Review: could Methotrexate Sodium cause Insomnia?


Insomnia is found among people who take Methotrexate Sodium, especially for people who are female, 50-59 old , have been taking the drug for 1 - 6 months, also take medication Folic Acid, and have Rheumatoid arthritis . We study 8,120 people who have side effects while taking Methotrexate sodium from FDA and social media. Among them, 74 have Insomnia. Find out below who they are, when they have Insomnia and more.

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Methotrexate Sodium

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate sodium 8,456 users)


Insomnia (sleeplessness) has been reported by people with drug ineffective, drowsiness, memory loss, fatigue, stress and anxiety (latest reports from 141,076 Insomnia patients).

On Aug, 23, 2016

8,120 people reported to have side effects when taking Methotrexate Sodium.
Among them, 74 people (0.91%) have Insomnia

Number of reports submitted per year:

Could Methotrexate sodium cause Insomnia?

Time on Methotrexate Sodium when people have Insomnia *:

  • < 1 month: 16.67 %
  • 1 - 6 months: 25.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 16.67 %
  • 2 - 5 years: 16.67 %
  • 5 - 10 years: 8.33 %
  • 10+ years: 16.67 %

Gender of people who have Insomnia when taking Methotrexate Sodium *:

  • female: 73.61 %
  • male: 26.39 %

Age of people who have Insomnia when taking Methotrexate Sodium *:

  • 0-1: 0.0 %
  • 2-9: 1.69 %
  • 10-19: 1.69 %
  • 20-29: 5.08 %
  • 30-39: 6.78 %
  • 40-49: 30.51 %
  • 50-59: 33.9 %
  • 60+: 20.34 %

Severity if Insomnia when taking Methotrexate Sodium **:

  • least: 0.0 %
  • moderate: 33.33 %
  • severe: 66.67 %
  • most severe: 0.0 %

How people recovered from Insomnia **:

  • while on drug: 0.0 %
  • after off the drug: 0.0 %
  • not yet: 100 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (47 people)
  • Depression (10 people)
  • Pain (9 people)
  • Osteoporosis (9 people)
  • Vitamin B Complex Deficiency (6 people)

Top co-used drugs for these people *:

  • Folic Acid (29 people)
  • Enbrel (21 people)
  • Prednisone (19 people)
  • Remicade (16 people)
  • Humira (15 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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