Review: could Methotrexate Sodium cause Dementia?


Dementia is found among people who take Methotrexate Sodium, especially for people who are female, 60+ old also take medication Enbrel, and have Rheumatoid arthritis . We study 8,267 people who have side effects while taking Methotrexate sodium from FDA and social media. Among them, 16 have Dementia. Find out below who they are, when they have Dementia and more.

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Methotrexate Sodium

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate sodium 13,109 users)


Dementia (madness) has been reported by people with osteoporosis, high blood pressure, multiple sclerosis, depression, rheumatoid arthritis (latest reports from 18,299 Dementia patients).

On Oct, 08, 2016

8,267 people reported to have side effects when taking Methotrexate Sodium.
Among them, 16 people (0.19%) have Dementia

Number of reports submitted per year:

Could Methotrexate sodium cause Dementia?

Gender of people who have Dementia when taking Methotrexate Sodium *:

  • female: 56.25 %
  • male: 43.75 %

Age of people who have Dementia when taking Methotrexate Sodium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 16.67 %
  • 60+: 83.33 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (14 people, 87.50%)
  • Burkitt's Lymphoma (2 people, 12.50%)
  • Hyperlipidaemia (1 person, 6.25%)
  • Depression (1 person, 6.25%)
  • Aggression (1 person, 6.25%)

Top co-used drugs for these people *:

  • Enbrel (8 people, 50.00%)
  • Prednisone Tab (7 people, 43.75%)
  • Leucovorin Calcium (7 people, 43.75%)
  • Celebrex (7 people, 43.75%)
  • Actonel (7 people, 43.75%)

Top other side effects for these people *:

  • Weight Decreased (12 people, 75.00%)
  • Schizophrenia (8 people, 50.00%)
  • Persecutory Delusion (7 people, 43.75%)
  • Hallucination, Auditory (7 people, 43.75%)
  • Tuberculosis (4 people, 25.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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