Review: could Methotrexate cause Coughing (Cough)?
Summary: Coughing is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Humira, and have Rheumatoid arthritis.
We study 129,882 people who have side effects while taking Methotrexate from FDA and social media. Among them, 3,112 have Coughing. Find out below who they are, when they have Coughing and more.
You are not alone: join a mobile support group for people who take Methotrexate and have Coughing >>>
Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,224 Methotrexate users)
Coughing has been reported by people with rheumatoid arthritis, high blood pressure, asthma, osteoporosis, high blood cholesterol. (latest reports from 75,448 Coughing patients)
On Jan, 25, 2015: 129,882 people reported to have side effects when taking Methotrexate. Among them, 3,112 people (2.40%) have Coughing.
Time on Methotrexate when people have Coughing * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
Gender of people who have Coughing when taking Methotrexate * :
Age of people who have Coughing when taking Methotrexate * :
Severity of Coughing when taking Methotrexate ** :
|least||moderate||severe||most severe |
How people recovered from Coughing ** :
|while on the drug||after off the drug||not yet |
Top conditions involved for these people * :
- Rheumatoid arthritis (1,837 people, 59.03%)
- Pain (192 people, 6.17%)
- Hypertension (160 people, 5.14%)
- Psoriatic arthropathy (159 people, 5.11%)
- Vitamin supplementation (152 people, 4.88%)
Top co-used drugs for these people * :
- Humira (1,079 people, 34.67%)
- Enbrel (1,062 people, 34.13%)
- Folic acid (1,041 people, 33.45%)
- Prednisone (669 people, 21.50%)
- Remicade (387 people, 12.44%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Do you have Coughing while taking Methotrexate?
You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Coughing
- support group for people who take Methotrexate
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You may be interested at these reviews (Write a review):
- Faslodex driven hell
I have metastatic breast cancer...which has spread to my bones. Needless to say...I'm not a happy camper. Faslodex was my oncologist’s drug of choice for me. I've been on it since July 28, 2014....My first month was loading dosage...and each month that has followed I receive two injections in my tush...250mg each...for a total of 500mg monthly. Tomorrow, Monday November 17, 2014, will be my third round...not including the month of loading. As per my PET scan one month ago...the Faslodex has not started working. From everything I have been told...and read...it takes four to even six rounds to start working...if in fact it works at all.....@%^&*@#...says it all...if ya know what I mean.
What has kicked in from Faslodex...are some horrific side effects......About a month ago...I started having a strange little cough...dry...most of the time.....At times the cough becomes uncontrollable for aprox 15 / 20 minutes...then calms. NOTHING works at relieving it...although I suck down water like it is my last drink on earth...and use a wonderful...soothing throat drop, Halls Breezers...Cool Berry...which eases me...even if it is only psychologically, it is magical. The cough has gotten considerably worse over time...and for those that don't know me...I am sure they think I smoke ten packs a day. My voice is also affected at times due to the cough. My breathing is horrific...and I can no longer walk for any length of time...or for more than a short distance.....Nor can I walk and talk without coughing...and or losing my breath. Stamina...this I have none of!!! And this past week...the shit hit the fan.....Joining the cough...are bone and joint pains...as well as muscle pain. When I called my doctor...@ Sloan Kettering...I spoke with the nurse...and she had not a damn clue as to what might help. As a matter of fact...she told me that she has never heard of any of the side effects that I am now having. WHAT'S WRONG WITH THIS PICTURE???? EVERYTHING!!! However...when I check reputable sites...I find not a few...but hundreds of other people with the same side effects.
From what I have read on all the sites...the only way "WE" are going to get help with issues like these...is by sharing with one another. Not one of the individuals that I speak of has had any positive help with their side effects from their doctors. Am I pissed off??? You bet I am. As for depression...that only comes in small doses for me.....like yesterday...when my body hurt me so badly...my cough was out of control...I had difficulty breathing...and I could not stand on my own two feet without holding on. That moment in time has passed...but for how long??? What will I be hit with next??? When???
- Humira: my experience
I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.
I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(
I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.
I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.
My MD is going to get me onto another injectable that I take monthly. I forget its name.
- Levaquin and confusion symptoms
Confusion. Stopped dosage at day 6 of 7; prescribed 500 mg. 1 daily. I thought the confusion was from the weeks of pretty severe coughing symptoms, associated with the sinusitus - thought maybe from a lack of oxygen from not being able to breathe well for so long. I finally stopped the med. when "dementia-type" symptoms were apparent, night following dose #6, I was having difficulty determining which (of 2) pieces of hardware at our master bathroom sink, was the soap and which was the water (have lived here 15 years). I had been having many occurences of confusion for the majority of the 6 days on Levaquin and had been saying I was often feeling "so confused" for several days but none so apparent as this was. I am a long time mental health counselor and realized this was what I understand dementia symptoms resemble, stopped the med. Had M.D. appt. next day, he agreed stop good idea, put me on prednisone. Did research this morning before beginning prednisone & am not going to take it, due to reading it may increase negative side effects of the Levaquin. I am also e-mailing your website info. to my M.D. as I am also treated for depression and anxiety symptoms and fear symptoms will worsen. This is day 2 off the med., no improvement in confusion symptoms YET, I am hopeful that people wrote in soon after their negative experiences and that the confusion symptoms will resolve (soon.)
- Psoratic arthritis and trigeminal neuralgia
hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
- Spiriva caused me to swell up like a hippo.
My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
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Sarcoidosis caused complete heart block. Pacemaker implanted in December 2009 but for the past two years I have had palpitations caused by around 3.7 million ectopic heartbeats per year.
Sarcoidosis also in lungs and eyes. Extended use of Pred Forte caused development of cataracts, one of which has been removed and I am awaiting the second operation.
Breathlessness is caused by lack of oxygen entering the bloodstream and my ongoing heart problems
Rarely able to sleep properly due to pain, sleeping for about 20 minutes at a time when I become so exhausted that the pain can't keep me awake
Muscle and joint pain have made me weak and clumsy.Pain is felt all over, from head to toes along with muscle cramps and intense burning sensation to skin on lower legs.
ACE levels fluctuate but average 110 - 150.
Blood pressure on average is 150 / 78 - no treatment given
I also take Nefopam Hydrochloride (Acupan) for pain but this drug is not on the list.
Immobility, fatigue and constant pain have left me very depressed ad harbouring thoughts of suicide. My 15 year old granddaughter has lived with me since the death of my daughter 11 years ago and it is my hope that I will live long enough to see her settled in college and independent after which the only thing I have to look forward to is to end my own suffering.
IchikireiLV on Sep, 5, 2014:
I was so sorry to read your comment, but glad I encountered it. PLEASE PLEASE don't ever think of taking your own life! I know what it is like to suffer. I injured myself 7 yrs ago, got a spinal implant that failed, compressed my spine, corroded and left me with heavy metal toxicity which caused adrenal failure, hypothyroid and many other serious health conditions. I have lived a life of chronic pain, fatigue and difficulty, so I know exactly where you are coming from! Some days I am so weak and have so much pain that I cannot get out of bed or care for myself. At times I try to puch myself to do the simplest things and my body is so frail I can barely catch my breath and feel like I gave to crawl back to my bed, dripping in sweat, dehydrated and defeated... but I still go on in hopes that there will be a better day. I ENCOURAGE YOU TO SEE A PAIN MANAGEMENT DR. MONTHLY FOR MEDICATIONS TO CONTROL YOUR PAIN! This alone will improve your daily life immensely! Pain will make you depressed! I also use Savella. It helps with Neuropathy pain AND DEPRESSION. Dont give up because doctors arent helping you enough. MAKE THEM! Its unacceptable that they are not following thru but I myself have experienced this many times.. Find another better, more compassionate Dr. Read Dr. reviews online, start with a primary care family dr, a pain dr and a rhuematologist for Sarcoidosis... make sure the Dr. is experienced with Sarcoidosis.. if not, find another one. I hope this helps you and gives you a direction to follow. Once your pain is controlled, things will be a lot better. Good luck and wishes of health and most of all HOPE and HAPPINESS 😄😄
Kath Nugent on Aug, 26, 2014:
I was diagnosed with Lymphatic Sarcoidosis 15 years ago. After massive weight loss, a node in my neck the size of a small egg, and at the same time an
area of my gum opened up were i had a tooth removed 20 years earlier, Sarcoid grew out of this opening !!it was like a piece of green string. My GP & Consultant tried to pull it out but failed,it was about an inch long. i was sent away with no further appointment, So i went to see my Dentist who seemed to know what it was and sent me to the Hospital Dentist who did a jaw bone Scraping and arranged for the node in neck to be removed for biopsy, both biopsy came back as Sarcoidosis. i was then x rayed and was found to have it in on my lungs as well. at this point i had active Sarcoidosis in my Lymphatic system, bone, lungs. However it as never been active in my lungs !!! it did however eat away the inside of my nose, it attacked my eyes i almost went blind, i lost my balance,it was in my brain.
i was so tired, and after so many steroids i was having a bad reaction to them in various organs and was taken of them. i did recover from this as the Sarcoid went dormant. i have recently been diagnosed with a brain tumor and raised platelets. given that Sarcoidosis is next door to Cancer and that i feel absolutely wasted and week!!! i am feeling anxious about the outcome of more tests. But we all have to go sometime and i know there are people out there worse than me !!! i send you all love & light and hope we can all have the strength to help each other through whatever is thrown at us!! not easy by any means. Happy to answer any questions if it will help anyone Take care Kath Nugent
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