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Review: could Methotrexate cause Back pain?

Summary: Back pain is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Folic acid, and have Rheumatoid arthritis.

We study 129,897 people who have side effects while taking Methotrexate from FDA and social media. Among them, 2,084 have Back pain. Find out below who they are, when they have Back pain and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Back pain >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)

Back pain

Back pain has been reported by people with osteoporosis, multiple sclerosis, pain, high blood pressure, rheumatoid arthritis. (latest reports from 107,077 Back pain patients)

On Feb, 25, 2015: 129,897 people reported to have side effects when taking Methotrexate. Among them, 2,084 people (1.60%) have Back Pain.

Trend of Back pain in Methotrexate reports

Time on Methotrexate when people have Back pain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Back pain26.11%20.38%14.65%16.56%5.10%10.19%7.01%

Gender of people who have Back pain when taking Methotrexate * :

FemaleMale
Back pain77.34%22.66%

Age of people who have Back pain when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Back pain0.06%2.00%3.67%2.84%7.07%18.26%22.88%43.21%

Severity of Back pain when taking Methotrexate ** :

leastmoderateseveremost severe
Back pain0.00%75.00%25.00%0.00%

How people recovered from Back pain ** :

while on the drugafter off the drugnot yet
Back pain0.00%25.00%75.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (1,098 people, 52.69%)
  2. Osteoporosis (217 people, 10.41%)
  3. Pain (184 people, 8.83%)
  4. Psoriatic arthropathy (122 people, 5.85%)
  5. Hypertension (115 people, 5.52%)

Top co-used drugs for these people * :

  1. Folic acid (746 people, 35.80%)
  2. Humira (620 people, 29.75%)
  3. Prednisone (511 people, 24.52%)
  4. Enbrel (509 people, 24.42%)
  5. Remicade (349 people, 16.75%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of methotrexate and back pain on

Do you have Back Pain while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Back Pain
- support group for people who take Methotrexate
- support group for people who have Back Pain

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Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

  • Can i use a lidocaine patch for back pain if i am taking prograf for anti-rejection post lung transplant?
    Transplant was 6 years ago.
    Has suffered from PTLD on several occasions before.
    Recently hospitalized for Periodic Fever Syndrome.
    Received Interleukin 6 blocker last week and fevers have resolved, but back pain is still present
  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Kindly tell me whether this treatment is accurate for spine tb?
    have spinal tb and having treatment since 5 months..also a kidney dialysis patient..having two dialysis per week...i think this treatment is not effective because i am having severe back pain, severe pain in feet..nausea..and shortness of breath...
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?

More questions for: Methotrexate, Back pain

You may be interested at these reviews (Write a review):

  • Naproxin reaction severe
    My partner was given Naproxin for back pain, after taking the reccommended dose of 2 per day for about 10 days he had a severe reaction. It started off with what looked like insect bites on his torso and arms, within half an hour, these had turned into huge welps that were blending together, He looked like he had been scalded all over. The itching was unbearable so rang NHS helpline, they said to get antihistimnes in the morning and to stop the Naproxin. My partner started to hallucinate, he said he saw vivid colours, a vortex of bright colours and flowers, then he passed out in the bathroom and it took a while to bring him round. He insisted he was fine and just wanted to sleep. In the morning we went to the GP, got some antihistimines but by now his whole body was in a mess, his hands had swollen to 3 x normal size and he was having cold sweats. By now the weekend was here so when he took another turn for the worse, we had to go to an out of hours gp, he saw the photos I had taken of the welps and immediately prescribed very strong antihistimines to be taken x 4 daily, thankfully after the second day everything normalised, we are in day 3 now and my hope is that when he stops taking the meds, the hives will not return. Very worrying medication in my opinion and one that I will not have in the house again.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Losartan cause deep vein thrombosis
    have had two knee surgeries ,a lumbar decompression, after this three surgeries start taken Losartan potassium and two months later have had a lumbar fusion after this I suffered a Deep Vein Thrombosis, continues taken Losartan for more of year and half, I notice is a bad combination when my older physician increase high dose of Warfarin I was losing mi Vision and stopped Losartan by my self and my vision is great now. my new physician told me that is OK that I had stopped taken Losartan. and I strongly believe that this cause me the DVT.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.

More reviews for: Methotrexate, Back pain

Comments from related studies:

  • From this study (6 days ago):

  • I had the flu for two weeks it has been gone two weeks but I stayed fatigued with dry cough. I had my infusion of Simponi Aria 10 days ago. My Methotrexate injection is due tomorrow.

    Reply

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