Review: could Methotrexate cause Hepatic Cirrhosis?


Summary

Hepatic cirrhosis is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Humira, and have Rheumatoid arthritis . We study 168,042 people who have side effects while taking Methotrexate from FDA and social media. Among them, 278 have Hepatic cirrhosis. Find out below who they are, when they have Hepatic cirrhosis and more.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

Hepatic Cirrhosis

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue) has been reported by people with death, rashes, thrombocytopenia, weakness, ascites (latest reports from 11,025 Hepatic cirrhosis patients).

On Sep, 05, 2016

168,042 people reported to have side effects when taking Methotrexate.
Among them, 278 people (0.17%) have Hepatic Cirrhosis


Number of reports submitted per year:

Could Methotrexate cause Hepatic cirrhosis?

Time on Methotrexate when people have Hepatic Cirrhosis *:

  • < 1 month: 8.62 %
  • 1 - 6 months: 10.34 %
  • 6 - 12 months: 15.52 %
  • 1 - 2 years: 15.52 %
  • 2 - 5 years: 18.97 %
  • 5 - 10 years: 17.24 %
  • 10+ years: 13.79 %

Gender of people who have Hepatic Cirrhosis when taking Methotrexate *:

  • female: 58.49 %
  • male: 41.51 %

Age of people who have Hepatic Cirrhosis when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 1.52 %
  • 10-19: 2.03 %
  • 20-29: 7.61 %
  • 30-39: 2.54 %
  • 40-49: 9.64 %
  • 50-59: 28.43 %
  • 60+: 48.22 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (131 people, 47.12%)
  • Psoriasis (34 people, 12.23%)
  • Psoriatic Arthropathy (33 people, 11.87%)
  • Hypertension (21 people, 7.55%)
  • Ankylosing Spondylitis (15 people, 5.40%)

Top co-used drugs for these people *:

  • Humira (87 people, 31.29%)
  • Folic Acid (45 people, 16.19%)
  • Enbrel (44 people, 15.83%)
  • Remicade (36 people, 12.95%)
  • Prednisone (29 people, 10.43%)

Top other side effects for these people *:

  • Ascites (47 people, 16.91%)
  • Varices Oesophageal (30 people, 10.79%)
  • Portal Hypertension (28 people, 10.07%)
  • Hepatic Steatosis (28 people, 10.07%)
  • Hepatic Failure (27 people, 9.71%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Hepatic cirrhosis when taking Methotrexate?

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