Review: could Methotrexate Sodium cause Deafness?


Deafness is found among people who take Methotrexate Sodium, especially for people who are female, 50-59 old , have been taking the drug for 2 - 5 years, also take medication Humira, and have Rheumatoid arthritis . We study 8,120 people who have side effects while taking Methotrexate sodium from FDA and social media. Among them, 13 have Deafness. Find out below who they are, when they have Deafness and more.

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Methotrexate Sodium

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate sodium 8,682 users)


Deafness has been reported by people with breathing difficulty, rashes, tinnitus, hiccups, paraesthesia (latest reports from 9,329 Deafness patients).

On Aug, 28, 2016

8,120 people reported to have side effects when taking Methotrexate Sodium.
Among them, 13 people (0.16%) have Deafness

Number of reports submitted per year:

Could Methotrexate sodium cause Deafness?

Time on Methotrexate Sodium when people have Deafness *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Deafness when taking Methotrexate Sodium *:

  • female: 92.31 %
  • male: 7.69 %

Age of people who have Deafness when taking Methotrexate Sodium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 40 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 40 %
  • 60+: 20 %

Severity if Deafness when taking Methotrexate Sodium **:

  • least: 0.0 %
  • moderate: 100 %
  • severe: 0.0 %
  • most severe: 0.0 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (8 people)
  • Psoriatic Arthropathy (1 person)
  • Pain (1 person)
  • Ill-Defined Disorder (1 person)
  • Breast Cancer (1 person)

Top co-used drugs for these people *:

  • Humira (6 people)
  • Prednisolone (4 people)
  • Enbrel (3 people)
  • Folic Acid (2 people)
  • Carboplatin (2 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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