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Review: could Methotrexate sodium cause Constipation?

Summary: Constipation is found among people who take Methotrexate sodium, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Prednisone, and have Rheumatoid arthritis.

We study 7,195 people who have side effects while taking Methotrexate sodium from FDA and social media. Among them, 44 have Constipation. Find out below who they are, when they have Constipation and more.

You are not alone: join a mobile support group for people who take Methotrexate sodium and have Constipation >>>

 

 

 

 

Methotrexate sodium

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 7,840 Methotrexate sodium users)

Constipation

Constipation has been reported by people with osteoporosis, pain, high blood pressure, depression, high blood cholesterol. (latest reports from 81,342 Constipation patients)

On Jan, 4, 2015: 7,195 people reported to have side effects when taking Methotrexate sodium. Among them, 44 people (0.61%) have Constipation.

Trend of Constipation in Methotrexate sodium reports

Time on Methotrexate sodium when people have Constipation * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Constipation0.00%33.33%0.00%33.33%0.00%33.33%0.00%

Age of people who have Constipation when taking Methotrexate sodium * :

0-12-910-1920-2930-3940-4950-5960+
Constipation0.00%2.86%0.00%0.00%2.86%17.14%48.57%28.57%

Severity of Constipation when taking Methotrexate sodium ** :

leastmoderateseveremost severe
Constipation0.00%0.00%100.00%0.00%

How people recovered from Constipation ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (25 people, 56.82%)
  2. Osteoporosis (17 people, 38.64%)
  3. Pain (17 people, 38.64%)
  4. Vitamin b complex deficiency (12 people, 27.27%)
  5. Blood thyroid stimulating hormone decreased (12 people, 27.27%)

Top co-used drugs for these people * :

  1. Prednisone (25 people, 56.82%)
  2. Remicade (21 people, 47.73%)
  3. Folic acid (18 people, 40.91%)
  4. Fosamax (17 people, 38.64%)
  5. Levothyroxine sodium (16 people, 36.36%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Constipation while taking Methotrexate Sodium?

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- support group for people who take Methotrexate sodium and have Constipation
- support group for people who take Methotrexate sodium
- support group for people who have Constipation

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More questions for: Methotrexate sodium, Constipation

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    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

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    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • I need advise, badly ckd!! (1 response)
    The orthostatic BP started in mid April, I was only dizzy upon wakening then it would subside. I have never been a big breakfast eater so I started doing that. We were in Disney later in April and I was extremely fatigued, to the point of not wanting to walk, Disney would be the first time I passed out when getting dizzy. I of course said I had gotten too warm and was exhausted from work the previous week. The dizziness continued in the mornings & I passed out several more times. On May 1st, I passed out while putting my make-up on and hit my eye on the faucet and head on the tile floor, despite that I went to work thinking it would subside, it didn't. I went to the ER directly after work. They ran a B-met on me and my GFR was 11 and creatinine 3.95. They admitted me to a larger hospital for evaluation. While in there, they pumped me with fluids continuously, saying I had severe dehydration. My kidney function improved, my creatinine levels went back down to 1.34. After 5 days I was discharged and told to see a cardiologist and endo. The endo doc cancelled my appointment on the basis it was not his area. I had had a cortisol and ACTH testing which I guess was normal. I saw the cardiologist, who said it wasn't cardio. I had had an echocardiogram in the hospital and EKG monitoring. Cardio sent me to neurology, the PNRN did a basic neurological exam and drew blood for disease markers such as Lupus, sjorgens, hepatitis, ect. All disease markers came back negative, but my GFR was at 11 again and creatinine was 4.25, BUN 50 along with an elevated ACE level. They called me and said I sarcoidosis. I really don't have any of the primary S/S of this autoimmune disease. I don't know where to go from here, they are referring me to another neurologist at a bigger hospital. I can't live my normal life, can't walk on my feet due extreme pain and I pass out at least 2x a week, which is not good for my old body. My BP upon laying and sitting runs like 117/72, upon standing it drops to like 70/50-50/30. I am on 0.1 mg of florinef, I tried increasing it but then my legs swelled up for a gain of 23#. I talked to Mayo Clinic today and all there specialists are booked out thru December. I have to be able to work, I can't stay home any longer than September 8th! Please advise me!

More reviews for: Methotrexate sodium, Constipation

Comments from related studies:

  • From this study (6 months ago):

  • Extensive Travel

    Reply

  • From this study (10 months ago):

  • I just begsn tx for rs using safest meds possible but did not yolerste pills so we are doing injections once a week but since we started I developed abdom ook nal edema plus whole body especially feet which subsided ptior to msjor orgsn testing hestt kidney bloodwotk a nd liver ultra sound. Results were normsl all in but kidney workup. We are trying to get to third week of methotrexate tx becausr the last uri which my ra dr treated immediately with snyibiotics my ra pain seemed much better I just had abdominal swelling and pressure on lungs thrn and yhis time entire body swelled dr rulled out ra it was edrma order err d tests with bed rest feet up over weekend causing edema to go away prior to echo and ultra sound. Tests were normal so went to pulmonologist to get help breathing and they were sfraid to use antibiotics just like my primary dr brgore they know nothing about my ra drugs so how am I supposed to stop this from going inyo pneumonia?

    Reply

  • From this study (1 year ago):

  • I suffer from UC for 8 years, the past 2 years I have had many flare ups, so I am almost Steroid dependent, as they are the only thing that works. So to get off Steroids, i have tried Azathiopran (didn't work caused severe side-effects) then 6MP, (also failed due to lowering my WBC and caused me to become Neurtaphinic and i caught C-Diff), so I am now trying Methotrexate, but I got a blood clot on the lung (4 weeks ago). After I came out of hospital for a week, I was given Warfarin tablets (3 weeks ago) and ever since I've taken them, I have not passed ANY stools naturally. I went 8 days with no movement, so ended up using Microlex Enema to release some, which works, but I have been using them every day for the past 13 days as its the only thing that gets me 'going', only only some soft stools slide out (look normal and soft), so am I constipated or do I have a blockage, or are these drugs stopping me from having the "urge" to go. My belly is ever so bloated, tight and aches a little.
    I am only 10.5 stone and 36 years old, I have a swollen face too....
    I've only taken 3 doeses (one a week) of Methotrexate, so I think it is too early for any side affects of this drug to kick in yet (I began the Warfarin on the Friday and the Methotrexate on the Monday (3 weeks ago)...
    Help please?.... as all the consultants and doctors say is "Try enemas and water etc bla bla...." but I am now dependent on the Microlex enema to go...

    Reply

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