Review: could Methotrexate cause Bone density loss?
Summary: Bone density loss could be caused by Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take Folic acid, and have Rheumatoid arthritis.
We study 129,658 people who have side effects while taking Methotrexate from FDA and social media. Among them, 135 have Bone density loss. Find out below who they are, when they have Bone density loss and more.
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Methotrexate (latest outcomes from 130,985 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis, psoriatic arthritis. Commonly reported side effects of Methotrexate include fever, injection site pain, joint pain, rheumatoid arthritis aggravated, nausea.
Bone density loss
Bone density loss (latest reports from 45,507 patients) has been reported by people with osteoporosis, osteopenia, depression, breast cancer, high blood pressure.
On Apr, 13, 2014: 129,658 people reported to have side effects when taking Methotrexate. Among them, 135 people (0.10%) have Bone Density Loss. They amount to 0.30% of all the 45,467 people who have Bone Density Loss on eHealthMe.
Time on Methotrexate when people have Bone density loss * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Bone density loss||0.00%||9.09%||27.27%||0.00%||45.45%||18.18%||0.00% |
Gender of people who have Bone density loss when taking Methotrexate * :
|Bone density loss||89.13%||10.87% |
Age of people who have Bone density loss when taking Methotrexate * :
|Bone density loss||0.00%||3.20%||1.60%||0.00%||13.60%||1.60%||33.60%||46.40% |
Severity of Bone density loss when taking Methotrexate ** :
How people recovered from Bone density loss ** :
Top conditions involved for these people * :
- Rheumatoid arthritis (65 people, 48.15%)
- Osteoporosis (40 people, 29.63%)
- Breast cancer metastatic (32 people, 23.70%)
- Breast cancer (25 people, 18.52%)
- Prophylaxis (24 people, 17.78%)
Top co-used drugs for these people * :
- Folic acid (49 people, 36.30%)
- Zometa (47 people, 34.81%)
- Aredia (47 people, 34.81%)
- Fosamax (45 people, 33.33%)
- Prednisone (45 people, 33.33%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
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Related topic: Methotrexate, Bone density loss
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On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.
What is Methotrexate used for and how effective is it:
Other drugs that are used to treat the same conditions:
Could it be a symptom from a condition:
Drugs in real world that are associated with:
Could your condition cause it?
Comments from related studies:
From this study (2 days ago):
Trying to determine if the timing of these drugs- especially the weekly mtx- should be staggered during the day to ensure they are appropriately absorbed. Periodic seizures continue- about once a quarter.
From this study (4 days ago):
I never had any symptoms of raynauds until is was put on methotrexate,and then Enbrel,and now Humira.I used a automotive laser thermometer to check my arm
temp. which was 97 degrees,however my fingers on the same arm were between
From this study (5 days ago):
Dosage for methotrexate is 15 to 17 mg. over ten year period.
Have been taking about 800 mg. of frolic acid per day, plus whatever occurs naturally in food.
For about a year have been dealing with urinary retention. Don't know if there is a connection.
Will be seeing my doctor tomorrow .
Also take generic Zantac
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