Could Methotrexate cause Leukoencephalopathy - from FDA reports
Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old , have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukemia (all) . We study 197,034 people who have side effects while taking Methotrexate from FDA. Among them, 432 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.
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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,494 users)
Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with acute lymphocytic leukemia (all), rheumatoid arthritis, high blood pressure, multiple myeloma, pain (latest reports from 2,445 Leukoencephalopathy patients).
On Nov, 21, 2016
197,034 people reported to have side effects when taking Methotrexate.
Among them, 432 people (0.22%) have Leukoencephalopathy
Number of reports submitted per year:
Time on Methotrexate when people have Leukoencephalopathy *:
- < 1 month: 63.64 %
- 1 - 6 months: 20.78 %
- 6 - 12 months: 7.79 %
- 1 - 2 years: 3.9 %
- 2 - 5 years: 1.3 %
- 5 - 10 years: 0.0 %
- 10+ years: 2.6 %
Gender of people who have Leukoencephalopathy when taking Methotrexate *:
- female: 60.63 %
- male: 39.37 %
Age of people who have Leukoencephalopathy when taking Methotrexate *:
- 0-1: 0.29 %
- 2-9: 20.11 %
- 10-19: 36.78 %
- 20-29: 2.01 %
- 30-39: 6.32 %
- 40-49: 5.75 %
- 50-59: 12.93 %
- 60+: 15.8 %
Top co-used drugs for these people *:
- Cytarabine (138 people, 31.94%)
- Vincristine (129 people, 29.86%)
- Cyclophosphamide (79 people, 18.29%)
- Etoposide (71 people, 16.44%)
- Prednisone (46 people, 10.65%)
Forecasts by ePatient.care (We will alert you to new symptoms or undetected conditions when you take Methotrexate, learn more )
Potential co-existing conditions
- Acute Lymphocytic Leukemia (all) (120 people, 27.78%)
- Non-Hodgkin's Lymphoma (24 people, 5.56%)
Potential co-existing symptoms
- Speech Impairment (adult) (55 people, 12.73%)
- Weakness (44 people, 10.19%)
- Neurotoxicity (41 people, 9.49%)
- Convulsion (36 people, 8.33%)
- Headache (33 people, 7.64%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Do you have Leukoencephalopathy when taking Methotrexate?
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Can you answer these questions?
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