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Review: could Methotrexate cause Anger?

Summary: Anger is found among people who take Methotrexate, especially for people who are male, 40-49 old, have been taking the drug for 1 - 6 months, also take medication Prednisone, and have Rheumatoid arthritis.

We study 129,897 people who have side effects while taking Methotrexate from FDA and social media. Among them, 52 have Anger. Find out below who they are, when they have Anger and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Anger >>>






Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)


Anger has been reported by people with depression, quit smoking, stress and anxiety, attention deficit hyperactivity disorder, pain. (latest reports from 14,902 Anger patients)

On Feb, 13, 2015: 129,882 people reported to have side effects when taking Methotrexate. Among them, 52 people (0.04%) have Anger.

Trend of Anger in Methotrexate reports

Time on Methotrexate when people have Anger * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Anger when taking Methotrexate * :


Age of people who have Anger when taking Methotrexate * :


Severity of Anger when taking Methotrexate ** :

leastmoderateseveremost severe

How people recovered from Anger ** :

while on the drugafter off the drugnot yet

Top conditions involved for these people * :

  1. Rheumatoid arthritis (17 people, 32.69%)
  2. Osteoporosis (6 people, 11.54%)
  3. Pain (6 people, 11.54%)
  4. Eczema (6 people, 11.54%)
  5. Fibromyalgia (3 people, 5.77%)

Top co-used drugs for these people * :

  1. Prednisone (26 people, 50.00%)
  2. Folic acid (23 people, 44.23%)
  3. Humira (14 people, 26.92%)
  4. Oxycontin (14 people, 26.92%)
  5. Prozac (13 people, 25.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of methotrexate and anger on

Do you have Anger while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Anger
- support group for people who take Methotrexate
- support group for people who have Anger

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Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.
  • Is it safe to take zocalo if you are taking humora and methotrexate
    Is it safe to take all three of these together? I need to know if there is any adverse side effects of taking these drugs at the same time?

More questions for: Methotrexate, Anger

You may be interested at these reviews (Write a review):

  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Personalized review of arava (1 response)
    Have had RA for 10 years and was on Methotrexate those 10 years. Had nose bleeds which got progressively worse over the years and began to effect my quality of living. Doctor said it could NOT be the drug, but according to eHealth Me, it could. At urging of an ENT, I stopped taking Methotrexate and the nose bleeds have now almost completely stopped. My doctor put me on Arava 3 days ago and I am on eHealth to study the effects of it.

More reviews for: Methotrexate, Anger

Comments from related studies:

  • From this study (5 days ago):

  • cheryl on Jan, 31, 2015:

    My husband is 44years old and has been on antianxiety pills for 4 years and antidepressants for 3years. His whole personality changed not long after starting all those years ago. He was never diagnosed with either anxiety or depression but put on them by a GP for one panic attack. He is addicted after so many years and GPs just hand him scripts one after the other with out any questions. He tells them nothing about his compulsive gambling, compulsive lies, anger, lack of feelings or emotions about anything including me. He has no impulse control and seems to not care about anything he does at all. This is the complete opposite of who he used to be. He did taper off once recently and I helped him to do it very slowly. He started to become a bit more normal during the taper but got sick only two days off them altogether and panicked and I think he has gone back on them behind my back. His behavior has gone back to how it used to be and he is lying, gambling ignoring me for weeks if I question him and just being a horrible person to me. He has done some very low things over the years but his most recent one is telling me that I can't say that he has done bad things because I was apparently a whore before he met me. That is so far from the truth that people are shocked and disgusted that he could even suggest it. Well so am I and I have had enough. I have stayed for all these years thinking I could help him to get off those poison pills and he could return to the person he used to be. I couldn't believe it myself that this could happen to a man who loved me more than anything just by taking a pill prescribed by a doctor. I have done a lot of research over the last 2 years and have found a lot of evidence to support that it can happen especially if you didn't really need them in the first place and then stay on them long term. The sad thing is that the person on them doesn't see who and what they became. In their warped and medicated mind they think everyone else is crazy. I had a small glimpse of my my old husband for a few months of tapering and during that time he did love me and talk to me and even wanted to buy me new rings for our anniversary in March this year. Now I am nothing again not worth talking to he just wants to sit in front of the tv after work and play poker all night. I am disgusted with the medical field and wish they knew how it felt to have your marriage and life ruined by a little pill. I have been put through hell and I still feel sorry for the man I lost to antidepressants. He is gone now.


    Chase on Sep, 2, 2012:

    First a little back ground about me, 46 long term stay at home father. Been described by others as the most calm and patient person that ever lived. Never I repeat never had any issues with raising the kids or dealing with my spouse indiscretions. I was on Pristiq for about 45 days after my doctor asked me to try this after being served with divorce papers. One of my children decides to make an issue of going to school and not giving me my property back to me. Normally I would have not raised my voice or lose my cool with the boy of 14 or result in physically removing the property from him. I noted several times before this episode it was becoming harder and harder to remain calm.
    After the episode I went to another MD and he removed me from this medication, with taper off routine, (this MD indicated that it is a side effect of the medication and had been reported). I must say I have not fully regained controlling myself anger wise since, though it is manageable with great effort. I would recommend never, ever using this medication and rather appalled my doctor succumbed to the dish out samples like candy routine, needless to say I will not be using her or any of her affiliates ever again.
    Please if you find anyway to remove the lasting effects of this medication, please, please post it.


    DJ on May, 28, 2011:

    I have been taking 50mg of Pristiq for about 16 days, since my spouse had an affair, and we are trying to work through it. He also prescribed me 0.5 of Larazepam for if I feel like I'm going to flip out.
    My comment is, I have at times have spells where I have had so much anger and disregard of what I say or text to my wife about what happened. I have had good days, and when I flip out, I can't stop myself from saying the worst things that I can think of.
    I am a very calm person, and this is definitely NOT me.
    One night, I wanted to take a hammer to my own windshield of my truck (it has a crack in it from a rock) but I never did it. I could visualize myself doing it on my way home from an event I was the DJ for, and after texting my wife rude things, I said I was leaving when I got home. I never did, but I've said some very mean things.

    I am also waking up at about 3:30am which is 1.5 hours before my work alarm, and I take my Pristiq at about 8 pm at night.
    I spoke with my PCP and he told me to stop taking it, and he will give me something else when I come in when they open.
    At this point, my wife is tired of being my verbal punching bag, and I have apologized for what I've said, but I keep doing it on a 2 times a week basis. Usually when she works her night shift, and I have time to have anxiety about things.
    I can't lose my family to this.


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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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