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Review: could Metformin cause Joint pain?

Summary: Joint pain could be caused by Metformin, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Metformin hcl, and have Diabetes mellitus.

We study 97,041 people who have side effects while taking Metformin from FDA and social media. Among them, 1,796 have Joint pain. Find out below who they are, when they have Joint pain and more.

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Metformin

Metformin (latest outcomes from 100,539 users) has active ingredients of metformin hydrochloride. It is often used in type 2 diabetes, polycystic ovary disease. Commonly reported side effects of Metformin include blood glucose increased, nausea aggravated, nausea, weight decreased, diarrhea.

Joint pain

Joint pain (latest reports from 795,725 patients) has been reported by people with rheumatoid arthritis, osteoporosis, high blood pressure, high blood cholesterol, multiple sclerosis.

On Apr, 14, 2014: 97,041 people reported to have side effects when taking Metformin. Among them, 1,793 people (1.85%) have Joint Pain. They amount to 0.23% of all the 795,376 people who have Joint Pain on eHealthMe.

Trend of Joint pain in Metformin reports

Time on Metformin when people have Joint pain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Joint pain17.31%26.92%9.62%1.92%23.08%19.23%1.92%

Gender of people who have Joint pain when taking Metformin * :

FemaleMale
Joint pain62.07%37.93%

Age of people who have Joint pain when taking Metformin * :

0-12-910-1920-2930-3940-4950-5960+
Joint pain0.13%0.00%0.46%0.93%4.63%14.42%29.10%50.33%

Severity of Joint pain when taking Metformin ** :

leastmoderateseveremost severe
Joint pain0.00%66.67%33.33%0.00%

How people recovered from Joint pain ** :

while on the drugafter off the drugnot yet
Joint pain0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Diabetes mellitus (348 people, 19.41%)
  2. Hypertension (230 people, 12.83%)
  3. Type 2 diabetes mellitus (188 people, 10.49%)
  4. Rheumatoid arthritis (162 people, 9.04%)
  5. Depression (150 people, 8.37%)

Top co-used drugs for these people * :

  1. Metformin hcl (1,093 people, 60.96%)
  2. Aspirin (455 people, 25.38%)
  3. Lisinopril (299 people, 16.68%)
  4. Lipitor (228 people, 12.72%)
  5. Simvastatin (222 people, 12.38%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Metformin, Joint pain

You can also:

On eHealthMe, Metformin (metformin hydrochloride) is often used for type 2 diabetes. Find out below the conditions Metformin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Metformin used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (6 months ago):

  • headaches and fatigue seem to come and go throughout the day.

    Reply

  • From this study (2 years ago):

  • Joint pain in various joints....alternates hands, leg, toes, fingers, knees, shoulder

    Reply

    Juliana on Oct, 5, 2012:

    me too. I also had pleurisy and pericarditis. Write me please: leakel@gmail ! Thanks Juliana 31 years.

    Reply

    Lana on Oct, 15, 2012:

    yeap... occasionally cough up blood, due to extreme cold weather (Chicago)- and sometimes pain in the upper back area.. and yes stress - and I also have joint pain.. I've had 4 CT lung scans, all normal. Female, 60yr old (but had this problem for years & on occasions only)

    Reply

  • From this study (2 years ago):

  • Missed my dose of metformin last night and today no more joint pain.

    Reply

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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