Review: could Methotrexate cause Leukoencephalopathy?
Summary: Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old, have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukemia (all).
We study 129,897 people who have side effects while taking Methotrexate from FDA and social media. Among them, 326 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.
You are not alone: join a mobile support group for people who take Methotrexate and have Leukoencephalopathy >>>
Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)
Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with high blood pressure, rheumatoid arthritis, pain, non-hodgkin's lymphoma, gastrooesophageal reflux disease. (latest reports from 1,721 Leukoencephalopathy patients)
On Mar, 5, 2015: 129,897 people reported to have side effects when taking Methotrexate. Among them, 326 people (0.25%) have Leukoencephalopathy.
Time on Methotrexate when people have Leukoencephalopathy * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
Gender of people who have Leukoencephalopathy when taking Methotrexate * :
Age of people who have Leukoencephalopathy when taking Methotrexate * :
Severity of Leukoencephalopathy when taking Methotrexate ** :
How people recovered from Leukoencephalopathy ** :
Top conditions involved for these people * :
- Acute lymphocytic leukaemia (106 people, 32.52%)
- Rheumatoid arthritis (35 people, 10.74%)
- Lymphoma (26 people, 7.98%)
- Central nervous system lymphoma (21 people, 6.44%)
- Prophylaxis (21 people, 6.44%)
Top co-used drugs for these people * :
- Cytarabine (159 people, 48.77%)
- Vincristine (139 people, 42.64%)
- Cyclophosphamide (98 people, 30.06%)
- Etoposide (83 people, 25.46%)
- Mercaptopurine (62 people, 19.02%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Do you have Leukoencephalopathy while taking Methotrexate?
You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Leukoencephalopathy
- support group for people who take Methotrexate
- support group for people who have Leukoencephalopathy
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Drugs in real world that are associated with:
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Can you answer these questions (Ask a question):
- Does humira cause excessive sweating?
Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
- Would the tinnitus abate with if i discontinue methotrexate?
I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
- Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
- What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.
- Is it safe to take zocalo if you are taking humora and methotrexate
Is it safe to take all three of these together? I need to know if there is any adverse side effects of taking these drugs at the same time?
More questions for: Methotrexate, Leukoencephalopathy
You may be interested at these reviews (Write a review):
- Muscle weakness from methotrexate
I'm 61 and have taken methotrexate for 25 yrs. I've always done well with my blood results etc. Lately I've been having problems pushing a grocery cart. My arm muscles are so weak!
- Having leg cramps after 2 years on enbrel
Started having leg cramps after using Enbrel for almsot 2 years. They start the day I give the injection and have lasted 1-3 days waking me several time in the middle of the night.
- Humira: my experience
I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.
I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(
I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.
I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.
My MD is going to get me onto another injectable that I take monthly. I forget its name.
- Psoratic arthritis and trigeminal neuralgia
hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
- Spiriva caused me to swell up like a hippo.
My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
More reviews for: Methotrexate, Leukoencephalopathy
Comments from related studies:
From this study (2 weeks ago):
I had the flu for two weeks it has been gone two weeks but I stayed fatigued with dry cough. I had my infusion of Simponi Aria 10 days ago. My Methotrexate injection is due tomorrow.
From this study (2 weeks ago):
I CONTINUE TO HAVE STARING SEIZURES,WITH HEAT,ANXIETY,PAIN,STRESS,FATIGUE,MUSCLE WEAKNESS,RESTLESS LEGS AND ARMS, TIA STROKES, NAUSEA, ETC...
From this study (4 weeks ago):
The herald patch started on my lower back and after a few weeks, the rash showed up on my shoulders mostly with some on my upper back. I've been using Head & Shoulders as a body wash and moisturizing but after a few weeks, it's still there.
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