Review: could Metformin cause Restless legs syndrome (Restless leg syndrome)?
Summary: Restless legs syndrome is found among people who take Metformin, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take medication Metformin hcl, and have Diabetes.
We study 97,464 people who have side effects while taking Metformin from FDA and social media. Among them, 169 have Restless legs syndrome. Find out below who they are, when they have Restless legs syndrome and more.
You are not alone: join a mobile support group for people who take Metformin and have Restless legs syndrome >>>
Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from 101,000 Metformin users)
Restless legs syndrome
Restless legs syndrome (a powerful urge to move your legs) has been reported by people with restless leg syndrome, osteoporosis, depression, pain, high blood pressure. (latest reports from 17,478 Restless legs syndrome patients)
On Feb, 25, 2015: 97,464 people reported to have side effects when taking Metformin. Among them, 169 people (0.17%) have Restless Legs Syndrome.
Time on Metformin when people have Restless legs syndrome * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Restless legs syndrome||0.00%||8.33%||16.67%||25.00%||8.33%||33.33%||8.33% |
Gender of people who have Restless legs syndrome when taking Metformin * :
|Restless legs syndrome||54.39%||45.61% |
Age of people who have Restless legs syndrome when taking Metformin * :
|Restless legs syndrome||0.00%||0.00%||0.00%||0.71%||10.00%||15.00%||29.29%||45.00% |
Severity of Restless legs syndrome when taking Metformin ** :
|least||moderate||severe||most severe |
|Restless legs syndrome||8.33%||33.33%||41.67%||16.67% |
How people recovered from Restless legs syndrome ** :
|while on the drug||after off the drug||not yet |
|Restless legs syndrome||0.00%||75.00%||25.00% |
Top conditions involved for these people * :
- Diabetes mellitus (30 people, 17.75%)
- Restless legs syndrome (30 people, 17.75%)
- Gastrooesophageal reflux disease (20 people, 11.83%)
- Depression (19 people, 11.24%)
- Hypertension (19 people, 11.24%)
Top co-used drugs for these people * :
- Metformin hcl (97 people, 57.40%)
- Aspirin (58 people, 34.32%)
- Lisinopril (50 people, 29.59%)
- Lipitor (41 people, 24.26%)
- Requip (34 people, 20.12%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Get connected: join our support group of metformin and restless legs syndrome on
Do you have Restless Legs Syndrome while taking Metformin?
You are not alone! Join a mobile support group:
- support group for people who take Metformin and have Restless Legs Syndrome
- support group for people who take Metformin
- support group for people who have Restless Legs Syndrome
Drugs in real world that are associated with:
Could your condition cause:
Can you answer these questions (Ask a question):
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Comments from related studies:
From this study (13 months ago):
Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.
From this study (13 months ago):
Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.
From this study (2 years ago):
Paul on Nov, 9, 2012:
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