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Review: could Metformin cause Restless legs syndrome (Restless leg syndrome)?

We study 97,314 people who have side effects while taking Metformin from FDA and social media. Among them, 168 have Restless legs syndrome. Find out below who they are, when they have Restless legs syndrome and more.

Get connected: join a mobile support group for people who take Metformin and have Restless legs syndrome >>>

Metformin

Metformin (latest outcomes from 100,800 users) has active ingredients of metformin hydrochloride. It is often used in diabetes.

Restless legs syndrome

Restless legs syndrome (a powerful urge to move your legs) (latest reports from 67,388 patients) has been reported by people with restless leg syndrome, osteoporosis, depression, high blood pressure, pain.

On Sep, 16, 2014: 97,239 people reported to have side effects when taking Metformin. Among them, 168 people (0.17%) have Restless Legs Syndrome.

Trend of Restless legs syndrome in Metformin reports

Time on Metformin when people have Restless legs syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless legs syndrome0.00%9.09%18.18%27.27%0.00%36.36%9.09%

Gender of people who have Restless legs syndrome when taking Metformin * :

FemaleMale
Restless legs syndrome54.12%45.88%

Age of people who have Restless legs syndrome when taking Metformin * :

0-12-910-1920-2930-3940-4950-5960+
Restless legs syndrome0.00%0.00%0.00%0.72%10.07%15.11%28.78%45.32%

Severity of Restless legs syndrome when taking Metformin ** :

leastmoderateseveremost severe
Restless legs syndrome9.09%36.36%36.36%18.18%

How people recovered from Restless legs syndrome ** :

while on the drugafter off the drugnot yet
Restless legs syndrome0.00%75.00%25.00%

Top conditions involved for these people * :

  1. Diabetes mellitus (30 people, 17.86%)
  2. Restless legs syndrome (30 people, 17.86%)
  3. Gastrooesophageal reflux disease (20 people, 11.90%)
  4. Depression (19 people, 11.31%)
  5. Hypertension (19 people, 11.31%)

Top co-used drugs for these people * :

  1. Metformin hcl (97 people, 57.74%)
  2. Aspirin (58 people, 34.52%)
  3. Lisinopril (50 people, 29.76%)
  4. Lipitor (41 people, 24.40%)
  5. Requip (34 people, 20.24%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Restless Legs Syndrome while taking Metformin?

Get connected! Join a mobile support group:
- support group for people who take Metformin and have Restless Legs Syndrome
- support group for people who take Metformin
- support group for people who have Restless Legs Syndrome

Comments from related studies:

  • From this study (8 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (8 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (2 years ago):

  • Paul on Nov, 9, 2012:

    Is there a link between someone who takes Nexium, Celebrex, Levothyroxin, and Symvastatin to Type II Diabetes?

    Reply

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On eHealthMe, Metformin (metformin hydrochloride) is often used for type 2 diabetes. Find out below the conditions Metformin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Metformin used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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