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Review: could Metformin cause Brain injury (Head injury)?

Summary: Brain injury is found among people who take Metformin, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Metformin hcl, and have Diabetes.

We study 97,507 people who have side effects while taking Metformin from FDA and social media. Among them, 750 have Brain injury. Find out below who they are, when they have Brain injury and more.

You are not alone: join a support group for people who take Metformin and have Brain injury >>>



Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from 101,041 Metformin users)

Brain injury

Brain injury has been reported by people with osteoporosis, multiple sclerosis, rheumatoid arthritis, depression, high blood pressure. (latest reports from 38,342 Brain injury patients)

On Apr, 14, 2015: 97,488 people reported to have side effects when taking Metformin. Among them, 750 people (0.77%) have Brain Injury.

Trend of Brain injury in Metformin reports

Time on Metformin when people have Brain injury * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Brain injury0.00%25.00%4.17%12.50%33.33%25.00%0.00%

Gender of people who have Brain injury when taking Metformin * :

Brain injury64.80%35.20%

Age of people who have Brain injury when taking Metformin * :

Brain injury0.00%0.15%0.30%1.52%1.52%11.11%24.96%60.43%

Severity of Brain injury when taking Metformin ** :


How people recovered from Brain injury ** :


Top conditions involved for these people * :

  1. Diabetes mellitus (202 people, 26.93%)
  2. Hypertension (124 people, 16.53%)
  3. Type 2 diabetes mellitus (94 people, 12.53%)
  4. Breast cancer metastatic (65 people, 8.67%)
  5. Blood cholesterol increased (59 people, 7.87%)

Top co-used drugs for these people * :

  1. Metformin hcl (560 people, 74.67%)
  2. Aspirin (285 people, 38.00%)
  3. Lasix (132 people, 17.60%)
  4. Avandia (121 people, 16.13%)
  5. Metformin hydrochloride (114 people, 15.20%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of metformin and brain injury on

Do you have Brain Injury while taking Metformin?




You are not alone! Join a support group on :
- support group for people who take Metformin and have Brain Injury
- support group for people who take Metformin
- support group for people who have Brain Injury

Drugs in real world that are associated with:

Could your condition cause:

Recent related drug studies (Check your drugs):

Recent Metformin related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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