Methotrexate and Leukoencephalopathy - from FDA reports


Summary

Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old , have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukemia (all) . We study 209,150 people who have side effects while taking Methotrexate from FDA. Among them, 466 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.

What to expect?

If you take Methotrexate and have Leukoencephalopathy, find out what symptoms you could have in 1 year or longer.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,557 users)

Leukoencephalopathy

Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with acute lymphocytic leukemia (all), rheumatoid arthritis, high blood pressure, multiple myeloma, pain (latest reports from 2,445 Leukoencephalopathy patients).

On Feb, 12, 2017

209,150 people reported to have side effects when taking Methotrexate.
Among them, 466 people (0.22%) have Leukoencephalopathy


Number of reports submitted per year:

Could Methotrexate cause Leukoencephalopathy?

Time on Methotrexate when people have Leukoencephalopathy *:

  • < 1 month: 60.64 %
  • 1 - 6 months: 26.6 %
  • 6 - 12 months: 6.38 %
  • 1 - 2 years: 3.19 %
  • 2 - 5 years: 1.06 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 2.13 %

Gender of people who have Leukoencephalopathy when taking Methotrexate *:

  • female: 61.41 %
  • male: 38.59 %

Age of people who have Leukoencephalopathy when taking Methotrexate *:

  • 0-1: 0.53 %
  • 2-9: 20.63 %
  • 10-19: 35.98 %
  • 20-29: 2.65 %
  • 30-39: 6.08 %
  • 40-49: 5.29 %
  • 50-59: 12.43 %
  • 60+: 16.4 %

Top conditions involved for these people *:

  • Acute Lymphocytic Leukemia (all) (132 people, 28.33%)
  • Rheumatoid Arthritis (37 people, 7.94%)
  • Non-Hodgkin's Lymphoma (26 people, 5.58%)
  • Central Nervous System Lymphoma (18 people, 3.86%)
  • Preventive Health Care (17 people, 3.65%)

Top co-used drugs for these people *:

  • Cytarabine (146 people, 31.33%)
  • Cyclophosphamide (84 people, 18.03%)
  • Etoposide (73 people, 15.67%)
  • Prednisone (48 people, 10.30%)
  • Mercaptopurine (44 people, 9.44%)

Top other side effects for these people *:

  • Speech Impairment (adult) (59 people, 12.66%)
  • Weakness (46 people, 9.87%)
  • Neurotoxicity (43 people, 9.23%)
  • Headache (36 people, 7.73%)
  • Convulsion (36 people, 7.73%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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