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Review: could Methotrexate sodium cause Fluid retention?





Summary: Fluid retention is found among people who take Methotrexate sodium, especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Rheumatoid arthritis.

We study 7,195 people who have side effects while taking Methotrexate sodium from FDA and social media. Among them, 11 have Fluid retention. Find out below who they are, when they have Fluid retention and more.

You are not alone: join a mobile support group for people who take Methotrexate sodium and have Fluid retention >>>

Methotrexate sodium

Methotrexate Sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate Sodium 7,840 users)

Fluid retention

Fluid retention (an abnormal accumulation of fluid in the blood) has been reported by people with high blood pressure, primary pulmonary hypertension, diabetes, type 2 diabetes, osteoporosis.(latest reports from Fluid retention 17,802 patients)

On Nov, 30, 2014: 7,195 people reported to have side effects when taking Methotrexate sodium. Among them, 11 people (0.15%) have Fluid Retention.

Trend of Fluid retention in Methotrexate sodium reports

Time on Methotrexate sodium when people have Fluid retention * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Fluid retention0.00%80.00%0.00%0.00%0.00%20.00%0.00%

Age of people who have Fluid retention when taking Methotrexate sodium * :

0-12-910-1920-2930-3940-4950-5960+
Fluid retention0.00%0.00%0.00%27.27%9.09%18.18%18.18%27.27%

Severity of Fluid retention when taking Methotrexate sodium ** :

leastmoderateseveremost severe
Fluid retention0.00%100.00%0.00%0.00%

How people recovered from Fluid retention ** :

while on the drugafter off the drugnot yet
Fluid retention0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (7 people, 63.64%)
  2. Lymphocytic leukaemia (3 people, 27.27%)
  3. Clostridium difficile colitis (3 people, 27.27%)
  4. Psoriasis (2 people, 18.18%)

Top co-used drugs for these people * :

  1. Enbrel (6 people, 54.55%)
  2. Cyclophosphamide (4 people, 36.36%)
  3. Prednisone (4 people, 36.36%)
  4. Folic acid (4 people, 36.36%)
  5. Dasatinib (3 people, 27.27%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Fluid Retention while taking Methotrexate Sodium?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate sodium and have Fluid Retention
- support group for people who take Methotrexate sodium
- support group for people who have Fluid Retention

Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

  • Hlab27 antigen and unexplained scratches caused by accutane
    (Asked by a 49 year old woman who has Scratches, Swelling, Burning, Nerve, Muscle Pain, Conjunctivitis, and takes Methotrexate)
    Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) unexplained scratches in same location, forearms, lower thigh (by knee) fingers. Scratches always are in a line with a break in the line. When a woman hits menopause hormones cease and when this happens the path that Accutane takes to cease sebaceous gland function, skin proliferation ceases. Therefore, my friends the HLA B27 (abnormal antigen targeted for skin proliferation does not know where to go so it randomly attacks whatever organ it chooses. Accutane if I remember correctly and I do have proof, permanently alters DNA. There is no other way orally ingesting a retinolic acid it could control skin, hormonal cesessation. I have only been diagnosed thus far with psoriatic arthritis with no other explanations for these other symptoms. I wonder why this is and I also wonder why dermatologists refuse to take a biopsy of my skin to rule out cell skin proliferation dysfunction. What will this damaging drug attack next. Do no be fooled by Dr.s who tell you that you took this drug so long ago how could this be. Well folks, it is because it has already changed your DNA to the HLAB27 antigen. My question also is, what was supposed to be where this abnormal DNA antigen is and how come this antigen only shows up at menopause. My disease (autoimmune) is progressive) and has already attacked nervous, muscle, skin, joints etc. Interesting
    Reply
  • Has anybody had multi lobar pneumonia from reaction to methotrexate?
    (Asked by a 57 year old woman who has Migraine Without Aura, Anxiety And Stress, Major Depression With Psychotic Features, Bilateral Multilobar Pneumonia, Ankylosing Spondylitis, and takes Zyprexa, Methotrexate)
    Bilateral multilobar pneumonia - rheumatologist considers it was caused by a reaction to methotrexate I was taking for ankylosing spondylitis and I was lucky to survive. Anyone have this and later shown to have scarring of the lungs?
    Reply
  • I am a 56 year old female with rheumatoid arthritis. i also have found out i have osteoporosis. i keep getting right breast sensitivity also tingling and tenderness in right scapula area... (2 answers)
    (Asked by a 56 year old woman who has Hign Blood Pressure, Osteoporosis Postmenopausal, Rheumatoid Arthritis, and takes Methotrexate)
    I am a 56 year old female with tingling in my right shoulder blade and some tenderness. I have occasional breast discomfort in the same side and sometimes my rt. nipple feels sensitive. If I touch the area, the symptom on the nipple vanishes. at times the tingling travels into my neck and symptoms seem more noticeable in the evening. If I shower in a warm shower the symptoms will vanish for a time.. All my mammograms have been normal and never miss any but it has me very worried. I check my breasts often for lumps. From time to time it also seems like I have tenderness along the sternum on that side. I have rhematoid arthritis as well as was recently told I have osteoporosis. I had a thoracic x-ray and they can see loss of bone density and some vertebrae degeneration. Take methotrexate each week and folic acid every day....Any ideas out there???? Thanks
    Reply
  • Can i take marijuana while taking gilenya
    (Asked by a 36 year old woman who has MS, and takes Gilenya)
    Hello i would like to know if is safe to have marijuane with gilenya and methotraxate
    Reply
  • Do i need to temporarily stop taking my enbrel and methotrexate (that i take every week) while i am on azithromycin for severe cold symptoms? (1 answer)
    (Asked by a 47 year old woman who has Rheumatoid Arthritis, and takes Dexamethasone, Tussicaps, Azithromycin, Methotrexate, Enbrel)
    i have RA and take Enbrel and methotrexate every week. i am currently taking azithromycin, tussicaps and dexamethasone to treat a severe cold, cough, sore throat, etc. My question is should i stop taking the ra meds until my antibiotics and steroids are done? Or should i just continue as normal, don't want to get sicker than i already am!!!! thanks
    Reply

More questions for: Methotrexate sodium, Fluid retention

You may be interested at these reviews (Write a review):

  • Humira: my experience
    (Posted by a 66 year old man who has Ankylosing Spondylitis, Reiter's Syndrome, Psoriatic Arthritis, and takes Methotrexate Preservative Free, Enbrel, Humira)
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Pantopraz sod 40mg,retaining alot of fluids
    (Posted by a 46 year old man who has Water Retention, and takes Pantoprazole)
    I am retaining a lot of fluids from my hips and down to my feet and believe its from taking pantoprazole,and I mean everything,its scary,has anyone been down this road?
  • Psoratic arthritis and trigeminal neuralgia
    (Posted by a 33 year old man who has Nasal Septum Deviation, Psoriasis, Psoriatic Arthritis, Trigeminal Neuralgia, Asthma Exercise Induced, and takes Methotrexate)
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    (Posted by a 46 year old woman who has Rheumatoid Arthritis, Irritable Bowel Syndrome, and takes Advair Diskus 250/50, Methotrexate, Plaquenil, Metformin, Klonopin, Zanaflex, Prednisone, Singulair, Imitrex, Nexium)
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Personalized review of arava (1 response)
    (Posted by a 65 year old woman who has Rheumatoid Arthritis, and takes Methotrexate)
    Have had RA for 10 years and was on Methotrexate those 10 years. Had nose bleeds which got progressively worse over the years and began to effect my quality of living. Doctor said it could NOT be the drug, but according to eHealth Me, it could. At urging of an ENT, I stopped taking Methotrexate and the nose bleeds have now almost completely stopped. My doctor put me on Arava 3 days ago and I am on eHealth to study the effects of it.

More reviews for: Methotrexate sodium, Fluid retention

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