Review: could Methotrexate cause Influenza?


Influenza is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 1 - 2 years, also take medication Enbrel, and have Rheumatoid arthritis . We study 150,779 people who have side effects while taking Methotrexate from FDA and social media. Among them, 1,027 have Influenza. Find out below who they are, when they have Influenza and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 160,929 users)


Influenza has been reported by people with breathing difficulty, fever, agitation, drug exposure during pregnancy, hallucinations (latest reports from 31,210 Influenza patients).

On Aug, 28, 2016

150,779 people reported to have side effects when taking Methotrexate.
Among them, 1,027 people (0.68%) have Influenza

Number of reports submitted per year:

Could Methotrexate cause Influenza?

Time on Methotrexate when people have Influenza *:

  • < 1 month: 18 %
  • 1 - 6 months: 12 %
  • 6 - 12 months: 14 %
  • 1 - 2 years: 22 %
  • 2 - 5 years: 16 %
  • 5 - 10 years: 14 %
  • 10+ years: 4 %

Gender of people who have Influenza when taking Methotrexate *:

  • female: 81.02 %
  • male: 18.98 %

Age of people who have Influenza when taking Methotrexate *:

  • 0-1: 0.38 %
  • 2-9: 2.38 %
  • 10-19: 2.25 %
  • 20-29: 3.38 %
  • 30-39: 8.64 %
  • 40-49: 20.65 %
  • 50-59: 30.16 %
  • 60+: 32.17 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (640 people)
  • Pain (101 people)
  • Psoriatic Arthropathy (76 people)
  • Hypertension (70 people)
  • Depression (45 people)

Top co-used drugs for these people *:

  • Enbrel (379 people)
  • Folic Acid (364 people)
  • Humira (325 people)
  • Prednisone (184 people)
  • Omeprazole (77 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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