Review: could Methotrexate cause Lymphoma?


Lymphoma is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Remicade, and have Rheumatoid arthritis . We study 150,777 people who have side effects while taking Methotrexate from FDA and social media. Among them, 582 have Lymphoma. Find out below who they are, when they have Lymphoma and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 152,717 users)


Lymphoma (cancer that begins in immune system cells) has been reported by people with breathing difficulty, death, sepsis, febrile neutropenia, diarrhea (latest reports from 10,252 Lymphoma patients).

On Aug, 23, 2016

150,777 people reported to have side effects when taking Methotrexate.
Among them, 582 people (0.39%) have Lymphoma

Number of reports submitted per year:

Could Methotrexate cause Lymphoma?

Time on Methotrexate when people have Lymphoma *:

  • < 1 month: 16.84 %
  • 1 - 6 months: 18.95 %
  • 6 - 12 months: 4.21 %
  • 1 - 2 years: 12.63 %
  • 2 - 5 years: 18.95 %
  • 5 - 10 years: 18.95 %
  • 10+ years: 9.47 %

Gender of people who have Lymphoma when taking Methotrexate *:

  • female: 69.22 %
  • male: 30.78 %

Age of people who have Lymphoma when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 1.54 %
  • 10-19: 3.08 %
  • 20-29: 2.56 %
  • 30-39: 3.33 %
  • 40-49: 8.72 %
  • 50-59: 22.05 %
  • 60+: 58.72 %

Top conditions involved for these people *:

  • Rheumatoid Arthritis (380 people)
  • Psoriatic Arthropathy (34 people)
  • Hypertension (26 people)
  • Pain (20 people)
  • Gastrooesophageal Reflux Disease (20 people)

Top co-used drugs for these people *:

  • Remicade (205 people)
  • Folic Acid (138 people)
  • Enbrel (106 people)
  • Prednisone (91 people)
  • Humira (85 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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