Review: could Melatonin cause Serotonin syndrome?
Summary: Serotonin syndrome could be caused by Melatonin, especially for people who are female, 60+ old, also take Zyvox, and have Depression.
We study 2,128 people who have side effects while taking Melatonin from FDA and social media. Among them, 6 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.
How are my drugs for patients like me? On eHealthMe, you can research 300 million drug outcomes from FDA and social media. All studies are personalized to gender and age. Start now, it's anonymous, simple & free >>>
Melatonin (latest outcomes from 2,573 users) has active ingredients of melatonin. It is often used in insomnia, sleep disorder. Commonly reported side effects of Melatonin include fatigue, pain, pain exacerbated, fatigue aggravated, nausea.
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,373 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.
On Apr, 6, 2014: 2,159 people reported to have side effects when taking Melatonin. Among them, 6 people (0.28%) have Serotonin Syndrome. They amount to 0.02% of all the 34,351 people who have Serotonin Syndrome on eHealthMe.
Time on Melatonin when people have Serotonin syndrome * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Serotonin syndrome||0.00||0.00||0.00||0.00||0.00||0.00||0.00 |
Gender of people who have Serotonin syndrome when taking Melatonin * :
|Serotonin syndrome||83.33%||16.67% |
Age of people who have Serotonin syndrome when taking Melatonin * :
|Serotonin syndrome||0.00%||0.00%||0.00%||16.67%||0.00%||33.33%||0.00%||50.00% |
Severity of Serotonin syndrome when taking Melatonin ** :
|least||moderate||severe||most severe |
|Serotonin syndrome||0.00%||100.00%||0.00%||0.00% |
How people recovered from Serotonin syndrome ** :
|while on the drug||after off the drug||not yet |
|Serotonin syndrome||0.00%||0.00%||100.00% |
Top conditions involved for these people * :
- Depression (4 people, 66.67%)
- Pain (2 people, 33.33%)
- Pneumonia (2 people, 33.33%)
- Hypertension (2 people, 33.33%)
- Pyrexia (2 people, 33.33%)
Top co-used drugs for these people * :
- Zyvox (3 people, 50.00%)
- Lopressor (3 people, 50.00%)
- Zoloft (3 people, 50.00%)
- Lisinopril (2 people, 33.33%)
- Mirapex (2 people, 33.33%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Related topic: Melatonin, Serotonin syndrome
You can also:
On eHealthMe, Melatonin (melatonin) is often used for insomnia. Find out below the conditions Melatonin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.
What is Melatonin used for and how effective is it:
Other drugs that are used to treat the same conditions:
Could it be a symptom from a condition:
Drugs in real world that are associated with:
Could your condition cause it?
Comments from related studies:
From this study (2 years ago):
Had it since Saturday. Having Anxiety attacks, then randomly in a good mood, my brain feels like it's going on overdrive, constantly feeling like I've been here before. Face muscles contract and relax spuriously, and have thoughts of death.
Julie on Oct, 14, 2012:
I ALSO have that happen to me, every single time I take a Tizanidine. I start thinking about death and become very afraid. It's a scary feeling; indescribable.
NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.