Methotrexate and Hepatic cirrhosis - from FDA reports


Summary

Hepatic cirrhosis is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Humira, and have Psoriatic arthropathy. This review analyzes which people have Hepatic cirrhosis with Methotrexate. It is created by eHealthMe based on reports of 231,270 people who have side effects when taking Methotrexate from FDA , and is updated regularly.

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On Sep, 16, 2017

231,270 people reported to have side effects when taking Methotrexate.
Among them, 496 people (0.21%) have Hepatic cirrhosis


Number of reports submitted per year:

Could Methotrexate cause Hepatic cirrhosis?

Time on Methotrexate when people have Hepatic cirrhosis *:

  • < 1 month: 2.94 %
  • 1 - 6 months: 8.82 %
  • 6 - 12 months: 17.65 %
  • 1 - 2 years: 10.78 %
  • 2 - 5 years: 22.55 %
  • 5 - 10 years: 24.51 %
  • 10+ years: 12.75 %

Gender of people who have Hepatic cirrhosis when taking Methotrexate *:

  • female: 57.02 %
  • male: 42.98 %

Age of people who have Hepatic cirrhosis when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.85 %
  • 10-19: 1.41 %
  • 20-29: 5.92 %
  • 30-39: 2.82 %
  • 40-49: 11.27 %
  • 50-59: 29.86 %
  • 60+: 47.89 %

Top conditions involved for these people *:

  • Psoriatic Arthropathy (50 people, 10.08%)
  • High Blood Pressure (29 people, 5.85%)
  • Pain (18 people, 3.63%)
  • Diabetes (17 people, 3.43%)
  • Ankylosing Spondylitis (16 people, 3.23%)

Top co-used drugs for these people *:

  • Humira (140 people, 28.23%)
  • Enbrel (89 people, 17.94%)
  • Remicade (64 people, 12.90%)
  • Folic Acid (53 people, 10.69%)
  • Arava (45 people, 9.07%)

Top other side effects for these people *:

  • Ascites (72 people, 14.52%)
  • Thrombocytopenia (50 people, 10.08%)
  • Portal Hypertension (40 people, 8.06%)
  • Weakness (39 people, 7.86%)
  • Hepatic Failure (39 people, 7.86%)

* Approximation only. Some reports may have incomplete information.

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Hepatic cirrhosis and drugs with ingredients of methotrexate sodium.

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Hepatic cirrhosis and Methotrexate from FDA and eHealthMe reports

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 234,877 users)

Hepatic cirrhosis

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue) has been reported by people with hepatitis c, hiv infection, rheumatoid arthritis, high blood pressure, diabetes (latest reports from 13,295 Hepatic cirrhosis patients).

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