Could Methotrexate cause Leukoencephalopathy - from FDA reports
Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old , have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukemia (all) . We study 209,150 people who have side effects while taking Methotrexate from FDA. Among them, 466 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.
What to expect?
You are not alone!
Personalized health information
On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA since 1977. Our tools are simple to use, anonymous and free. Start now >>>
Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,527 users)
Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with acute lymphocytic leukemia (all), rheumatoid arthritis, high blood pressure, multiple myeloma, pain (latest reports from 2,445 Leukoencephalopathy patients).
On Jan, 07, 2017
209,150 people reported to have side effects when taking Methotrexate.
Among them, 466 people (0.22%) have Leukoencephalopathy
Number of reports submitted per year:
Time on Methotrexate when people have Leukoencephalopathy *:
- < 1 month: 60.64 %
- 1 - 6 months: 26.6 %
- 6 - 12 months: 6.38 %
- 1 - 2 years: 3.19 %
- 2 - 5 years: 1.06 %
- 5 - 10 years: 0.0 %
- 10+ years: 2.13 %
Gender of people who have Leukoencephalopathy when taking Methotrexate *:
- female: 61.41 %
- male: 38.59 %
Age of people who have Leukoencephalopathy when taking Methotrexate *:
- 0-1: 0.53 %
- 2-9: 20.63 %
- 10-19: 35.98 %
- 20-29: 2.65 %
- 30-39: 6.08 %
- 40-49: 5.29 %
- 50-59: 12.43 %
- 60+: 16.4 %
Top conditions involved for these people *:
- Acute Lymphocytic Leukemia (all) (132 people, 28.33%)
- Rheumatoid Arthritis (37 people, 7.94%)
- Non-Hodgkin's Lymphoma (26 people, 5.58%)
- Central Nervous System Lymphoma (18 people, 3.86%)
- Preventive Health Care (17 people, 3.65%)
Top co-used drugs for these people *:
- Cytarabine (146 people, 31.33%)
- Cyclophosphamide (84 people, 18.03%)
- Etoposide (73 people, 15.67%)
- Prednisone (48 people, 10.30%)
- Mercaptopurine (44 people, 9.44%)
Top other side effects for these people *:
- Speech Impairment (adult) (59 people, 12.66%)
- Weakness (46 people, 9.87%)
- Neurotoxicity (43 people, 9.23%)
- Headache (36 people, 7.73%)
- Convulsion (36 people, 7.73%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Do you have Leukoencephalopathy when taking Methotrexate?
Browse all side effects of Methotrexatea b c d e f g h i j k l m n o p q r s t u v w x y z
Drugs that are associated with LeukoencephalopathyLeukoencephalopathy
Could your condition cause LeukoencephalopathyLeukoencephalopathy
Can you answer these questions?
I started a low dose (10 mg) of methotrexate for rheumatoid arthritis last week and noticed this week, after taking my second does, that my face is breaking out. Does anyone have any similar experiences? I also take 5 mg of folic acid daily. Thanks for any help you can offer up.
Not sure what where to go with this. I have fibromyalgia and relapsing polchondritus also a disability from va.. I have my flares mostly under control. As well as what to do when they become apparent. After many years on pharmaceuticals I went a different direction. With medical marijauna. ...
Hi there, My names Adele I am 41 and have RA. I had my Gall Bladder removed in March of this year due to stones and constant infections. 2 years ago I stopped taking MTX subcutaneous and unfortunately my RA has progressed to a point I have (today) re-started these. I have headache, nausea and ...
Several years ago in 2013 I was"diagnosed" with RA. I went through every medication including, humira, embral, to now IV fusions of remicade which has been almost a year. I am not feeling any better and body aches and joint pains getting worse. I started researching my symptoms and lyme kept ...
This is for my father. Shortly after starting methotrexate injections and cortisone for Rheumatoid arthritis my father started having language difficulties and now has dementia. He was diagnosed with Pick's disease. Could it be caused by these drugs? He is still taking them.
You may be interested in these reviews
Hello group! I have been suffering blood in the semen on and off for about 2 years! After about 3 months I started having blood also in the urine! The only time it stopped was when I had a high dose of antibiotics and the methotrexate and sulphazalazine had been stopped for about 3 ...
My RA is mild. The methotrexate caused my cholesterol to rise. The Lipitor caused my blood sugar to rise. The rheumatologist denied that the Methotrexate did this but I found research by peer reviewed journals that reported this finding.
Hi..I was diagnosed recently with breast cancer and one of my chemos is Methotrexate. I also have MM. I find the methotrexate is really helping my body aches.I want to see what everyone is saying about MM and methotrexate.