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Review: could Metformin hydrochloride cause Drug not working (Drug Ineffective)?

Summary: Drug not working is found among people who take Metformin hydrochloride, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Simvastatin, and have Diabetes.

We study 12,773 people who have side effects while taking Metformin hydrochloride from FDA and social media. Among them, 337 have Drug not working. Find out below who they are, when they have Drug not working and more.

You are not alone: join a support group for people who take Metformin hydrochloride and have Drug not working >>>


Metformin hydrochloride

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from 14,614 Metformin hydrochloride users)

Drug not working

On Mar, 6, 2015: 12,773 people reported to have side effects when taking Metformin hydrochloride. Among them, 337 people (2.64%) have Drug Not Working.

Trend of Drug not working in Metformin hydrochloride reports

Time on Metformin hydrochloride when people have Drug not working * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Drug not working25.00%33.33%8.33%8.33%16.67%8.33%0.00%

Gender of people who have Drug not working when taking Metformin hydrochloride * :

Drug not working53.92%46.08%

Age of people who have Drug not working when taking Metformin hydrochloride * :

Drug not working0.00%0.00%1.19%0.79%3.95%10.67%28.85%54.55%

Top conditions involved for these people * :

  1. Diabetes mellitus (80 people, 23.74%)
  2. Hypertension (57 people, 16.91%)
  3. Type 2 diabetes mellitus (48 people, 14.24%)
  4. Blood cholesterol increased (21 people, 6.23%)
  5. Pain (20 people, 5.93%)

Top co-used drugs for these people * :

  1. Simvastatin (47 people, 13.95%)
  2. Byetta (33 people, 9.79%)
  3. Lipitor (32 people, 9.50%)
  4. Aspirin (31 people, 9.20%)
  5. Lantus (31 people, 9.20%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Drug Not Working while taking Metformin Hydrochloride?




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- support group for people who take Metformin hydrochloride and have Drug Not Working
- support group for people who take Metformin hydrochloride

Drugs in real world that are associated with:

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Recent Metformin hydrochloride related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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