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Review: could Metformin cause Restless legs syndrome?

Summary: Restless legs syndrome could be caused by Metformin, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take Metformin hcl, and have Diabetes mellitus.

We study 97,041 people who have side effects while taking Metformin from FDA and social media. Among them, 168 have Restless legs syndrome. Find out below who they are, when they have Restless legs syndrome and more.

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Metformin

Metformin (latest outcomes from 100,539 users) has active ingredients of metformin hydrochloride. It is often used in diabetes.

Restless legs syndrome

Restless legs syndrome (a powerful urge to move your legs) (latest reports from 67,415 patients) has been reported by people with restless leg syndrome, osteoporosis, depression, high blood pressure, pain.

On Apr, 15, 2014: 97,041 people reported to have side effects when taking Metformin. Among them, 168 people (0.17%) have Restless Legs Syndrome. They amount to 0.25% of all the 68,094 people who have Restless Legs Syndrome on eHealthMe.

Trend of Restless legs syndrome in Metformin reports

Time on Metformin when people have Restless legs syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless legs syndrome0.00%9.09%18.18%27.27%0.00%36.36%9.09%

Gender of people who have Restless legs syndrome when taking Metformin * :

FemaleMale
Restless legs syndrome54.12%45.88%

Age of people who have Restless legs syndrome when taking Metformin * :

0-12-910-1920-2930-3940-4950-5960+
Restless legs syndrome0.00%0.00%0.00%0.72%10.07%15.11%28.78%45.32%

Severity of Restless legs syndrome when taking Metformin ** :

leastmoderateseveremost severe
Restless legs syndrome9.09%36.36%36.36%18.18%

How people recovered from Restless legs syndrome ** :

while on the drugafter off the drugnot yet
Restless legs syndrome0.00%75.00%25.00%

Top conditions involved for these people * :

  1. Diabetes mellitus (30 people, 17.86%)
  2. Restless legs syndrome (30 people, 17.86%)
  3. Gastrooesophageal reflux disease (20 people, 11.90%)
  4. Depression (19 people, 11.31%)
  5. Hypertension (19 people, 11.31%)

Top co-used drugs for these people * :

  1. Metformin hcl (97 people, 57.74%)
  2. Aspirin (58 people, 34.52%)
  3. Lisinopril (50 people, 29.76%)
  4. Lipitor (41 people, 24.40%)
  5. Nexium (34 people, 20.24%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Metformin, Restless legs syndrome

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On eHealthMe, Metformin (metformin hydrochloride) is often used for diabetes. Find out below the conditions Metformin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Metformin used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

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Could your condition cause it?

Comments from related studies:

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (11 months ago):

  • Hoorppat on Jun, 21, 2013:

    Profound Gloomy could be enduring objective been a bunch of chipboards and wires but they made it look fantastic.
    It looked blood-curdling and electrifying - like something out of 2001, a humongous, raven, supercool hard compel
    Abstruse Dismal could have well-grounded been a group of chipboards and wires but they made it look fantastic.
    It looked spine-chilling and exciting - like something missing of 2001, a monstrous, negro, supercool severe pilot

    Reply

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