Review: could Methotrexate Sodium cause Constipation?


Constipation is found among people who take Methotrexate Sodium, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Folic Acid, and have Rheumatoid arthritis . We study 8,120 people who have side effects while taking Methotrexate sodium from FDA and social media. Among them, 47 have Constipation. Find out below who they are, when they have Constipation and more.

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Methotrexate Sodium

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate sodium 8,456 users)


Constipation has been reported by people with breathing difficulty, fever, weakness, diarrhea, pneumonia (latest reports from 95,174 Constipation patients).

On Aug, 24, 2016

8,120 people reported to have side effects when taking Methotrexate Sodium.
Among them, 47 people (0.58%) have Constipation

Number of reports submitted per year:

Could Methotrexate sodium cause Constipation?

Time on Methotrexate Sodium when people have Constipation *:

  • < 1 month: 16.67 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 16.67 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 0.0 %

Gender of people who have Constipation when taking Methotrexate Sodium *:

  • female: 88.64 %
  • male: 11.36 %

Age of people who have Constipation when taking Methotrexate Sodium *:

  • 0-1: 0.0 %
  • 2-9: 2.94 %
  • 10-19: 2.94 %
  • 20-29: 0.0 %
  • 30-39: 2.94 %
  • 40-49: 20.59 %
  • 50-59: 35.29 %
  • 60+: 35.29 %

Severity if Constipation when taking Methotrexate Sodium **:

  • least: 0.0 %
  • moderate: 0.0 %
  • severe: 100 %
  • most severe: 0.0 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (22 people)
  • Osteoporosis (11 people)
  • Pain (7 people)
  • Pain Management (6 people)
  • Blood Thyroid Stimulating Hormone Decreased (6 people)

Top co-used drugs for these people *:

  • Folic Acid (18 people)
  • Prednisone (17 people)
  • Remicade (16 people)
  • Fosamax (11 people)
  • Humira (10 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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