Review: could Methotrexate cause Application Site Pruritus?


Application site pruritus is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 10+ years, also take medication Humira, and have Rheumatoid arthritis . We study 197,009 people who have side effects while taking Methotrexate from FDA and social media. Among them, 34 have Application site pruritus. Find out below who they are, when they have Application site pruritus and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,463 users)

Application Site Pruritus

Application site pruritus (application site severe itching of the skin) has been reported by people with pain, quit smoking, attention deficit hyperactivity disorder, high blood pressure, actinic keratosis (latest reports from 10,964 Application site pruritus patients).

On Oct, 22, 2016

197,009 people reported to have side effects when taking Methotrexate.
Among them, 34 people (0.02%) have Application Site Pruritus

Number of reports submitted per year:

Could Methotrexate cause Application site pruritus?

Time on Methotrexate when people have Application Site Pruritus *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 100 %

Gender of people who have Application Site Pruritus when taking Methotrexate *:

  • female: 87.88 %
  • male: 12.12 %

Age of people who have Application Site Pruritus when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 3.57 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 7.14 %
  • 40-49: 32.14 %
  • 50-59: 25.0 %
  • 60+: 32.14 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (22 people, 64.71%)
  • Ovarian Cyst (6 people, 17.65%)
  • Pain (5 people, 14.71%)
  • Hypertension (3 people, 8.82%)
  • Arthritis (3 people, 8.82%)

Top co-used drugs for these people *:

  • Prednisone (10 people, 29.41%)
  • Humira (10 people, 29.41%)
  • Enbrel (8 people, 23.53%)
  • Folic Acid (6 people, 17.65%)
  • Omeprazole (4 people, 11.76%)

Top other side effects for these people *:

  • Application Site Erythema (22 people, 64.71%)
  • Application Site Pain (11 people, 32.35%)
  • Rheumatoid Arthritis (10 people, 29.41%)
  • Application Site Swelling (9 people, 26.47%)
  • Pain In Extremity (8 people, 23.53%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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