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Review: could Methotrexate cause Headache?

Summary: Headache is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Enbrel, and have Rheumatoid arthritis.

We study 129,882 people who have side effects while taking Methotrexate from FDA and social media. Among them, 3,826 have Headache. Find out below who they are, when they have Headache and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Headache >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,233 Methotrexate users)

Headache

Headache (pain in head) has been reported by people with multiple sclerosis, depression, high blood pressure, rheumatoid arthritis, osteoporosis. (latest reports from 202,234 Headache patients)

On Jan, 13, 2015: 129,858 people reported to have side effects when taking Methotrexate. Among them, 4,573 people (3.52%) have Headache.

Trend of Headache in Methotrexate reports

Time on Methotrexate when people have Headache * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Headache31.75%16.83%13.02%8.57%8.57%12.38%8.89%

Gender of people who have Headache when taking Methotrexate * :

FemaleMale
Headache77.72%22.28%

Age of people who have Headache when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Headache0.00%3.54%7.21%5.43%10.12%18.37%27.52%27.81%

Severity of Headache when taking Methotrexate ** :

leastmoderateseveremost severe
Headache12.50%56.25%25.00%6.25%

How people recovered from Headache ** :

while on the drugafter off the drugnot yet
Headache6.25%0.00%93.75%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (2,420 people, 52.92%)
  2. Pain (299 people, 6.54%)
  3. Psoriatic arthropathy (257 people, 5.62%)
  4. Hypertension (185 people, 4.05%)
  5. Psoriasis (159 people, 3.48%)

Top co-used drugs for these people * :

  1. Enbrel (1,576 people, 34.46%)
  2. Folic acid (1,497 people, 32.74%)
  3. Humira (1,115 people, 24.38%)
  4. Prednisone (950 people, 20.77%)
  5. Remicade (603 people, 13.19%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Headache while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Headache
- support group for people who take Methotrexate
- support group for people who have Headache

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    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.

More reviews for: Methotrexate, Headache

Comments from related studies:

  • From this study (4 months ago):

  • All lesions necrosis
    Painful granulomas
    I live in chronic pain and fatigue

    Reply

    Lisa on Sep, 4, 2014:

    Female 55 I have bechets. Diagnosed at 39. I take every medication on that list except I dropped methotrexate. I worse since I dropped it. And I have every symptom including ganglion cyst which needs to be surgically removed to the throat lesion. I can barely function. The only 5hing I dont have is the allergic cough. I did have mrsa phenomia once. Oh most recently plursey. I have been ivig dependent for 13 years.

    Reply

  • From this study (6 months ago):

  • feeling flushed and nauseaous after taking dose of methotrexate. Slight headache and overall not feeling well with headache and fatigue.

    Reply

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