Methotrexate and Lymphedema - from FDA reports


Lymphedema is found among people who take Methotrexate, especially for people who are female, 50-59 old also take medication Arava, and have Rheumatoid arthritis. This review analyzes which people have Lymphedema with Methotrexate. It is created by eHealthMe based on reports of 223,372 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

What to expect?

If you take Methotrexate and have Lymphedema, find out what symptoms you could have in 1 year or longer.

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On Apr, 05, 2017

223,372 people reported to have side effects when taking Methotrexate.
Among them, 8 people (0.0%) have Lymphedema

Number of reports submitted per year:

Could Methotrexate cause Lymphedema?

Gender of people who have Lymphedema when taking Methotrexate *:

  • female: 87.5 %
  • male: 12.5 %

Age of people who have Lymphedema when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (8 people, 100.00%)

Top co-used drugs for these people *:

  • Prednisone (7 people, 87.50%)
  • Ibuprofen (7 people, 87.50%)
  • Arava (7 people, 87.50%)
  • Hydrochlorothiazide (5 people, 62.50%)
  • Chloroquine Phosphate (4 people, 50.00%)

Top other side effects for these people *:

  • Pain (7 people, 87.50%)
  • Malaise (7 people, 87.50%)
  • High Blood Pressure (7 people, 87.50%)
  • Dry Throat (7 people, 87.50%)
  • Drug Ineffective (7 people, 87.50%)

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Lymphedema when taking Methotrexate?


Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 226,847 users)


Lymphedema (a condition of localized fluid retention and tissue swelling of lymph node) has been reported by people with rheumatoid arthritis, deep venous thrombosis, neoplasm malignant, birth control, pain (latest reports from 87 Lymphedema patients).

Browse all side effects of Methotrexate

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Drugs that are associated with Lymphedema


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