Methotrexate and Bone density loss - from FDA reports


Summary

Bone density loss is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Folic Acid, and have Rheumatoid arthritis. This review analyzes which people have Bone density loss with Methotrexate. It is created by eHealthMe based on reports of 223,372 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

What to expect?

If you take Methotrexate and have Bone density loss, find out what symptoms you could have in 1 year or longer.

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On May, 11, 2017

223,372 people reported to have side effects when taking Methotrexate.
Among them, 218 people (0.1%) have Bone Density Loss


Number of reports submitted per year:

Could Methotrexate cause Bone density loss?

Time on Methotrexate when people have Bone Density Loss *:

  • < 1 month: 5.88 %
  • 1 - 6 months: 11.76 %
  • 6 - 12 months: 17.65 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 35.29 %
  • 5 - 10 years: 29.41 %
  • 10+ years: 0.0 %

Gender of people who have Bone Density Loss when taking Methotrexate *:

  • female: 85.17 %
  • male: 14.83 %

Age of people who have Bone Density Loss when taking Methotrexate *:

  • 0-1: 2.73 %
  • 2-9: 7.65 %
  • 10-19: 7.1 %
  • 20-29: 0.55 %
  • 30-39: 6.56 %
  • 40-49: 3.28 %
  • 50-59: 28.42 %
  • 60+: 43.72 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (108 people, 49.54%)
  • Osteoporosis (42 people, 19.27%)
  • Breast Cancer Metastatic (33 people, 15.14%)
  • Breast Cancer (29 people, 13.30%)
  • Preventive Health Care (28 people, 12.84%)

Top co-used drugs for these people *:

  • Folic Acid (58 people, 26.61%)
  • Prednisone (52 people, 23.85%)
  • Zometa (50 people, 22.94%)
  • Aredia (49 people, 22.48%)
  • Fosamax (42 people, 19.27%)

Top other side effects for these people *:

  • Nausea (74 people, 33.94%)
  • Diarrhea (70 people, 32.11%)
  • Nausea And Vomiting (66 people, 30.28%)
  • Joint Pain (55 people, 25.23%)
  • Osteoarthritis (53 people, 24.31%)

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Bone density loss when taking Methotrexate?

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 226,881 users)

Bone Density Loss

Bone density loss has been reported by people with osteoporosis, osteopenia, gastroesophageal reflux disease, high blood pressure, depression (latest reports from 10,169 Bone density loss patients).

Browse all side effects of Methotrexate

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Drugs that are associated with Bone density loss

Bone density loss

Could your condition cause Bone density loss

Bone density loss

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What would happen?

Forecast new side effects and undetected conditions when you take Methotrexate and have Bone density loss.

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