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Review: could Methotrexate cause Fluid retention?

Summary: Fluid retention could be caused by Methotrexate, especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months, also take Enbrel, and have Rheumatoid arthritis.

We study 7,072 people who have side effects while taking Methotrexate from FDA and social media. Among them, 11 have Fluid retention. Find out below who they are, when they have Fluid retention and more.

On Apr, 8, 2014: 7,071 people reported to have side effects when taking Methotrexate sodium. Among them, 11 people (0.16%) have Fluid Retention. They amount to 0.01% of all the 88,768 people who have Fluid Retention on eHealthMe.

Trend of Fluid retention in Methotrexate sodium reports

Time on Methotrexate sodium when people have Fluid retention * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Fluid retention0.00%80.00%0.00%0.00%0.00%20.00%0.00%

Age of people who have Fluid retention when taking Methotrexate sodium * :

0-12-910-1920-2930-3940-4950-5960+
Fluid retention0.00%0.00%0.00%27.27%9.09%18.18%18.18%27.27%

Severity of Fluid retention when taking Methotrexate sodium ** :

leastmoderateseveremost severe
Fluid retention0.00%100.00%0.00%0.00%

How people recovered from Fluid retention ** :

while on the drugafter off the drugnot yet
Fluid retention0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (7 people, 63.64%)
  2. Clostridium difficile colitis (3 people, 27.27%)
  3. Lymphocytic leukaemia (3 people, 27.27%)
  4. Psoriasis (2 people, 18.18%)

Top co-used drugs for these people * :

  1. Enbrel (6 people, 54.55%)
  2. Cyclophosphamide (4 people, 36.36%)
  3. Prednisone (4 people, 36.36%)
  4. Folic acid (4 people, 36.36%)
  5. Etoposide (3 people, 27.27%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methotrexate sodium, Fluid retention

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On eHealthMe, Methotrexate Sodium (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate Sodium is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate Sodium used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (3 weeks ago):

  • My diafram. Feels like its pushing on my lungs but they are clear to doctors check up.

    Diagnosed with fatty liver disease during this time due to bloodwork and echo on heart then abdominal ultrasound

    Does ra attack liver or is it causing infect ion on an organ white blood cell couny in all three labs were very high as well as sugar levels being slighty high

    Reply

  • From this study (3 weeks ago):

  • I just begsn tx for rs using safest meds possible but did not yolerste pills so we are doing injections once a week but since we started I developed abdom ook nal edema plus whole body especially feet which subsided ptior to msjor orgsn testing hestt kidney bloodwotk a nd liver ultra sound. Results were normsl all in but kidney workup. We are trying to get to third week of methotrexate tx becausr the last uri which my ra dr treated immediately with snyibiotics my ra pain seemed much better I just had abdominal swelling and pressure on lungs thrn and yhis time entire body swelled dr rulled out ra it was edrma order err d tests with bed rest feet up over weekend causing edema to go away prior to echo and ultra sound. Tests were normal so went to pulmonologist to get help breathing and they were sfraid to use antibiotics just like my primary dr brgore they know nothing about my ra drugs so how am I supposed to stop this from going inyo pneumonia?

    Reply

  • From this study (1 year ago):

  • Had first Rituxan infusion yesterday

    Reply

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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