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Review: could Methotrexate cause Application site pruritus?

We study 129,821 people who have side effects while taking Methotrexate from FDA and social media. Among them, 23 have Application site pruritus. Find out below who they are, when they have Application site pruritus and more.

Get connected: join a mobile support group for people who take Methotrexate and have Application site pruritus >>>


Methotrexate (latest outcomes from 131,137 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Application site pruritus

Application site pruritus (application site severe itching of the skin) (latest reports from 15,743 patients) has been reported by people with high blood pressure, pain, attention deficit hyperactivity disorder, hormone replacement therapy, back pain.

On Sep, 23, 2014: 129,775 people reported to have side effects when taking Methotrexate. Among them, 23 people (0.02%) have Application Site Pruritus.

Trend of Application site pruritus in Methotrexate reports

Time on Methotrexate when people have Application site pruritus * :


Gender of people who have Application site pruritus when taking Methotrexate * :

Application site pruritus86.36%13.64%

Age of people who have Application site pruritus when taking Methotrexate * :

Application site pruritus0.00%0.00%0.00%0.00%5.56%33.33%33.33%27.78%

Severity of Application site pruritus when taking Methotrexate ** :


How people recovered from Application site pruritus ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (15 people, 65.22%)
  2. Ovarian cyst (6 people, 26.09%)
  3. Pain (3 people, 13.04%)
  4. Hypertension (3 people, 13.04%)
  5. Blood pressure (2 people, 8.70%)

Top co-used drugs for these people * :

  1. Humira (10 people, 43.48%)
  2. Prednisone (8 people, 34.78%)
  3. Folic acid (5 people, 21.74%)
  4. Enbrel (4 people, 17.39%)
  5. Duragesic-100 (3 people, 13.04%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Application Site Pruritus while taking Methotrexate?

Comments from related studies:

  • From this study (2 days ago):

  • I need to know if by taking cyclobenzaprine I may be causing my clarithomycin to stop working on my sinusitis.


  • From this study (5 days ago):

  • i'm a doctor. a patiente of mine ( a 3 yrs old boy with leukemia ) complains about leg cramps every time he takes methotrexate . I've never read anything about that .


  • From this study (7 days ago):

  • Wondering if sinusitis is a side effect of methotrexate?


    Altmed on Sep, 16, 2014:

    I've wondered if respiratory problems while taking Plaquenil is from parasites (non-malarial) are being chased into other tissues?

    Sweet wormwood seems to work better than Plaquanil for some.

    It would be interesting to see a study of those using wormwood instead of Plaquanil for RA.

    Interesting that becoming I'll elsewhere (lungs, feet pain/discoloration, hands/wrists) seems to increase in some after taking Plaquanil for a few weeks to months after starting even relatively "low doses".


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More reviews for: Methotrexate, Application site pruritus

On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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