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Review: could Methotrexate sodium cause Fluid retention?

Summary: Fluid retention is found among people who take Methotrexate sodium, especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Rheumatoid arthritis.

We study 7,195 people who have side effects while taking Methotrexate sodium from FDA and social media. Among them, 11 have Fluid retention. Find out below who they are, when they have Fluid retention and more.

You are not alone: join a mobile support group for people who take Methotrexate sodium and have Fluid retention >>>

 

 

 

 

Methotrexate sodium

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 7,840 Methotrexate sodium users)

Fluid retention

Fluid retention (an abnormal accumulation of fluid in the blood) has been reported by people with primary pulmonary hypertension, high blood pressure, diabetes, type 2 diabetes, osteoporosis. (latest reports from 18,400 Fluid retention patients)

On Jan, 4, 2015: 7,195 people reported to have side effects when taking Methotrexate sodium. Among them, 11 people (0.15%) have Fluid Retention.

Trend of Fluid retention in Methotrexate sodium reports

Time on Methotrexate sodium when people have Fluid retention * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Fluid retention0.00%80.00%0.00%0.00%0.00%20.00%0.00%

Age of people who have Fluid retention when taking Methotrexate sodium * :

0-12-910-1920-2930-3940-4950-5960+
Fluid retention0.00%0.00%0.00%27.27%9.09%18.18%18.18%27.27%

Severity of Fluid retention when taking Methotrexate sodium ** :

leastmoderateseveremost severe
Fluid retention0.00%100.00%0.00%0.00%

How people recovered from Fluid retention ** :

while on the drugafter off the drugnot yet
Fluid retention0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (7 people, 63.64%)
  2. Lymphocytic leukaemia (3 people, 27.27%)
  3. Clostridium difficile colitis (3 people, 27.27%)
  4. Psoriasis (2 people, 18.18%)

Top co-used drugs for these people * :

  1. Enbrel (6 people, 54.55%)
  2. Cyclophosphamide (4 people, 36.36%)
  3. Prednisone (4 people, 36.36%)
  4. Folic acid (4 people, 36.36%)
  5. Dasatinib (3 people, 27.27%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Fluid Retention while taking Methotrexate Sodium?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate sodium and have Fluid Retention
- support group for people who take Methotrexate sodium
- support group for people who have Fluid Retention

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More questions for: Methotrexate sodium, Fluid retention

You may be interested at these reviews (Write a review):

  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Pantopraz sod 40mg,retaining alot of fluids
    I am retaining a lot of fluids from my hips and down to my feet and believe its from taking pantoprazole,and I mean everything,its scary,has anyone been down this road?
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Personalized review of arava (1 response)
    Have had RA for 10 years and was on Methotrexate those 10 years. Had nose bleeds which got progressively worse over the years and began to effect my quality of living. Doctor said it could NOT be the drug, but according to eHealth Me, it could. At urging of an ENT, I stopped taking Methotrexate and the nose bleeds have now almost completely stopped. My doctor put me on Arava 3 days ago and I am on eHealth to study the effects of it.

More reviews for: Methotrexate sodium, Fluid retention

Comments from related studies:

  • From this study (10 months ago):

  • My diafram. Feels like its pushing on my lungs but they are clear to doctors check up.

    Diagnosed with fatty liver disease during this time due to bloodwork and echo on heart then abdominal ultrasound

    Does ra attack liver or is it causing infect ion on an organ white blood cell couny in all three labs were very high as well as sugar levels being slighty high

    Reply

  • From this study (10 months ago):

  • I just begsn tx for rs using safest meds possible but did not yolerste pills so we are doing injections once a week but since we started I developed abdom ook nal edema plus whole body especially feet which subsided ptior to msjor orgsn testing hestt kidney bloodwotk a nd liver ultra sound. Results were normsl all in but kidney workup. We are trying to get to third week of methotrexate tx becausr the last uri which my ra dr treated immediately with snyibiotics my ra pain seemed much better I just had abdominal swelling and pressure on lungs thrn and yhis time entire body swelled dr rulled out ra it was edrma order err d tests with bed rest feet up over weekend causing edema to go away prior to echo and ultra sound. Tests were normal so went to pulmonologist to get help breathing and they were sfraid to use antibiotics just like my primary dr brgore they know nothing about my ra drugs so how am I supposed to stop this from going inyo pneumonia?

    Reply

  • From this study (2 years ago):

  • Had first Rituxan infusion yesterday

    Reply

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