Review: could Methotrexate cause Diarrhoea?


Summary

Diarrhoea is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Humira, and have Rheumatoid arthritis . We study 191,458 people who have side effects while taking Methotrexate from FDA and social media. Among them, 5,238 have Diarrhoea. Find out below who they are, when they have Diarrhoea and more.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

Diarrhoea

Diarrhoea has been reported by people with fever, rashes, constipation, drug ineffective, weakness (latest reports from 253,439 Diarrhoea patients).

On Sep, 16, 2016

191,458 people reported to have side effects when taking Methotrexate.
Among them, 5,238 people (2.74%) have Diarrhoea


Number of reports submitted per year:

Could Methotrexate cause Diarrhoea?

Time on Methotrexate when people have Diarrhoea *:

  • < 1 month: 43.88 %
  • 1 - 6 months: 18.53 %
  • 6 - 12 months: 7.37 %
  • 1 - 2 years: 7.73 %
  • 2 - 5 years: 11.69 %
  • 5 - 10 years: 7.01 %
  • 10+ years: 3.78 %

Gender of people who have Diarrhoea when taking Methotrexate *:

  • female: 72.6 %
  • male: 27.4 %

Age of people who have Diarrhoea when taking Methotrexate *:

  • 0-1: 1.28 %
  • 2-9: 4.5 %
  • 10-19: 6.41 %
  • 20-29: 4.21 %
  • 30-39: 7.18 %
  • 40-49: 14.55 %
  • 50-59: 26.15 %
  • 60+: 35.73 %

Severity if Diarrhoea when taking Methotrexate **:

  • least: 0.0 %
  • moderate: 69.23 %
  • severe: 23.08 %
  • most severe: 7.69 %

How people recovered from Diarrhoea **:

  • while on drug: 7.69 %
  • after off the drug: 7.69 %
  • not yet: 84.62 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (2,423 people, 46.26%)
  • Psoriatic Arthropathy (393 people, 7.50%)
  • Hypertension (347 people, 6.62%)
  • Pain (306 people, 5.84%)
  • Crohn's Disease (300 people, 5.73%)

Top co-used drugs for these people *:

  • Humira (1,207 people, 23.04%)
  • Folic Acid (1,107 people, 21.13%)
  • Enbrel (933 people, 17.81%)
  • Prednisone (740 people, 14.13%)
  • Folic Acid. (432 people, 8.25%)

Top other side effects for these people *:

  • Nausea (1,446 people, 27.61%)
  • Vomiting (1,414 people, 27.00%)
  • Pyrexia (882 people, 16.84%)
  • Abdominal Pain (805 people, 15.37%)
  • Fatigue (717 people, 13.69%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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