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Review: could Methotrexate cause Hepatic cirrhosis?

We study 129,821 people who have side effects while taking Methotrexate from FDA and social media. Among them, 266 have Hepatic cirrhosis. Find out below who they are, when they have Hepatic cirrhosis and more.

Get connected: join a mobile support group for people who take Methotrexate and have Hepatic cirrhosis >>>

Methotrexate

Methotrexate (latest outcomes from 131,137 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Hepatic cirrhosis

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue) (latest reports from 42,960 patients) has been reported by people with hepatitis c, hiv infection, high blood pressure, diabetes, depression.

On Sep, 18, 2014: 129,775 people reported to have side effects when taking Methotrexate. Among them, 266 people (0.20%) have Hepatic Cirrhosis.

Trend of Hepatic cirrhosis in Methotrexate reports

Time on Methotrexate when people have Hepatic cirrhosis * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Hepatic cirrhosis11.11%19.75%20.99%13.58%17.28%8.64%8.64%

Gender of people who have Hepatic cirrhosis when taking Methotrexate * :

FemaleMale
Hepatic cirrhosis57.59%42.41%

Age of people who have Hepatic cirrhosis when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Hepatic cirrhosis0.00%0.83%2.07%6.20%1.24%10.33%34.71%44.63%

Severity of Hepatic cirrhosis when taking Methotrexate ** :

n/a

How people recovered from Hepatic cirrhosis ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (126 people, 47.37%)
  2. Ankylosing spondylitis (28 people, 10.53%)
  3. Urticaria (26 people, 9.77%)
  4. Hypertension (23 people, 8.65%)
  5. Psoriatic arthropathy (19 people, 7.14%)

Top co-used drugs for these people * :

  1. Humira (91 people, 34.21%)
  2. Prednisolone (45 people, 16.92%)
  3. Folic acid (45 people, 16.92%)
  4. Prednisone (43 people, 16.17%)
  5. Remicade (41 people, 15.41%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Hepatic Cirrhosis while taking Methotrexate?

Get connected! Join a mobile support group:
- group for people who take Methotrexate and have Hepatic Cirrhosis
- group for people who take Methotrexate
- group for people who have Hepatic Cirrhosis

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  • From this study (1 week ago):

  • Sarcoidosis caused complete heart block. Pacemaker implanted in December 2009 but for the past two years I have had palpitations caused by around 3.7 million ectopic heartbeats per year.

    Sarcoidosis also in lungs and eyes. Extended use of Pred Forte caused development of cataracts, one of which has been removed and I am awaiting the second operation.

    Breathlessness is caused by lack of oxygen entering the bloodstream and my ongoing heart problems

    Rarely able to sleep properly due to pain, sleeping for about 20 minutes at a time when I become so exhausted that the pain can't keep me awake

    Muscle and joint pain have made me weak and clumsy.Pain is felt all over, from head to toes along with muscle cramps and intense burning sensation to skin on lower legs.

    ACE levels fluctuate but average 110 - 150.

    Blood pressure on average is 150 / 78 - no treatment given

    I also take Nefopam Hydrochloride (Acupan) for pain but this drug is not on the list.

    Immobility, fatigue and constant pain have left me very depressed ad harbouring thoughts of suicide. My 15 year old granddaughter has lived with me since the death of my daughter 11 years ago and it is my hope that I will live long enough to see her settled in college and independent after which the only thing I have to look forward to is to end my own suffering.

    Reply

    Kath Nugent on Aug, 26, 2014:

    I was diagnosed with Lymphatic Sarcoidosis 15 years ago. After massive weight loss, a node in my neck the size of a small egg, and at the same time an
    area of my gum opened up were i had a tooth removed 20 years earlier, Sarcoid grew out of this opening !!it was like a piece of green string. My GP & Consultant tried to pull it out but failed,it was about an inch long. i was sent away with no further appointment, So i went to see my Dentist who seemed to know what it was and sent me to the Hospital Dentist who did a jaw bone Scraping and arranged for the node in neck to be removed for biopsy, both biopsy came back as Sarcoidosis. i was then x rayed and was found to have it in on my lungs as well. at this point i had active Sarcoidosis in my Lymphatic system, bone, lungs. However it as never been active in my lungs !!! it did however eat away the inside of my nose, it attacked my eyes i almost went blind, i lost my balance,it was in my brain.
    i was so tired, and after so many steroids i was having a bad reaction to them in various organs and was taken of them. i did recover from this as the Sarcoid went dormant. i have recently been diagnosed with a brain tumor and raised platelets. given that Sarcoidosis is next door to Cancer and that i feel absolutely wasted and week!!! i am feeling anxious about the outcome of more tests. But we all have to go sometime and i know there are people out there worse than me !!! i send you all love & light and hope we can all have the strength to help each other through whatever is thrown at us!! not easy by any means. Happy to answer any questions if it will help anyone Take care Kath Nugent

    Reply

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On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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