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Review: could Methotrexate cause Leukoencephalopathy?

We study 129,773 people who have side effects while taking Methotrexate from FDA and social media. Among them, 326 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.

Stay connected: join a mobile support group for people who take Methotrexate and have Leukoencephalopathy >>>

Methotrexate

Methotrexate (latest outcomes from 131,102 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

Leukoencephalopathy

Leukoencephalopathy (disease of the white matter in the brain) (latest reports from 8,883 patients) has been reported by people with high blood pressure, rheumatoid arthritis, pain, non-hodgkin's lymphoma, gastrooesophageal reflux disease.

On Aug, 16, 2014: 129,757 people reported to have side effects when taking Methotrexate. Among them, 326 people (0.25%) have Leukoencephalopathy. They amount to 3.67% of all the 8,881 people who have Leukoencephalopathy on eHealthMe.

Trend of Leukoencephalopathy in Methotrexate reports

Time on Methotrexate when people have Leukoencephalopathy * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Leukoencephalopathy60.61%22.73%9.09%3.03%1.52%0.00%3.03%

Gender of people who have Leukoencephalopathy when taking Methotrexate * :

FemaleMale
Leukoencephalopathy64.76%35.24%

Age of people who have Leukoencephalopathy when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Leukoencephalopathy0.00%22.91%32.51%2.17%4.95%6.19%13.93%17.34%

Severity of Leukoencephalopathy when taking Methotrexate ** :

n/a

How people recovered from Leukoencephalopathy ** :

n/a

Top conditions involved for these people * :

  1. Acute lymphocytic leukaemia (106 people, 32.52%)
  2. Rheumatoid arthritis (35 people, 10.74%)
  3. Lymphoma (26 people, 7.98%)
  4. Central nervous system lymphoma (21 people, 6.44%)
  5. Prophylaxis (21 people, 6.44%)

Top co-used drugs for these people * :

  1. Cytarabine (159 people, 48.77%)
  2. Vincristine (139 people, 42.64%)
  3. Cyclophosphamide (98 people, 30.06%)
  4. Etoposide (83 people, 25.46%)
  5. Mercaptopurine (62 people, 19.02%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Methotrexate and have Leukoencephalopathy
- group for people who take Methotrexate
- group for people who have Leukoencephalopathy

Comments from related studies:

  • From this study (3 days ago):

  • I have developed a rash on my upper arms, elbows, back and groin areas

    Reply

    Dennis Walter on Aug, 2, 2014:

    That sound like a Fixed drug eruption

    Reply

  • From this study (1 week ago):

  • I have been taking methotrexate 10 mg (one injection a week) since 2002. I was then under Metoject (Methotrexate) 10 mg and then 7.5 mg until February 2013 when I had mouth sores. I was told I had mouth cancer in April 2014 and has been operated mid May at the Pitie Salpetriere hospital in Paris.

    Reply

  • From this study (1 week ago):

  • I have exhausted all drug options for overactive bladder due to "resistance." Including Botox injections that had moderate results but only lasted almost two months. Also, every injection was painfully felt although I was prepped with a pain minimizing treatment. I am searching for help if any of my medication are causing the resistance.

    Reply

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On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Methotrexate used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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