Review: could Metformin cause Joint Pain?


Joint pain is found among people who take Metformin, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Humira, and have Diabetes mellitus . We study 41,587 people who have side effects while taking Metformin from FDA and social media. Among them, 962 have Joint pain. Find out below who they are, when they have Joint pain and more.

You are not alone

Join a support group for people who take Metformin and have Joint pain >>>

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 117,555 users)

Joint Pain

Joint pain has been reported by people with breathing difficulty, pain, drug ineffective, stroke, chest pain (latest reports from 133,619 Joint pain patients).

On Aug, 23, 2016

41,587 people reported to have side effects when taking Metformin.
Among them, 962 people (2.31%) have Joint Pain

Number of reports submitted per year:

Could Metformin cause Joint pain?

Time on Metformin when people have Joint Pain *:

  • < 1 month: 8.33 %
  • 1 - 6 months: 11.11 %
  • 6 - 12 months: 11.11 %
  • 1 - 2 years: 13.89 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 19.44 %
  • 10+ years: 2.78 %

Gender of people who have Joint Pain when taking Metformin *:

  • female: 63.99 %
  • male: 36.01 %

Age of people who have Joint Pain when taking Metformin *:

  • 0-1: 0.13 %
  • 2-9: 0.13 %
  • 10-19: 0.4 %
  • 20-29: 1.06 %
  • 30-39: 3.71 %
  • 40-49: 13.51 %
  • 50-59: 29.27 %
  • 60+: 51.79 %

Severity if Joint Pain when taking Metformin **:

  • least: 0.0 %
  • moderate: 52 %
  • severe: 40 %
  • most severe: 8 %

How people recovered from Joint Pain **:

  • while on drug: 0.0 %
  • after off the drug: 4.76 %
  • not yet: 95.24 %

Top conditions involved for these people *:

  • Diabetes Mellitus (279 people)
  • Hypertension (180 people)
  • Rheumatoid Arthritis (160 people)
  • Blood Cholesterol Increased (102 people)
  • Type 2 Diabetes Mellitus (93 people)

Top co-used drugs for these people *:

  • Humira (164 people)
  • Lisinopril (162 people)
  • Aspirin (154 people)
  • Simvastatin (134 people)
  • Lipitor (104 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Joint pain when taking Metformin?

Recent conversations of related support groups:

Browse all side effects of Metformin

a b c d e f g h i j k l m n o p q r s t u v w x y z

Drugs that are associated with Joint pain

Joint pain

Could your condition cause Joint pain

Joint pain

Can you answer these questions?

More questions for: Metformin, Joint pain

You may be interested in these reviews

More reviews for: Metformin, Joint pain

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.