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Review: could Methotrexate cause Itching?

Summary: Itching could be caused by Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Folic acid, and have Rheumatoid arthritis.

We study 129,658 people who have side effects while taking Methotrexate from FDA and social media. Among them, 1,782 have Itching. Find out below who they are, when they have Itching and more.

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Methotrexate

Methotrexate (latest outcomes from 130,985 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Itching

Itching (latest reports from 537,396 patients) has been reported by people with high blood cholesterol, high blood pressure, rheumatoid arthritis, pain, multiple sclerosis.

On Apr, 7, 2014: 129,615 people reported to have side effects when taking Methotrexate. Among them, 1,730 people (1.33%) have Itching. They amount to 0.32% of all the 535,881 people who have Itching on eHealthMe.

Trend of Itching in Methotrexate reports

Time on Methotrexate when people have Itching * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Itching46.83%15.08%7.94%8.73%13.49%7.14%0.79%

Gender of people who have Itching when taking Methotrexate * :

FemaleMale
Itching79.57%20.43%

Age of people who have Itching when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Itching0.00%1.38%4.55%3.59%8.90%16.76%27.72%37.10%

Severity of Itching when taking Methotrexate ** :

leastmoderateseveremost severe
Itching22.22%22.22%55.56%0.00%

How people recovered from Itching ** :

while on the drugafter off the drugnot yet
Itching0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis (988 people, 57.11%)
  2. Hypertension (110 people, 6.36%)
  3. Pain (97 people, 5.61%)
  4. Psoriasis (84 people, 4.86%)
  5. Psoriatic arthropathy (76 people, 4.39%)

Top co-used drugs for these people * :

  1. Folic acid (631 people, 36.47%)
  2. Humira (529 people, 30.58%)
  3. Enbrel (428 people, 24.74%)
  4. Prednisone (335 people, 19.36%)
  5. Remicade (282 people, 16.30%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methotrexate, Itching

You can also:

On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (4 months ago):

  • There are red circles that seem to keep getting bigger on my arms, leg, stomach, backend,shoulder,and my neck! They are not going away and getting bigger. The doctors have given me different diagnosises and the most recent is that I have ringworm, but because methotrexate weakens the immune system(it is an immune suppressent) that the ringworm is spreading quickly and getting bigger!

    Reply

  • From this study (7 months ago):

  • itching began 2 weeks ago after adding sulfasalazine approx. 4 months ago

    Reply

  • From this study (7 months ago):

  • I am having most of the symptoms of Hypothyroid, weight gain, very dry skin & hair, easily stressed, palpitations yet my doctor tells me my bloods are normal. No one seems to know why I am feeling so bad all the time.

    Reply

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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- Methotrexate side effects

 

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