Review: could Lyrica cause Lethargy (Fatigue)?
Summary: Lethargy is found among people who take Lyrica, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Neurontin, and have Pain.
We study 64,396 people who have side effects while taking Lyrica from FDA and social media. Among them, 3,403 have Lethargy. Find out below who they are, when they have Lethargy and more.
You are not alone: join a mobile support group for people who take Lyrica and have Lethargy >>>
Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from 66,603 Lyrica users)
Lethargy (tiredness) has been reported by people with multiple sclerosis, high blood pressure, depression, rheumatoid arthritis, osteoporosis. (latest reports from 200,647 Lethargy patients)
On Feb, 4, 2015: 64,375 people reported to have side effects when taking Lyrica. Among them, 3,401 people (5.28%) have Lethargy.
Time on Lyrica when people have Lethargy * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
Gender of people who have Lethargy when taking Lyrica * :
Age of people who have Lethargy when taking Lyrica * :
Severity of Lethargy when taking Lyrica ** :
|least||moderate||severe||most severe |
How people recovered from Lethargy ** :
|while on the drug||after off the drug||not yet |
Top conditions involved for these people * :
- Pain (842 people, 24.76%)
- Fibromyalgia (805 people, 23.67%)
- Neuralgia (487 people, 14.32%)
- Depression (421 people, 12.38%)
- Anxiety (326 people, 9.59%)
Top co-used drugs for these people * :
- Neurontin (460 people, 13.53%)
- Cymbalta (451 people, 13.26%)
- Aspirin (441 people, 12.97%)
- Ambien (336 people, 9.88%)
- Synthroid (309 people, 9.09%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
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Do you have Lethargy while taking Lyrica?
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I have gained about 35 pounds, and I have the cognitive effects listed in the prescribing information--problems with thinking and concentration." I've been off Lyrica once, and the side effects went away, but I couldn't get out of bed in the morning
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- 3 strong drugs together against neuropathic pain
Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.
The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.
The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.
It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.
There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.
Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.
The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).
Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.
I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
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Comments from related studies:
From this study (1 year ago):
I started taking Lyrica back in 2008, and started having Cushing-like symptoms the same year, but my doctors at the va thought it was related to a nodule that was found on the left adrenal gland around the same time. I have been bounced from specialist to specialist for years, and my labs come back normal almost every time; however, there is significant weight gain (even though I hepcat healthy and attempt to exercise), and I am growing again (at 36). Last time I checked I was 5'11.5 and a few months ago I was bed ridden with leg/knee pain. I am now 6'2 even.
From this study (1 year ago):
Nausea...sensitive to light/noise.. headaches/migraines ..pain in joints.. very weak..unstable on feet... fatigue..sweating..ringing ears...tingly feet and hands
Poor eye sight...
From this study (1 year ago):
pins and needles in hands, arms, legs and feet.
numb hands / arms
painful stiff back
difficulty walking due to heavy painful legs and back
poor short term memory and some confusion.
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