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Review: could Methotrexate cause Hepatic cirrhosis?

Summary: Hepatic cirrhosis is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months, also take medication Humira, and have Rheumatoid arthritis.

We study 129,925 people who have side effects while taking Methotrexate from FDA and social media. Among them, 266 have Hepatic cirrhosis. Find out below who they are, when they have Hepatic cirrhosis and more.

You are not alone: join a support group for people who take Methotrexate and have Hepatic cirrhosis >>>



Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,267 Methotrexate users)

Hepatic cirrhosis

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue) has been reported by people with hepatitis c, hiv infection, high blood pressure, diabetes, rheumatoid arthritis. (latest reports from 8,925 Hepatic cirrhosis patients)

On Apr, 18, 2015: 129,925 people reported to have side effects when taking Methotrexate. Among them, 266 people (0.20%) have Hepatic Cirrhosis.

Trend of Hepatic cirrhosis in Methotrexate reports

Time on Methotrexate when people have Hepatic cirrhosis * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Hepatic cirrhosis11.11%19.75%20.99%13.58%17.28%8.64%8.64%

Gender of people who have Hepatic cirrhosis when taking Methotrexate * :

Hepatic cirrhosis57.59%42.41%

Age of people who have Hepatic cirrhosis when taking Methotrexate * :

Hepatic cirrhosis0.00%0.83%2.07%6.20%1.24%10.33%34.71%44.63%

Severity of Hepatic cirrhosis when taking Methotrexate ** :


How people recovered from Hepatic cirrhosis ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (126 people, 47.37%)
  2. Ankylosing spondylitis (28 people, 10.53%)
  3. Urticaria (26 people, 9.77%)
  4. Hypertension (23 people, 8.65%)
  5. Psoriatic arthropathy (19 people, 7.14%)

Top co-used drugs for these people * :

  1. Humira (91 people, 34.21%)
  2. Prednisolone (45 people, 16.92%)
  3. Folic acid (45 people, 16.92%)
  4. Prednisone (43 people, 16.17%)
  5. Remicade (41 people, 15.41%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Methotrexate and hepatic cirrhosis on

Do you have Hepatic Cirrhosis while taking Methotrexate?




You are not alone! Join a support group on :
- support group for people who take Methotrexate and have Hepatic Cirrhosis
- support group for people who take Methotrexate
- support group for people who have Hepatic Cirrhosis

Drugs in real world that are associated with:

Could your condition cause:

Recent related drug studies (Check your drugs):

Recent Methotrexate related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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