Review: could Methotrexate cause Leukoencephalopathy?


Summary

Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old , have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukaemia . We study 150,779 people who have side effects while taking Methotrexate from FDA and social media. Among them, 343 have Leukoencephalopathy. Find out below who they are, when they have Leukoencephalopathy and more.

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Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

Leukoencephalopathy

Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with rhonchi (latest reports from 2,399 Leukoencephalopathy patients).

On Aug, 29, 2016

150,779 people reported to have side effects when taking Methotrexate.
Among them, 343 people (0.23%) have Leukoencephalopathy


Number of reports submitted per year:

Could Methotrexate cause Leukoencephalopathy?

Time on Methotrexate when people have Leukoencephalopathy *:

  • < 1 month: 55.17 %
  • 1 - 6 months: 24.14 %
  • 6 - 12 months: 10.34 %
  • 1 - 2 years: 5.17 %
  • 2 - 5 years: 1.72 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 3.45 %

Gender of people who have Leukoencephalopathy when taking Methotrexate *:

  • female: 63.52 %
  • male: 36.48 %

Age of people who have Leukoencephalopathy when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 21.4 %
  • 10-19: 32.98 %
  • 20-29: 1.4 %
  • 30-39: 5.26 %
  • 40-49: 7.02 %
  • 50-59: 14.39 %
  • 60+: 17.54 %

Top conditions involved for these people *:

  • Acute Lymphocytic Leukaemia (91 people, 26.53%)
  • Rheumatoid Arthritis (32 people, 9.33%)
  • Prophylaxis (16 people, 4.66%)
  • Central Nervous System Lymphoma (15 people, 4.37%)
  • Lymphoma (14 people, 4.08%)

Top co-used drugs for these people *:

  • Cytarabine (125 people, 36.44%)
  • Vincristine (112 people, 32.65%)
  • Cyclophosphamide (77 people, 22.45%)
  • Etoposide (71 people, 20.70%)
  • Prednisone (45 people, 13.12%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

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