Review: could Metformin cause Kidney failure?
(By eHealthMe on Mar, 2, 2014)
Severity ratings: 2.7/4
On a scale of 1 to 4: 1=least, 2=moderate, 3=severe, 4=most severe
We study 91,513 people who take Metformin. Among them, 2,016 have Kidney failure. See who they are, when they have Kidney failure and more. This review is based on reports from FDA and social media, and is updated regularly.
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Metformin (latest outcomes from 100,457 users) has active ingredients of metformin hydrochloride. It is often used in diabetes, type 2 diabetes. Commonly reported side effects of Metformin include blood glucose increased, nausea, nausea aggravated, weight decreased, nausea and vomiting.
Kidney failure (loss of kidney function) (latest reports from 425,730 patients) has been reported by people with high blood pressure, coronary artery bypass, multiple myeloma, diabetes, pain.
On Feb, 13, 2014: 91,358 people reported to have side effects when taking Metformin. Among them, 1,794 people (1.96%) have Kidney Failure.
Time on Metformin when people have Kidney failure * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Kidney failure||11.01%||22.94%||9.17%||14.68%||27.52%||2.75%||11.93% |
Gender of people who have Kidney failure when taking Metformin * :
|Kidney failure||47.99%||52.01% |
Age of people who have Kidney failure when taking Metformin * :
|Kidney failure||0.13%||0.06%||0.38%||0.31%||2.08%||10.20%||20.21%||66.62% |
Severity of Kidney failure when taking Metformin ** :
|least||moderate||severe||most severe |
|Kidney failure||0.00%||33.33%||66.67%||0.00% |
How people recovered from Kidney failure ** :
|while on the drug||after off the drug||not yet |
|Kidney failure||100.00%||0.00%||0.00% |
Top conditions involved for these people * :
- Diabetes mellitus (361 people, 20.12%)
- Type 2 diabetes mellitus (324 people, 18.06%)
- Hypertension (252 people, 14.05%)
- Diabetes mellitus non-insulin-dependent (77 people, 4.29%)
- Depression (74 people, 4.12%)
Top co-used drugs for these people * :
- Metformin hcl (1,305 people, 72.74%)
- Aspirin (424 people, 23.63%)
- Lisinopril (319 people, 17.78%)
- Lasix (264 people, 14.72%)
- Furosemide (237 people, 13.21%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Related topic: Metformin, Kidney failure
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On eHealthMe, Metformin (metformin hydrochloride) is often used for diabetes. Find out below the conditions Metformin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.
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From this study (12 months ago):
Marie L on Jun, 20, 2012:
I am a 54-year-old Caucasian woman who recently underwent removal of a benign brain tumor via general anesthetic. Although I advised the anesthesia staff that I had been taking lithium for about 30 years, at the time of my surgery, I didn't know that lithium should be discontinued at least 72 hours to two weeks before surgery to avoid dehydration and resulting diabetes insipidis (abnormal urination)which is known to cause blindness. After my surgery, I was unable to be awakened and went into a "metabolic encephalopathy" for about three weeks. When I woke up, I was blind in my right eye. According to my neurosurgeon, the reason for the coma was due to lithium being in my system. As a result, I have total, irreversible blindness in my right eye. My surgeon's position is that it was not from the surgery and, instead, the medical staff had to wait until the lithium was flushed out of my body. This NEVER should have happened. My sodium levels sky-rocketed along with my blood pressure and blood sugar. If I would have known all of this before surgery, I would not have taken my lithium for the prescribed amount of time and definitely would have advised the doctor and medical staff accordingly. If you are taking lithium and have a general anesthesia scheduled, be sure to advise your surgeon and the anesthesia staff that you want to discontinue lithium until after the surgery when your vital signs are stable. Good luck to you.
LOA/13 on Mar, 27, 2013:
Hi Marie L,
I am also a female 57yrs, and have been trying to manage my Bipolar since my very early years. I like you, had surgery and because it was emergency surgery, no one had my medical records. At that time I was taking Lithium, the outcome was sever infection which took over 8mos to counteract. I appreciate your candor with your disclosure, because up until now (15 years later) I was only told the infection was due to the nature of the surgery (being emergency). Which I concluded, it was my fault for the outcome. I always thought the surgeons simplistic reasoning for the infection was a means by which to not have to fully disclaim the actual Reason = Lithium in my blood stream. I required another surgery for a broken arm (six places), which was postpone for several weeks. Now it makes sence for the postponement, he wanted to make sure the Lithium was out of my blood prior. This other surgery went off without a hitch. When and were possible, I highly recommend people to wear Medic Alert Bracelets, listing the medications you are taking. Thanks for listening.
LOA/13 on Mar, 27, 2013:
Female, 57yrs, Bipolar, looking for any comments with reference to interation of the following daily dosage drugs and the introduction of Lamotrigine to my dialy regiment.
Seroquel 800mg, Metforin 2000mg, Vimovo 500/40mg, Tylenol 2000mg. My Doc now would like to introduce Lamotrigine as a counter measure to my mood swings.
Does anyone have comments of the interation of these 4 drugs with Lamotrigine?
Your current and introductional experiences of this drug is appreciated. Thanks
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