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Review: could Methotrexate cause Lyme disease?

Summary: Lyme disease could be caused by Methotrexate, especially for people who are male, 10-19 old, also take Humira, and have Rheumatoid arthritis.

We study 129,658 people who have side effects while taking Methotrexate from FDA and social media. Among them, 27 have Lyme disease. Find out below who they are, when they have Lyme disease and more.

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On Apr, 8, 2014: 129,615 people reported to have side effects when taking Methotrexate. Among them, 27 people (0.02%) have Lyme Disease. They amount to 0.64% of all the 4,223 people who have Lyme Disease on eHealthMe.

Trend of Lyme disease in Methotrexate reports

Time on Methotrexate when people have Lyme disease * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Lyme disease0.00%0.00%0.00%0.00%0.00%0.00%100.00%

Gender of people who have Lyme disease when taking Methotrexate * :

FemaleMale
Lyme disease35.71%64.29%

Age of people who have Lyme disease when taking Methotrexate * :

0-12-910-1920-2930-3940-4950-5960+
Lyme disease0.00%0.00%39.13%4.35%0.00%30.43%17.39%8.70%

Severity of Lyme disease when taking Methotrexate ** :

n/a

How people recovered from Lyme disease ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (15 people, 55.56%)
  2. Crohn's disease (5 people, 18.52%)
  3. Acute leukaemia (2 people, 7.41%)
  4. Leukaemia (2 people, 7.41%)
  5. Vitamin supplementation (2 people, 7.41%)

Top co-used drugs for these people * :

  1. Humira (7 people, 25.93%)
  2. Prednisolone (6 people, 22.22%)
  3. Enbrel (6 people, 22.22%)
  4. Folic acid (6 people, 22.22%)
  5. Enalapril maleate (4 people, 14.81%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

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Related topic: Methotrexate, Lyme disease

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On eHealthMe, Methotrexate (methotrexate sodium) is often used for rheumatoid arthritis. Find out below the conditions Methotrexate is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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Comments from related studies:

  • From this study (2 days ago):

  • I never had any symptoms of raynauds until is was put on methotrexate,and then Enbrel,and now Humira.I used a automotive laser thermometer to check my arm
    temp. which was 97 degrees,however my fingers on the same arm were between
    69-72 degrees.

    Reply

  • From this study (2 days ago):

  • Dosage for methotrexate is 15 to 17 mg. over ten year period.
    Have been taking about 800 mg. of frolic acid per day, plus whatever occurs naturally in food.
    For about a year have been dealing with urinary retention. Don't know if there is a connection.
    Will be seeing my doctor tomorrow .

    Also take generic Zantac

    Reply

  • From this study (5 days ago):

  • lower leg pain for approximately two months

    Reply

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