Review: could Methotrexate cause Lyme Disease?


Lyme disease is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 10+ years, also take medication Enbrel, and have Rheumatoid arthritis . We study 150,775 people who have side effects while taking Methotrexate from FDA and social media. Among them, 34 have Lyme disease. Find out below who they are, when they have Lyme disease and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 152,717 users)

Lyme Disease

Lyme disease (a bacterial infection that is spread to humans by infected ticks) has been reported by people with breathing difficulty, pain, weakness, paraesthesia, joint pain (latest reports from 1,777 Lyme disease patients).

On Aug, 20, 2016

150,775 people reported to have side effects when taking Methotrexate.
Among them, 34 people (0.02%) have Lyme Disease

Number of reports submitted per year:

Could Methotrexate cause Lyme disease?

Time on Methotrexate when people have Lyme Disease *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 100 %

Gender of people who have Lyme Disease when taking Methotrexate *:

  • female: 60.61 %
  • male: 39.39 %

Age of people who have Lyme Disease when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 22.22 %
  • 20-29: 3.7 %
  • 30-39: 7.41 %
  • 40-49: 25.93 %
  • 50-59: 14.81 %
  • 60+: 25.93 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (21 people)
  • Crohn's Disease (5 people)
  • Hypertension (3 people)
  • Hypersensitivity (2 people)
  • Blood Cholesterol Increased (2 people)

Top co-used drugs for these people *:

  • Enbrel (12 people)
  • Folic Acid (11 people)
  • Humira (8 people)
  • Prednisone (5 people)
  • Thalidomide (4 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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