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Review: could Melatonin cause Serotonin syndrome?

Summary: Serotonin syndrome could be caused by Melatonin, especially for people who are female, 60+ old, also take Zyvox, and have Depression.

We study 2,128 people who have side effects while taking Melatonin from FDA and social media. Among them, 6 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

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Melatonin

Melatonin (latest outcomes from 2,573 users) has active ingredients of melatonin. It is often used in insomnia, sleep disorder. Commonly reported side effects of Melatonin include fatigue, pain, pain exacerbated, fatigue aggravated, nausea.

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,373 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.

On Apr, 6, 2014: 2,159 people reported to have side effects when taking Melatonin. Among them, 6 people (0.28%) have Serotonin Syndrome. They amount to 0.02% of all the 34,351 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Melatonin reports

Time on Melatonin when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome0.000.000.000.000.000.000.00

Gender of people who have Serotonin syndrome when taking Melatonin * :

FemaleMale
Serotonin syndrome83.33%16.67%

Age of people who have Serotonin syndrome when taking Melatonin * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%0.00%16.67%0.00%33.33%0.00%50.00%

Severity of Serotonin syndrome when taking Melatonin ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%100.00%0.00%0.00%

How people recovered from Serotonin syndrome ** :

while on the drugafter off the drugnot yet
Serotonin syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (4 people, 66.67%)
  2. Pain (2 people, 33.33%)
  3. Pneumonia (2 people, 33.33%)
  4. Hypertension (2 people, 33.33%)
  5. Pyrexia (2 people, 33.33%)

Top co-used drugs for these people * :

  1. Zyvox (3 people, 50.00%)
  2. Lopressor (3 people, 50.00%)
  3. Zoloft (3 people, 50.00%)
  4. Lisinopril (2 people, 33.33%)
  5. Mirapex (2 people, 33.33%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Melatonin, Serotonin syndrome

You can also:

On eHealthMe, Melatonin (melatonin) is often used for insomnia. Find out below the conditions Melatonin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Melatonin used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (2 years ago):

  • Had it since Saturday. Having Anxiety attacks, then randomly in a good mood, my brain feels like it's going on overdrive, constantly feeling like I've been here before. Face muscles contract and relax spuriously, and have thoughts of death.

    Reply

    Julie on Oct, 14, 2012:

    I ALSO have that happen to me, every single time I take a Tizanidine. I start thinking about death and become very afraid. It's a scary feeling; indescribable.

    Reply

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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- Melatonin side effects

 

Related symptom

- Serotonin Syndrome

 

 

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