Review: could Methotrexate cause Lymphedema?


Lymphedema is found among people who take Methotrexate, especially for people who are female, 50-59 old also take medication Aas Infantil, and have Rheumatoid arthritis . We study 197,009 people who have side effects while taking Methotrexate from FDA and social media. Among them, 7 have Lymphedema. Find out below who they are, when they have Lymphedema and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,463 users)


Lymphedema (a condition of localized fluid retention and tissue swelling of lymph node) has been reported by people with high blood pressure, rheumatoid arthritis, deep venous thrombosis, neoplasm malignant, birth control (latest reports from 77 Lymphedema patients).

On Oct, 20, 2016

197,009 people reported to have side effects when taking Methotrexate.
Among them, 7 people (0.0%) have Lymphedema

Number of reports submitted per year:

Could Methotrexate cause Lymphedema?

Gender of people who have Lymphedema when taking Methotrexate *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Lymphedema when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (7 people, 100.00%)

Top co-used drugs for these people *:

  • Prednisone (7 people, 100.00%)
  • Ibuprofen (7 people, 100.00%)
  • Arava (7 people, 100.00%)
  • Aas Infantil (7 people, 100.00%)
  • Rituximab (6 people, 85.71%)

Top other side effects for these people *:

  • Pain (7 people, 100.00%)
  • Malaise (7 people, 100.00%)
  • Hypertension (7 people, 100.00%)
  • Dry Throat (7 people, 100.00%)
  • Drug Ineffective (7 people, 100.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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