Review: could Methotrexate cause Insomnia?
Summary: Insomnia could be caused by Methotrexate, especially for people who are female, 40-49 old, also take Folic acid, and have Rheumatoid arthritis.
We study 7,072 people who have side effects while taking Methotrexate from FDA and social media. Among them, 54 have Insomnia. Find out below who they are, when they have Insomnia and more.
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Methotrexate sodium (latest outcomes from 7,837 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.
Insomnia (sleeplessness) (latest reports from 776,701 patients) has been reported by people with depression, quit smoking, high blood pressure, pain, pain relief by acupuncture.
On Apr, 10, 2014: 7,072 people reported to have side effects when taking Methotrexate sodium. Among them, 59 people (0.83%) have Insomnia. They amount to 0.01% of all the 781,791 people who have Insomnia on eHealthMe.
Time on Methotrexate sodium when people have Insomnia * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
Age of people who have Insomnia when taking Methotrexate sodium * :
Severity of Insomnia when taking Methotrexate sodium ** :
|least||moderate||severe||most severe |
How people recovered from Insomnia ** :
|while on the drug||after off the drug||not yet |
Top conditions involved for these people * :
- Rheumatoid arthritis (57 people, 96.61%)
- Pain (16 people, 27.12%)
- Osteoporosis (16 people, 27.12%)
- Pain management (12 people, 20.34%)
- Blood thyroid stimulating hormone decreased (12 people, 20.34%)
Top co-used drugs for these people * :
- Folic acid (26 people, 44.07%)
- Enbrel (25 people, 42.37%)
- Remicade (21 people, 35.59%)
- Prednisone (19 people, 32.20%)
- Fosamax (18 people, 30.51%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Related topic: Methotrexate sodium, Insomnia
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On eHealthMe, Methotrexate Sodium (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate Sodium is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.
What is Methotrexate Sodium used for and how effective is it:
Other drugs that are used to treat the same conditions:
Could it be a symptom from a condition:
Drugs in real world that are associated with:
Could your condition cause it?
Comments from related studies:
From this study (8 months ago):
Sleep Apnea - treated with Cpap.
From this study (1 year ago):
Thrash around (awake, needing to move, repetition song or poem in head, no worries) in bed until about 6:00a.m. Then sleep about 3-4 hours. Exhausted. Losing weight. Don't take naps. Methotrexate at 10mg, folic acid at 1mg per day. Recently reduced folic acid to 5mcg daily, in hopes of improvement. This unrelenting cycle started when pharmacy switched my Advair for cheaper Dulera. After 2 months of about 3 hours of morning sleep only and 6 pounds lost, back to Advair. But imsomnia pattern continues, though with very slow weight gain (good, for me). Age 65. Only a 12.5mg CR Ambien works--so take it about 2X month. 5mg Ambien (generic) does not work. Afraid of taking Ambien often. Wonder if a sensitivity to the folic acid might be the likely culprit.
From this study (1 year ago):
Worse under personal stress conditions
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