Review: could Methotrexate cause Hepatic Cirrhosis?


Hepatic cirrhosis is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 1 - 2 years, also take medication Humira, and have Rheumatoid arthritis . We study 150,779 people who have side effects while taking Methotrexate from FDA and social media. Among them, 237 have Hepatic cirrhosis. Find out below who they are, when they have Hepatic cirrhosis and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 160,929 users)

Hepatic Cirrhosis

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue) has been reported by people with blood bilirubin increased, acute kidney failure, liver disorder, diarrhea, pancytopenia (latest reports from 7,941 Hepatic cirrhosis patients).

On Aug, 28, 2016

150,779 people reported to have side effects when taking Methotrexate.
Among them, 237 people (0.16%) have Hepatic Cirrhosis

Number of reports submitted per year:

Could Methotrexate cause Hepatic cirrhosis?

Time on Methotrexate when people have Hepatic Cirrhosis *:

  • < 1 month: 6 %
  • 1 - 6 months: 14 %
  • 6 - 12 months: 18 %
  • 1 - 2 years: 20 %
  • 2 - 5 years: 12 %
  • 5 - 10 years: 14 %
  • 10+ years: 16 %

Gender of people who have Hepatic Cirrhosis when taking Methotrexate *:

  • female: 57.71 %
  • male: 42.29 %

Age of people who have Hepatic Cirrhosis when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 1.81 %
  • 10-19: 2.41 %
  • 20-29: 8.43 %
  • 30-39: 1.81 %
  • 40-49: 10.24 %
  • 50-59: 26.51 %
  • 60+: 48.8 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (111 people)
  • Psoriatic Arthropathy (26 people)
  • Psoriasis (24 people)
  • Hypertension (18 people)
  • Ankylosing Spondylitis (15 people)

Top co-used drugs for these people *:

  • Humira (75 people)
  • Folic Acid (42 people)
  • Remicade (32 people)
  • Enbrel (30 people)
  • Prednisolone (29 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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