Review: could Methotrexate cause Bone Density Loss?


Bone density loss is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Folic Acid, and have Rheumatoid arthritis . We study 150,779 people who have side effects while taking Methotrexate from FDA and social media. Among them, 152 have Bone density loss. Find out below who they are, when they have Bone density loss and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 160,929 users)

Bone Density Loss

Bone density loss has been reported by people with weakness, back pain, drowsiness, hiatal hernia, head injury (latest reports from 7,430 Bone density loss patients).

On Aug, 29, 2016

150,779 people reported to have side effects when taking Methotrexate.
Among them, 152 people (0.1%) have Bone Density Loss

Number of reports submitted per year:

Could Methotrexate cause Bone density loss?

Time on Methotrexate when people have Bone Density Loss *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 15.38 %
  • 6 - 12 months: 23.08 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 38.46 %
  • 5 - 10 years: 23.08 %
  • 10+ years: 0.0 %

Gender of people who have Bone Density Loss when taking Methotrexate *:

  • female: 85.81 %
  • male: 14.19 %

Age of people who have Bone Density Loss when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 3.1 %
  • 10-19: 3.1 %
  • 20-29: 0.0 %
  • 30-39: 8.53 %
  • 40-49: 2.33 %
  • 50-59: 31.78 %
  • 60+: 51.16 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (74 people)
  • Osteoporosis (38 people)
  • Breast Cancer Metastatic (33 people)
  • Breast Cancer (29 people)
  • Prophylaxis (26 people)

Top co-used drugs for these people *:

  • Folic Acid (53 people)
  • Zometa (49 people)
  • Aredia (48 people)
  • Prednisone (46 people)
  • Fosamax (41 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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