Review: could Metformin cause Fatigue?


Summary

Fatigue is found among people who take Metformin, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Lisinopril, and have Diabetes mellitus . We study 84,420 people who have side effects while taking Metformin from FDA and social media. Among them, 4,041 have Fatigue. Find out below who they are, when they have Fatigue and more.

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Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 174,670 users)

Fatigue

Fatigue (feeling of tiredness) has been reported by people with breathing difficulty, pain, weakness, insomnia, stress and anxiety (latest reports from 346,068 Fatigue patients).

On Sep, 16, 2016

84,420 people reported to have side effects when taking Metformin.
Among them, 4,041 people (4.79%) have Fatigue


Number of reports submitted per year:

Could Metformin cause Fatigue?

Time on Metformin when people have Fatigue *:

  • < 1 month: 15.48 %
  • 1 - 6 months: 20.65 %
  • 6 - 12 months: 8.39 %
  • 1 - 2 years: 10.32 %
  • 2 - 5 years: 29.68 %
  • 5 - 10 years: 10.32 %
  • 10+ years: 5.16 %

Gender of people who have Fatigue when taking Metformin *:

  • female: 56.11 %
  • male: 43.89 %

Age of people who have Fatigue when taking Metformin *:

  • 0-1: 0.0 %
  • 2-9: 0.09 %
  • 10-19: 0.44 %
  • 20-29: 1.62 %
  • 30-39: 4.25 %
  • 40-49: 9.74 %
  • 50-59: 25.07 %
  • 60+: 58.79 %

Severity if Fatigue when taking Metformin **:

  • least: 4.55 %
  • moderate: 48.48 %
  • severe: 40.91 %
  • most severe: 6.06 %

How people recovered from Fatigue **:

  • while on drug: 3.85 %
  • after off the drug: 1.92 %
  • not yet: 94.23 %

Top conditions involved for these people *:

  • Diabetes Mellitus (976 people, 24.15%)
  • Hypertension (596 people, 14.75%)
  • Type 2 Diabetes Mellitus (541 people, 13.39%)
  • Blood Cholesterol Increased (262 people, 6.48%)
  • Hepatitis C (235 people, 5.82%)

Top co-used drugs for these people *:

  • Lisinopril. (341 people, 8.44%)
  • Lisinopril (341 people, 8.44%)
  • Aspirin. (312 people, 7.72%)
  • Aspirin (305 people, 7.55%)
  • Amlodipine (289 people, 7.15%)

Top other side effects for these people *:

  • Nausea (873 people, 21.60%)
  • Asthenia (628 people, 15.54%)
  • Diarrhoea (595 people, 14.72%)
  • Dizziness (546 people, 13.51%)
  • Dyspnoea (529 people, 13.09%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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