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Review: could Methotrexate cause Application site pruritus?

Summary: Application site pruritus is found among people who take Methotrexate, especially for people who are female, 40-49 old, also take medication Humira, and have Rheumatoid arthritis.

We study 129,897 people who have side effects while taking Methotrexate from FDA and social media. Among them, 23 have Application site pruritus. Find out below who they are, when they have Application site pruritus and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Application site pruritus >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,236 Methotrexate users)

Application site pruritus

Application site pruritus (application site severe itching of the skin) has been reported by people with high blood pressure, pain, attention deficit hyperactivity disorder, hormone replacement therapy, back pain. (latest reports from 4,435 Application site pruritus patients)

On Jan, 29, 2015: 129,882 people reported to have side effects when taking Methotrexate. Among them, 23 people (0.02%) have Application Site Pruritus.

Trend of Application site pruritus in Methotrexate reports

Time on Methotrexate when people have Application site pruritus * :

n/a

Gender of people who have Application site pruritus when taking Methotrexate * :

FemaleMale
Application site pruritus86.36%13.64%

Age of people who have Application site pruritus when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Application site pruritus0.00%0.00%0.00%0.00%5.56%33.33%33.33%27.78%

Severity of Application site pruritus when taking Methotrexate ** :

n/a

How people recovered from Application site pruritus ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (15 people, 65.22%)
  2. Ovarian cyst (6 people, 26.09%)
  3. Pain (3 people, 13.04%)
  4. Hypertension (3 people, 13.04%)
  5. Arthralgia (2 people, 8.70%)

Top co-used drugs for these people * :

  1. Humira (10 people, 43.48%)
  2. Prednisone (8 people, 34.78%)
  3. Folic acid (5 people, 21.74%)
  4. Enbrel (4 people, 17.39%)
  5. Duragesic-100 (3 people, 13.04%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Application Site Pruritus while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Application Site Pruritus
- support group for people who take Methotrexate
- support group for people who have Application Site Pruritus

Recent conversations of related support groups:

Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.
  • Is it safe to take zocalo if you are taking humora and methotrexate
    Is it safe to take all three of these together? I need to know if there is any adverse side effects of taking these drugs at the same time?

More questions for: Methotrexate, Application site pruritus

You may be interested at these reviews (Write a review):

  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Personalized review of arava (1 response)
    Have had RA for 10 years and was on Methotrexate those 10 years. Had nose bleeds which got progressively worse over the years and began to effect my quality of living. Doctor said it could NOT be the drug, but according to eHealth Me, it could. At urging of an ENT, I stopped taking Methotrexate and the nose bleeds have now almost completely stopped. My doctor put me on Arava 3 days ago and I am on eHealth to study the effects of it.

More reviews for: Methotrexate, Application site pruritus

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  • I CONTINUE TO HAVE STARING SEIZURES,WITH HEAT,ANXIETY,PAIN,STRESS,FATIGUE,MUSCLE WEAKNESS,RESTLESS LEGS AND ARMS, TIA STROKES, NAUSEA, ETC...

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  • My jaw cracks,pops,grinds when I try to move it. Cant open hardly at all and pain is radiating throw my ear and temple.

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