant.

We study 15,761 people who have side effects while taking Lortab from FDA and social media. Among them, 158 have Rls. Find out below who they are, when they have Rls and more.

You are not alone: join a support group for people who take Lortab and have Rls >>>



Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from 17,017 Lortab users)


Rls (restless legs syndrome) has been reported by people with osteoporosis, depression, pain, high blood pressure, stress and anxiety. (latest reports from 17,498 Rls patients)

On Mar, 27, 2015: 15,757 people reported to have side effects when taking Lortab. Among them, 158 people (1.00%) have Rls.

Trend of Rls in Lortab reports

Time on Lortab when people have Rls * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Rls when taking Lortab * :


Age of people who have Rls when taking Lortab * :


Severity of Rls when taking Lortab ** :

leastmoderateseveremost severe

How people recovered from Rls ** :

while on the drugafter off the drugnot yet

Top conditions involved for these people * :

  1. Neoplasm malignant (29 people, 18.35%)
  2. Lung neoplasm (29 people, 18.35%)
  3. Metastases to spine (29 people, 18.35%)
  4. Depression (28 people, 17.72%)
  5. Calcium deficiency (28 people, 17.72%)

Top co-used drugs for these people * :

  1. Zometa (101 people, 63.92%)
  2. Coumadin (89 people, 56.33%)
  3. Ambien (79 people, 50.00%)
  4. Nexium (60 people, 37.97%)
  5. Lasix (56 people, 35.44%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of lortab and rls on

Do you have Rls while taking Lortab?




You are not alone! Join a support group on :
- support group for people who take Lortab and have Rls
- support group for people who take Lortab
- support group for people who have Rls

Drugs in real world that are associated with:

Could your condition cause:

Recent related drug studies (Check your drugs):

Recent Lortab related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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