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Related topic: Metformin hydrochloride, Kidney stones

Review: could Metformin cause Kidney stones?

Summary: Kidney stones could be caused by Metformin, especially for people who are female, 50-59 old, also take Aspirin, and have Diabetes mellitus.

We study 12,739 people who have side effects while taking Metformin from FDA and social media. Among them, 76 have Kidney stones. Find out below who they are, when they have Kidney stones and more.

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Metformin hydrochloride

Metformin hydrochloride (latest outcomes from 14,580 users) has active ingredients of metformin hydrochloride. It is often used in diabetes.

Kidney stones

Kidney stones (latest reports from 105,426 patients) has been reported by people with multiple sclerosis, osteoporosis, high blood pressure, rheumatoid arthritis, pain.

On Apr, 15, 2014: 12,739 people reported to have side effects when taking Metformin hydrochloride. Among them, 76 people (0.60%) have Kidney Stones. They amount to 0.07% of all the 105,226 people who have Kidney Stones on eHealthMe.

Trend of Kidney stones in Metformin hydrochloride reports

Time on Metformin hydrochloride when people have Kidney stones * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Kidney stones0.00%12.50%0.00%0.00%25.00%12.50%50.00%

Gender of people who have Kidney stones when taking Metformin hydrochloride * :

FemaleMale
Kidney stones51.85%48.15%

Age of people who have Kidney stones when taking Metformin hydrochloride * :

0-12-910-1920-2930-3940-4950-5960+
Kidney stones0.00%0.00%0.00%0.00%5.66%22.64%39.62%32.08%

Severity of Kidney stones when taking Metformin hydrochloride ** :

leastmoderateseveremost severe
Kidney stones0.00%0.00%100.00%0.00%

How people recovered from Kidney stones ** :

while on the drugafter off the drugnot yet
Kidney stones0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Diabetes mellitus (17 people, 22.37%)
  2. Metastatic neoplasm (13 people, 17.11%)
  3. Type 2 diabetes mellitus (12 people, 15.79%)
  4. Breast cancer metastatic (11 people, 14.47%)
  5. Hypersensitivity (10 people, 13.16%)

Top co-used drugs for these people * :

  1. Aspirin (27 people, 35.53%)
  2. Zometa (23 people, 30.26%)
  3. Colace (19 people, 25.00%)
  4. Crestor (19 people, 25.00%)
  5. Insulin (18 people, 23.68%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

Comments for this study:

Wil (1 year ago):

UPDATE: August and September 2012 had Lithotripsy for two large stones. Also stopped Metformin after consultation with Dr and reevaluation of the need. next recheck due in May 2013
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Kenneth Cruthis (1 year ago):

I am seventy years old and in pretty good health, I am borderline type two diabetic. My doctor prescribed Metphormin and within a week I was passing multiple small kidney stones and after about a week , still passing stones, then I quit for a couple of weeks and the stones subsided, then I started taking the drug again and the stones started back up again, now I have had a history of stones in the past but nothing as frequent as this. I started taking 2000 mg. of Calcium each day and haven't been bothered with stones in several years until I started taking Metphormin. This is the only Generic drug that I know of for non insulin dependent diabetes. I may try it again for another test. I have decided that my health is my reasonability with loosing weight, diet and exercise.
Reply the comment

Wil (3 years ago):

I have been on Metformin 250mg twice daily for about 7 months. My first ever kidney stone event occured at 5 months with a second event at 7 months. Metformin was the replacement for Avandia which I had taken for years without incident. I am 68 years old.
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Kreese (3 years ago):

I was diagnosed Type 2 diabetic late 2010 and started onn Medformin 250 mg twice a day. very strange that my blood sugars were normal afdter 1 week on the meds and continued to be normal even after having a none fasting blood sugar and A1C done, which were all normal as well.

Recently I had kidney stones from hell and was rushed to the hospital after being on Medformin for 6 Months.

Being in the pharmaceutcal field I am convinced that Medformin causes Kidney Stones. Drug companies do not report all side affects from clinical trials to the FDA, this I can tell you they use the data that is good for them to get their dug approved. I am sure that the numbers are higher for people developing kidney stones from Medformin.
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On eHealthMe, Metformin Hydrochloride (metformin hydrochloride) is often used for diabetes. Find out below the conditions Metformin Hydrochloride is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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  • Cardiac triple bypass surgery on 13January 2009.

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