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Review: could Methotrexate cause Leukoencephalopathy?

Summary: Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old, have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukemia (all).

We study 129,882 people who have side effects while taking Methotrexate from FDA and social media. Among them, 326 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Leukoencephalopathy >>>

 

 

 

 

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,224 Methotrexate users)

Leukoencephalopathy

Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with high blood pressure, rheumatoid arthritis, pain, non-hodgkin's lymphoma, gastrooesophageal reflux disease. (latest reports from 1,721 Leukoencephalopathy patients)

On Jan, 1, 2015: 129,858 people reported to have side effects when taking Methotrexate. Among them, 326 people (0.25%) have Leukoencephalopathy.

Trend of Leukoencephalopathy in Methotrexate reports

Time on Methotrexate when people have Leukoencephalopathy * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Leukoencephalopathy60.61%22.73%9.09%3.03%1.52%0.00%3.03%

Gender of people who have Leukoencephalopathy when taking Methotrexate * :

FemaleMale
Leukoencephalopathy64.76%35.24%

Age of people who have Leukoencephalopathy when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Leukoencephalopathy0.00%22.91%32.51%2.17%4.95%6.19%13.93%17.34%

Severity of Leukoencephalopathy when taking Methotrexate ** :

n/a

How people recovered from Leukoencephalopathy ** :

n/a

Top conditions involved for these people * :

  1. Acute lymphocytic leukaemia (106 people, 32.52%)
  2. Rheumatoid arthritis (35 people, 10.74%)
  3. Lymphoma (26 people, 7.98%)
  4. Central nervous system lymphoma (21 people, 6.44%)
  5. Prophylaxis (21 people, 6.44%)

Top co-used drugs for these people * :

  1. Cytarabine (159 people, 48.77%)
  2. Vincristine (139 people, 42.64%)
  3. Cyclophosphamide (98 people, 30.06%)
  4. Etoposide (83 people, 25.46%)
  5. Mercaptopurine (62 people, 19.02%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Leukoencephalopathy while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Leukoencephalopathy
- support group for people who take Methotrexate
- support group for people who have Leukoencephalopathy

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More questions for: Methotrexate, Leukoencephalopathy

You may be interested at these reviews (Write a review):

  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Personalized review of arava (1 response)
    Have had RA for 10 years and was on Methotrexate those 10 years. Had nose bleeds which got progressively worse over the years and began to effect my quality of living. Doctor said it could NOT be the drug, but according to eHealth Me, it could. At urging of an ENT, I stopped taking Methotrexate and the nose bleeds have now almost completely stopped. My doctor put me on Arava 3 days ago and I am on eHealth to study the effects of it.

More reviews for: Methotrexate, Leukoencephalopathy

Comments from related studies:

  • From this study (3 days ago):

  • My chest begin after walking or cycling at a heart rate of 90-95 bpm for 5 minutes
    and increase in intensity for 10 minutes and a heart rate 100-105. The chest pains
    subside gradually and disappear after 5 more minutes of continued walking or cycling.

    I had the same condition before taking Folic acid and Methotrexate.

    Reply

  • From this study (5 days ago):

  • recurring vertigo that lasts from an hour to a couple of days per episode

    Reply

  • From this study (2 weeks ago):

  • Since taking my last methotrexate injection I have had gastritis/pancreatitis. Previously had ercp twice.

    Reply

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