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Review: could Methotrexate cause Leukoencephalopathy?

Summary: Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old, have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukemia (all).

We study 129,908 people who have side effects while taking Methotrexate from FDA and social media. Among them, 326 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.

You are not alone: join a support group for people who take Methotrexate and have Leukoencephalopathy >>>



Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,259 Methotrexate users)


Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with high blood pressure, rheumatoid arthritis, pain, non-hodgkin's lymphoma, gastrooesophageal reflux disease. (latest reports from 1,721 Leukoencephalopathy patients)

On Mar, 5, 2015: 129,897 people reported to have side effects when taking Methotrexate. Among them, 326 people (0.25%) have Leukoencephalopathy.

Trend of Leukoencephalopathy in Methotrexate reports

Time on Methotrexate when people have Leukoencephalopathy * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Leukoencephalopathy when taking Methotrexate * :


Age of people who have Leukoencephalopathy when taking Methotrexate * :


Severity of Leukoencephalopathy when taking Methotrexate ** :


How people recovered from Leukoencephalopathy ** :


Top conditions involved for these people * :

  1. Acute lymphocytic leukaemia (106 people, 32.52%)
  2. Rheumatoid arthritis (35 people, 10.74%)
  3. Lymphoma (26 people, 7.98%)
  4. Central nervous system lymphoma (21 people, 6.44%)
  5. Prophylaxis (21 people, 6.44%)

Top co-used drugs for these people * :

  1. Cytarabine (159 people, 48.77%)
  2. Vincristine (139 people, 42.64%)
  3. Cyclophosphamide (98 people, 30.06%)
  4. Etoposide (83 people, 25.46%)
  5. Mercaptopurine (62 people, 19.02%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Leukoencephalopathy while taking Methotrexate?




You are not alone! Join a mobile support group on :
- support group for people who take Methotrexate and have Leukoencephalopathy
- support group for people who take Methotrexate
- support group for people who have Leukoencephalopathy

Drugs in real world that are associated with:

Could your condition cause:

Recent related drug studies (Check your drugs):

Recent Methotrexate related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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