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Review: could Metformin cause Muscle atrophy?

Summary: Muscle atrophy could be caused by Metformin, especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years, also take Metformin hcl, and have Hypercholesterolaemia.

We study 97,041 people who have side effects while taking Metformin from FDA and social media. Among them, 115 have Muscle atrophy. Find out below who they are, when they have Muscle atrophy and more.

On Apr, 9, 2014: 97,138 people reported to have side effects when taking Metformin. Among them, 115 people (0.12%) have Muscle Atrophy. They amount to 0.31% of all the 36,853 people who have Muscle Atrophy on eHealthMe.

Trend of Muscle atrophy in Metformin reports

Time on Metformin when people have Muscle atrophy * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Muscle atrophy20.00%0.00%0.00%0.00%60.00%20.00%0.00%

Gender of people who have Muscle atrophy when taking Metformin * :

FemaleMale
Muscle atrophy38.26%61.74%

Age of people who have Muscle atrophy when taking Metformin * :

0-12-910-1920-2930-3940-4950-5960+
Muscle atrophy0.00%0.00%0.00%1.01%5.05%5.05%25.25%63.64%

Severity of Muscle atrophy when taking Metformin ** :

leastmoderateseveremost severe
Muscle atrophy0.00%66.67%33.33%0.00%

How people recovered from Muscle atrophy ** :

while on the drugafter off the drugnot yet
Muscle atrophy0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Hypercholesterolaemia (17 people, 14.78%)
  2. Pain (11 people, 9.57%)
  3. Blood cholesterol increased (11 people, 9.57%)
  4. Type 2 diabetes mellitus (10 people, 8.70%)
  5. Neoplasm malignant (9 people, 7.83%)

Top co-used drugs for these people * :

  1. Metformin hcl (82 people, 71.30%)
  2. Lipitor (25 people, 21.74%)
  3. Actos (22 people, 19.13%)
  4. Aspirin (20 people, 17.39%)
  5. Glyburide (17 people, 14.78%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Metformin, Muscle atrophy

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On eHealthMe, Metformin (metformin hydrochloride) is often used for diabetes. Find out below the conditions Metformin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Metformin used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (6 months ago):

  • I've lost 70 lbs in two years, 40 lbs. in the past year. I am having significant atrophy in my legs, specifically my right leg. As a 52 year old man, I cannot walk normally nor can I walk up stairs.

    Reply

  • From this study (5 years ago):

  • Was never a smoker, but have intense cravings for cigarettes and seek to smoke 5-10 per day. Unusually/easily emotional. Highly agitated - take 5 or more walks per day to try to relieve the feeling. Significantly changed behavior and misses social cues, so may continue to repeat questions or opinions.

    Behavioral and physical changes came on seemingly all at once, not gradually over time.

    Reply

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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