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Review: could Methotrexate cause Leukoencephalopathy?





Summary: Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old, have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukaemia.

We study 129,858 people who have side effects while taking Methotrexate from FDA and social media. Among them, 326 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.

You are not alone: join a mobile support group for people who take Methotrexate and have Leukoencephalopathy >>>

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 131,201 users)

Leukoencephalopathy

Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with high blood pressure, rheumatoid arthritis, pain, non-hodgkin's lymphoma, gastrooesophageal reflux disease.(latest reports from Leukoencephalopathy 1,721 patients)

On Dec, 2, 2014: 129,841 people reported to have side effects when taking Methotrexate. Among them, 326 people (0.25%) have Leukoencephalopathy.

Trend of Leukoencephalopathy in Methotrexate reports

Time on Methotrexate when people have Leukoencephalopathy * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Leukoencephalopathy60.61%22.73%9.09%3.03%1.52%0.00%3.03%

Gender of people who have Leukoencephalopathy when taking Methotrexate * :

FemaleMale
Leukoencephalopathy64.76%35.24%

Age of people who have Leukoencephalopathy when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Leukoencephalopathy0.00%22.91%32.51%2.17%4.95%6.19%13.93%17.34%

Severity of Leukoencephalopathy when taking Methotrexate ** :

n/a

How people recovered from Leukoencephalopathy ** :

n/a

Top conditions involved for these people * :

  1. Acute lymphocytic leukaemia (106 people, 32.52%)
  2. Rheumatoid arthritis (35 people, 10.74%)
  3. Lymphoma (26 people, 7.98%)
  4. Central nervous system lymphoma (21 people, 6.44%)
  5. Prophylaxis (21 people, 6.44%)

Top co-used drugs for these people * :

  1. Cytarabine (159 people, 48.77%)
  2. Vincristine (139 people, 42.64%)
  3. Cyclophosphamide (98 people, 30.06%)
  4. Etoposide (83 people, 25.46%)
  5. Mercaptopurine (62 people, 19.02%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Leukoencephalopathy while taking Methotrexate?

You are not alone! Join a mobile support group:
- support group for people who take Methotrexate and have Leukoencephalopathy
- support group for people who take Methotrexate
- support group for people who have Leukoencephalopathy

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