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Review: could Metformin cause Joint pain?

We study 97,239 people who have side effects while taking Metformin from FDA and social media. Among them, 1,798 have Joint pain. Find out below who they are, when they have Joint pain and more.

Get connected: join a mobile support group for people who take Metformin and have Joint pain >>>

Metformin

Metformin (latest outcomes from 100,768 users) has active ingredients of metformin hydrochloride. It is often used in type 2 diabetes.

Joint pain

Joint pain (latest reports from 800,477 patients) has been reported by people with rheumatoid arthritis, osteoporosis, high blood pressure, high blood cholesterol, multiple sclerosis.

On Sep, 15, 2014: 97,239 people reported to have side effects when taking Metformin. Among them, 1,798 people (1.85%) have Joint Pain.

Trend of Joint pain in Metformin reports

Time on Metformin when people have Joint pain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Joint pain17.54%24.56%8.77%1.75%24.56%19.30%3.51%

Gender of people who have Joint pain when taking Metformin * :

FemaleMale
Joint pain62.17%37.83%

Age of people who have Joint pain when taking Metformin * :

0-12-910-1920-2930-3940-4950-5960+
Joint pain0.13%0.00%0.46%0.92%4.61%14.44%29.14%50.30%

Severity of Joint pain when taking Metformin ** :

leastmoderateseveremost severe
Joint pain0.00%65.62%34.38%0.00%

How people recovered from Joint pain ** :

while on the drugafter off the drugnot yet
Joint pain0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Diabetes mellitus (349 people, 19.41%)
  2. Hypertension (230 people, 12.79%)
  3. Type 2 diabetes mellitus (188 people, 10.46%)
  4. Rheumatoid arthritis (163 people, 9.07%)
  5. Depression (151 people, 8.40%)

Top co-used drugs for these people * :

  1. Metformin hcl (1,093 people, 60.79%)
  2. Aspirin (455 people, 25.31%)
  3. Lisinopril (300 people, 16.69%)
  4. Lipitor (228 people, 12.68%)
  5. Simvastatin (224 people, 12.46%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Joint Pain while taking Metformin?

Get connected! Join a mobile support group:
- group for people who take Metformin and have Joint Pain
- group for people who take Metformin
- group for people who have Joint Pain

Comments from related studies:

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  • Naprosyn, Vicodin, Ativan and Prilosec are taken only on an as needed basis. Some of my symptoms are intermittent, and some are chronic. The though the medications may not completely rid me of a symptom (for example, depression or muscle pain), they do improve my condition enough to warrant their continued use. I'm much better off taking them than not.

    The oral issues I'm having all began around the same time in the last year. I first noticed a sensitivity for spicy food I had never experienced. I can no longer use adult toothpaste because the minty flavors are so provinces as to cause pain. The gum irritation comes and goes as does the severity of the other oral pain I experience.

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  • From this study (1 month ago):

  • I've been diagnosed with sero-negative rheumatoid arthritis. I have only tested minimally positive on the anti-CCP test and had a slightly high SED rate. My most recent tests showed some slight elevation in some RA marker tests, but nothing really significant. My rheumatologist is now doubting whether I have RA or some other pain syndrome going on.

    Reply

    IHateRA on Jul, 22, 2014:

    My first RA Dr. put me on Plaquenil, it seemed to work for six months, then stopped - I thought the dose would be adjusted but it wasn't, so I went to another RA Doc - C-RP wasn't too high, sero neg. Was put on methotrexate - I ended up with a mouth sore the NEXT day, then bumps started appearing on my face, like zits, but NOT zits. I didn't touch them, but they ulcerated, left me full of scars on face, legs, etc - I have been OFF methotrexate for 5 years AND still have the same problem along with a daily fever (100+) and severe sweating - I knew the bumps were a sign of being allergic to Methotrexate, I quit it right away, called Dr. to get in - they told me 3 months (I was an established patient). In terms of fever and sweating, the ONLY thing I have in common with some of these posts and drug lists is METHOTREXATE - I wouldn't allow a pet to take it. I seem to have more in common with a friend who as MS - but my reg. doc doesn't listen to that. I can't take bio. drugs (live in "fungal" region), so I take pain medicine - as little as possible, I guess the Methotrexate is STILL messing with my body. I have a very good acupuncturist - when I told him that my Doc. wasn't "sure" about RA, he poked me (lightly) with his finger in two places and ask which hurt more. He confirmed the RA as it travels on certain meridians in Chinese medicine. Had I picked a different spot for hurting more, then we would have to figure out what I really had. My joints are deteriorating but now I'm afraid of the drugs for RA, so I just put up with and manage the pain (which is extreme) with pain meds, cold therapy (I love my cryo-cuff), and acupuncture. I wish that the side effects of RA drugs weren't as bad as they are! Leaving Cymbalta, Lyrica, Plaquenil and Methotrexate (all at different times) OUT of my body made me realize that they did affect me - I was "foggy" and sluggish mentally but didn't really notice it until I quit them.

    Reply

  • From this study (3 months ago):

  • Recurring extreme pain in joint of big toe. Lasts for 2 to three days, then subsides. Had lab work done and was told that my uric acid level was below level that would cause any gout symptoms. I have had two painful flare ups over the past two months, about 3 weeks apart.

    Reply

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More reviews for: Metformin, Joint pain

On eHealthMe, Metformin (metformin hydrochloride) is often used for diabetes. Find out below the conditions Metformin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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