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Review: could Methotrexate cause Headache?

We study 129,746 people who have side effects while taking Methotrexate from FDA and social media. Among them, 3,822 have Headache. Find out below who they are, when they have Headache and more.

Stay connected: get help anytime and anywhere for people who take Methotrexate and have Headache >>>

Methotrexate

Methotrexate (latest outcomes from 131,079 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Headache

Headache (pain in head) (latest reports from 1,199,394 patients) has been reported by people with multiple sclerosis, high blood pressure, depression, rheumatoid arthritis, osteoporosis.

On Jul, 13, 2014: 129,735 people reported to have side effects when taking Methotrexate. Among them, 4,569 people (3.52%) have Headache. They amount to 0.38% of all the 1,190,183 people who have Headache on eHealthMe.

Trend of Headache in Methotrexate reports

Time on Methotrexate when people have Headache * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Headache32.15%17.04%12.86%8.04%8.68%12.54%8.68%

Gender of people who have Headache when taking Methotrexate * :

FemaleMale
Headache77.72%22.28%

Age of people who have Headache when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Headache0.00%3.54%7.19%5.43%10.10%18.37%27.53%27.84%

Severity of Headache when taking Methotrexate ** :

leastmoderateseveremost severe
Headache14.29%50.00%28.57%7.14%

How people recovered from Headache ** :

while on the drugafter off the drugnot yet
Headache7.69%0.00%92.31%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (2,418 people, 52.92%)
  2. Pain (299 people, 6.54%)
  3. Psoriatic arthropathy (257 people, 5.62%)
  4. Hypertension (185 people, 4.05%)
  5. Psoriasis (159 people, 3.48%)

Top co-used drugs for these people * :

  1. Enbrel (1,576 people, 34.49%)
  2. Folic acid (1,496 people, 32.74%)
  3. Humira (1,115 people, 24.40%)
  4. Prednisone (950 people, 20.79%)
  5. Remicade (603 people, 13.20%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

  • From this study (2 months ago):

  • The abnormal dreams & mild hallucinations came only after starting the methylprednisolone a few days ago. They happen primarily when I am sleeping. I woke up last night with very unusual dreams & head/brain pain, and was quite concerned. I had taken 1 methylprednisolone & 1 cymbalta before bed. Earlier in the day, I had taken 2 methylprednisolone & 2 tramadol before a nap, and had similar, though not as severe issues. Trying to figure out what the interaction problem is. I did not take the muscle relaxant (cyclopenzaprine) before bed since I started the cortico steroid pack.

    Reply

    britsarmymom on Apr, 26, 2014:

    Mother just survived near brush with respiratory arrest. Hallucinated at night on Tramadol, argumentative with RN who reported her to MD. He planned to ADD Seroquel 25 mg to Tramadol, Neurontin, Remeron and Ativan in rehab facility. She declined Tramadol and Seroquel and was still so sedated her pulse ox went down to 84 with long periods of apnea and need for constant obs with frequent rousing for airway. MAJOR struggle with RN to get 02 and MD agreed to no more Tramodol at night and absolutely no Seroquel. How many elderly are lost this way?

    Reply

  • From this study (3 months ago):

  • All lesions necrosis
    Painful granulomas
    I live in chronic pain and fatigue

    Reply

  • From this study (10 months ago):

  • The only time the pain is partially releaved is lying in a prone position with heat on my posterior neck and the back of my head. The pain strats in my shoulders and neck and radiates up the back of my head.

    Reply

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On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

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