Review: could Methotrexate cause Itching?


Summary

Itching is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Enbrel, and have Rheumatoid arthritis . We study 191,460 people who have side effects while taking Methotrexate from FDA and social media. Among them, 2,743 have Itching. Find out below who they are, when they have Itching and more.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

Itching

Itching has been reported by people with breathing difficulty, fever, rashes, drug ineffective, diarrhea (latest reports from 145,536 Itching patients).

On Sep, 21, 2016

191,460 people reported to have side effects when taking Methotrexate.
Among them, 2,743 people (1.43%) have Itching


Number of reports submitted per year:

Could Methotrexate cause Itching?

Time on Methotrexate when people have Itching *:

  • < 1 month: 40.4 %
  • 1 - 6 months: 15.89 %
  • 6 - 12 months: 8.61 %
  • 1 - 2 years: 11.26 %
  • 2 - 5 years: 13.91 %
  • 5 - 10 years: 7.95 %
  • 10+ years: 1.99 %

Gender of people who have Itching when taking Methotrexate *:

  • female: 80 %
  • male: 20 %

Age of people who have Itching when taking Methotrexate *:

  • 0-1: 0.05 %
  • 2-9: 1.42 %
  • 10-19: 3.83 %
  • 20-29: 3.69 %
  • 30-39: 7.95 %
  • 40-49: 16.84 %
  • 50-59: 29.33 %
  • 60+: 36.9 %

Severity if Itching when taking Methotrexate **:

  • least: 11.11 %
  • moderate: 33.33 %
  • severe: 44.44 %
  • most severe: 11.11 %

How people recovered from Itching **:

  • while on drug: 12.5 %
  • after off the drug: 25.0 %
  • not yet: 62.5 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (1,507 people, 54.94%)
  • Psoriatic Arthropathy (198 people, 7.22%)
  • Psoriasis (191 people, 6.96%)
  • Hypertension (189 people, 6.89%)
  • Pain (173 people, 6.31%)

Top co-used drugs for these people *:

  • Enbrel (752 people, 27.42%)
  • Humira (749 people, 27.31%)
  • Folic Acid (748 people, 27.27%)
  • Prednisone (388 people, 14.15%)
  • Remicade (297 people, 10.83%)

Top other side effects for these people *:

  • Rash (472 people, 17.21%)
  • Erythema (464 people, 16.92%)
  • Arthralgia (343 people, 12.50%)
  • Pain (331 people, 12.07%)
  • Nausea (277 people, 10.10%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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