Who have Lymphoma with Methotrexate?


Lymphoma is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Remicade, and have Rheumatoid arthritis . We study 197,034 people who have side effects while taking Methotrexate from FDA and social media. Among them, 705 have Lymphoma. Find out below who they are, when they have Lymphoma and more.

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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,494 users)


Lymphoma (cancer that begins in immune system cells) has been reported by people with rheumatoid arthritis, lymphoma, multiple sclerosis, crohn's disease, high blood pressure (latest reports from 15,450 Lymphoma patients).

On Nov, 23, 2016

197,034 people reported to have side effects when taking Methotrexate.
Among them, 705 people (0.36%) have Lymphoma

Number of reports submitted per year:

Could Methotrexate cause Lymphoma?

Time on Methotrexate when people have Lymphoma *:

  • < 1 month: 15.52 %
  • 1 - 6 months: 18.1 %
  • 6 - 12 months: 4.31 %
  • 1 - 2 years: 11.21 %
  • 2 - 5 years: 19.83 %
  • 5 - 10 years: 23.28 %
  • 10+ years: 7.76 %

Gender of people who have Lymphoma when taking Methotrexate *:

  • female: 68.53 %
  • male: 31.47 %

Age of people who have Lymphoma when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 1.23 %
  • 10-19: 2.67 %
  • 20-29: 2.46 %
  • 30-39: 4.52 %
  • 40-49: 9.03 %
  • 50-59: 21.77 %
  • 60+: 58.32 %

Top co-used drugs for these people *:

  • Remicade (222 people, 31.49%)
  • Folic Acid (139 people, 19.72%)
  • Enbrel (128 people, 18.16%)
  • Humira (106 people, 15.04%)
  • Prednisone (93 people, 13.19%)

Forecasts by ePatient.care (We will alert you to new symptoms or undetected conditions when you take Methotrexate, learn more )

Potential co-existing conditions

  • Psoriatic Arthropathy (45 people, 6.38%)
  • High Blood Pressure (36 people, 5.11%)

Potential co-existing symptoms

  • Lymph Follicular Hypertrophy (58 people, 8.23%)
  • Fever (38 people, 5.39%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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