Could Methotrexate cause Leukoencephalopathy - from FDA reports


Summary

Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old , have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukemia (all) . We study 197,034 people who have side effects while taking Methotrexate from FDA. Among them, 432 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA since 1977. Our tools are simple to use, anonymous and free. Start now >>>

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,494 users)

Leukoencephalopathy

Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with acute lymphocytic leukemia (all), rheumatoid arthritis, high blood pressure, multiple myeloma, pain (latest reports from 2,445 Leukoencephalopathy patients).

On Nov, 21, 2016

197,034 people reported to have side effects when taking Methotrexate.
Among them, 432 people (0.22%) have Leukoencephalopathy


Number of reports submitted per year:

Could Methotrexate cause Leukoencephalopathy?

Time on Methotrexate when people have Leukoencephalopathy *:

  • < 1 month: 63.64 %
  • 1 - 6 months: 20.78 %
  • 6 - 12 months: 7.79 %
  • 1 - 2 years: 3.9 %
  • 2 - 5 years: 1.3 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 2.6 %

Gender of people who have Leukoencephalopathy when taking Methotrexate *:

  • female: 60.63 %
  • male: 39.37 %

Age of people who have Leukoencephalopathy when taking Methotrexate *:

  • 0-1: 0.29 %
  • 2-9: 20.11 %
  • 10-19: 36.78 %
  • 20-29: 2.01 %
  • 30-39: 6.32 %
  • 40-49: 5.75 %
  • 50-59: 12.93 %
  • 60+: 15.8 %

Top co-used drugs for these people *:

  • Cytarabine (138 people, 31.94%)
  • Vincristine (129 people, 29.86%)
  • Cyclophosphamide (79 people, 18.29%)
  • Etoposide (71 people, 16.44%)
  • Prednisone (46 people, 10.65%)

Forecasts by ePatient.care (We will alert you to new symptoms or undetected conditions when you take Methotrexate, learn more )

Potential co-existing conditions

  • Acute Lymphocytic Leukemia (all) (120 people, 27.78%)
  • Non-Hodgkin's Lymphoma (24 people, 5.56%)

Potential co-existing symptoms

  • Speech Impairment (adult) (55 people, 12.73%)
  • Weakness (44 people, 10.19%)
  • Neurotoxicity (41 people, 9.49%)
  • Convulsion (36 people, 8.33%)
  • Headache (33 people, 7.64%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Leukoencephalopathy when taking Methotrexate?

Browse all side effects of Methotrexate

a b c d e f g h i j k l m n o p q r s t u v w x y z

Drugs that are associated with Leukoencephalopathy

Leukoencephalopathy

Could your condition cause Leukoencephalopathy

Leukoencephalopathy

Related studies

Can you answer these questions?

More questions for: Methotrexate, Leukoencephalopathy

You may be interested in these reviews

More reviews for: Methotrexate, Leukoencephalopathy